GRAP2 Mouse Monoclonal Antibody [Clone ID: UW40]

Specifications

Product Data
Clone Name	UW40
Applications	FC, IP, WB
Recommend Dilution	Flow cytometry: 1 μg/ml. Immunoprecipitation. Western blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	GST-fusion human GRAP2/GADS protein
Specificity	This antibody detects recognizes GRAP2/GADS, a 41 kDa cytoplasmic adaptor protein that plays a pivotal role during the early events of signal transduction in T cells.
Formulation	Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4 State: Aff - Purified State: Liquid Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	GRB2-related adaptor protein 2
Database Link	Entrez Gene 9402 Human UniProt ID O75791
Background	GRAP2/GADS (Grb2-related adaptor protein 2 / Grb2-related adaptor downstream of Shc) is a cytoplasmic adaptor protein containing N- and C-terminal SH3 domains flanking a central SH2 domain and a proline/glutamine-rich region. It is expressed predominantly in lymphoid tissue and hematopoietic cells, particularly in T cells. GRAP2/GADS plays a pivotal role during the early events of T cell signal transduction by recruiting the adaptor protein SLP-76 and its associated molecules, such as Vav, Nck, Itk, and ADAP, to the transmembrane adaptor protein LAT. GRAP2/GADS also binds several other signaling proteins, namely Gab2, HPK1 (hematopoietic progenitor kinase 1), and Cbl. Unlike similar adaptor protein Grb2, GRAP2/GADS shows higher selectivity when binding to the particular phosphorylated tyrosines of LAT adaptor.
Synonyms	GADS, GRBLG, GRB2L, Grf-40, GRBX, GRID
Reference Data
Protein Families	Druggable Genome
Protein Pathways	T cell receptor signaling pathway

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