SHC (SHC1) (C-term) (incl. pos. control) Mouse Monoclonal Antibody [Clone ID: 11F6]
CAT#: AM00140PU-N
SHC (SHC1) (C-term) (incl. pos. control) mouse monoclonal antibody, clone 11F6, Purified
Need it in bulk or conjugated?
Get a free quote
CNY 5,973.00
货期*
5周
规格
Specifications
Product Data | |
Clone Name | 11F6 |
Applications | IF, IHC, WB |
Recommend Dilution | Western Blot: 1 µg/ml for HRPO/ECL detection. Recommended buffer: Casein/Tween 20 based blocking and blot incubation buffer. Recommended positive control: Cell lysate from untreated 3T3 cells. Immunocytochemistry. Immunohistochemistry. |
Reactivity | Human, Mouse |
Host | Mouse |
Clonality | Monoclonal |
Immunogen | Synthetic peptide conjugated to hemocyanin |
Specificity | This antibody specifically recognizes the C-terminus of shc. |
Formulation | 1 ml PBS / 0.09 % Na-azide / PEG and Sucrose State: Purified State: Lyophilized purified IgG |
Reconstitution Method | Restore with 1 ml H2O (15 min, RT). |
Purification | Subsequent thiophilic adsorption and size exclusion chromatography |
Conjugation | Unconjugated |
Storage Condition | For long-term storage, freeze lyophilizate upon arrival (-20°C). Upon reconstitution, aliquote and freeze in liquid nitrogen. Avoid repeated freezing and thawing. |
Gene Name | SHC adaptor protein 1 |
Database Link | |
Background | Mammalian cells can express three alternatively spliced isoforms of the shc adaptor protein: shc/p46, shc/p52 and shc/p66. shc/p66 contains a unique N-terminal protein domain. In addition to tyrosine phosphorylation of Tyr 239/240 and/or Tyr 317, shc/p66 is phosphorylated at serine 36, e.g. in response to EGF. Serine phosphorylation of shc/p66 impairs its ability to bind to the activated EGF receptor thus inhibiting EGF receptor downstream signalling pathways. |
Synonyms | SHC-transforming protein 1, SHC-transforming protein A, SHC-transforming protein 3, SHCA |
Reference Data |
Documents
Product Manuals |
FAQs |
SDS |
Resources
抗体相关资料 |
Customer
Reviews
Loading...