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OriGene proteins in recent publications

Fully functional proteins purified from transient TrueORF cDNA clone transfections. Researchers purified GEN1 protein using anti-FLAG M2 affinity column and determined it resolved Holliday junction X0 efficiently in vitro, thus confirming GEN1 is human Holliday junction resolvase.

Identification of Holliday junction resolvases from humans and yeast, Stephen C. Y. Ip, Ulrich Rass, Miguel G. Blanco, Helen R. Flynn, J. Mark Skehel, Stephen C. West, Nature 456, 357 - 361 (20 Nov 2008), doi: 10.1038/nature07470,

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IL6 (NM_000600) Purified Human Protein

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Product Documents

Cat. No.	Description	Datasheet	Price	Availability*
TP750006-1000	Recombinant protein of human Interleukin 6(IL-6) produced in E. coli., 1 mg (Larger pack size?)		￥3500.00	3-4 周
TA50011-100	4C5, Anti-DDK monoclonal antibody (100 μL)		￥1000	现货

Also for IL6 (NM_000600)

OriGene Data

Species:	Human	Expression Host:	E. coli
Expression cDNA Clone or AA Sequence	A DNA sequence from TrueORF clone, RC202078, encoding the region (Pro29-Met212) of IL6
Tag:	Tag-free	Predicted MW:	20.9 kDa
Purity:	>95% as determined by SDS-PAGE and Coomassie blue staining
Mass Spec Validation:	This protein has been positively validated by MS/MS by Dr. Robert Moritz at The Institute of Systems Biology.
Concentration:	Resuspend the protein to the desired concentration in proper buffer.
Buffer:	Lyophilized from a sterile solution containing 20 mM phosphate buffer, pH7.4. Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Endotoxin:	<0.1 EU per 1 ?g of the protein by the LAL
BioActivity:	Determined by the dose-dependant stimulation of murine 7TD1 cells. ED50 for this effect is typically 0.009-0.014 ng/ml.
Protein Families:	Secreted Protein Druggable Genome
Protein Pathways:	Cytokine-cytokine receptor interaction Toll-like receptor signaling pathway NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway Jak-STAT signaling pathway Hematopoietic cell lineage More Pathways >>

Protein Data

Reference Data

RefSeq: NP_000591	RefSeq Size: 1125	RefSeq ORF: 639
LocusID: 3569	Cytogenetic: 7p15.3
Synonyms : BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6
Summary: This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].

*: Inventory for certain proteins may be limited due to low expression level. Delivery time may vary from web posted schedule. Contact techsupport@origene.com for specific inventory information

**: DDK-tag is the same as FLAG tag. Flag? is a registered trademark of Sigma-Aldrich

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IL6 (NM_000600) Purified Human Protein

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