Products

Proteins

Recombinant Proteins

Human

TNF ALPHA

IGF1

VEGFA

IL6

PTPRN

BDNF

EOTAXIN 3

FGF1

IL1 BETA

IL4

NRG1

ALPHA SYNUCLEIN

BMP2

BNP

HMG1

SDF1

CAMK2B

FABP4

FERRITIN HEAVY CHAIN

GABARAP

HIP2

IL3

IL8

INTERFERON ALPHA 2

PDGF AA

SONIC HEDGEHOG

SUMO 3

TGIF

TRAIL

APOLIPOPROTEIN E

BIRC5

BLNK

DESMIN

FGF2

GDNF

IL15

LIF

NEUROTROPHIN 3

PDGFA

AMPHIREGULIN

APE1

ASB13

ASS1

BETA ARRESTIN 1

BID

BMP4

CALCITONIN

CASPASE 10

CSNK1G2

CXCL14

EGF

EGR1

FIBRONECTIN

GADD45B

GLUTATHIONE TRANSFERASE ZETA 1

IL17

IL17F

IL1RA

IL2

IL7

INHIBIN BETA C CHAIN

INTERFERON GAMMA

KGF

KLF6

LEPTIN

MAX

MGMT

NCK

NEDD8

OGG1

ONCOSTATIN M

PARATHYROID HORMONE

PCNA

PDCD10

PDGF BETA

PEROXIREDOXIN 4

PEROXIREDOXIN 6

PGP9.5

PKIB

PTPN11

SENP2

SENP7

SUMO 1

SUPEROXIDE DISMUTASE 1

SYNTAXIN 6

TRYPTOPHANYL TRNA SYNTHETASE

UBE2G2

UBIQUITIN

VILIP1

VINCULIN

YY1

14-3-3 EPSILON

14-3-3 SIGMA

ABCB5

ACADM

ACID PHOSPHATASE

AIF

AKR1C2

AKR1C4

ALDH1A1

HEK293T

HEK293

E. coli

Sf9

Insect

CHO

Baculovirus

Pichia

N-His

Tag Free

C-His

N-GST and C-His

N-GST and C-HIS

N-GST

N-His-ABP (Albumin-Binding Protein)

His-tag

N-His-Trx

N-His&C-His

N-Trx&His

Tag-free

N-GST&His

N-His&SUMO

C-Avi&6His

C-HIS

N-6His

N-HIS

N-His&C-Fc

N-His&T7

N-MARI

N-T7&C-His

N-Trx

Myc-DDK

N-GST, C-His

N-His-PDCD1(Pro21-Val170)

N-AVI

N-DDK

N-FUSION

N-GFP

N-GST(CKM) and N-His(CKB)

N-His-GST

N-T7

N-TRX

N-TRXA

N-terminal His

Druggable Genome

Secreted Protein

Transcription Factors

Transmembrane

ES Cell Differentiation/IPS

Protein Kinase

Stem cell - Pluripotency

Protease

Adult stem cells

Embryonic stem cells

Phosphatase

Induced pluripotent stem cells

Ion Channels: Other

Cancer stem cells

Stem cell relevant signaling - TGFb/BMP signaling pathway

Stem cell relevant signaling - JAK/STAT signaling pathway

Stem cell relevant signaling - Wnt Signaling pathway

Stem cell relevant signaling - DSL/Notch pathway

10 mM Tris-HCl

GPCR

Nuclear Hormone Receptor

the solution can be further dialyzed against PBS (phosphate buffered saline

2 mM dithiothreitol

ELISA.
Western Blot.

e.g. Dulbecco's PBS).

Ion Channels: Potassium

both dissolved in 9.5 M urea buffer (see above). Protofilaments and filament complexes are obtained by dialyzing the resulting polypeptide solution stepwise to a concentration of 4 M urea and then to low salt condition (50 mM NaCl

Protein standard in 1D and 2D SDS gelelectrophoresis.
Immunoassays.
Immunization.
Protocol: Reconstitution to filaments is performed by mixing equimolar amounts of keratins of type I and type II at concentrations of approx. 0.5 mg/ml

P450

pH 7.4). For immunization purposes

Ion Channels: Transient receptor potential

Protein standard in 1D and 2D SDS gelelectrophoresis.
Immunoassays.
Immunization.
Protocol: Reconstitution to filaments is performed by mixing equimolar amounts of keratins of type I and type II at concentrations of approx. 0.5 mg/ml

pH 7.4).
For immunization purposes

pH 7.4).
For immunization purposes

Ion Channels: Cys-loop Receptors

Protein standard in 1D and 2D SDS gelelectrophoresis.
Immunoblotting.
Receptor-binding studies.

Western Blot.

0.1% (w/v) insulin

10mM Tris-HCl

1mM DTT

2 mM dithiothreitol

2mM EDTA.
2. Add 4ug of recombinant thioredoxin into reaction cocktail and mix immediately.
3. Incubate at 25°C for 20 minutes.
4. Record the increase in A650nm for 15 minutes

2mM dithiothreitol

63mM sodium phosphate

Protein standard in 1D and 2D SDS gelelectrophoresis.
Immunoassays.
Immunization.
Protocol: Reconstitution to filaments: After vimentin is dissolved in 9.5M Urea buffer (see above)

Can be used as standard in a Sandwich ELISA.

Ion Channels: Sodium

Protein standard in 1D and 2D SDS gelelectrophoresis.
Immunoassays.
Immunization.
Protocol: Reconstitution to filaments: after desmin is dissolved in 9.5 M urea buffer (see above)

Protocol: Activity Assay
1. Prepare a 1 ml reaction cocktail into a suitable container: The final concentrations are 5mM Tris

both dissolved in 9.5 M urea buffer (see above).
Protofilaments and filament complexes are obtained by dialyzing the resulting polypeptide solution stepwise to a concentration of 4 M urea and then to low salt condition (50 mM NaCl

e.g. Dulbeccos PBS).

e.g.Dulbecco's PBS).

protofilaments and filament complexes are obtained by dialyzing the resulting polypeptide solution stepwise to a concentration of 4M Urea and then to low salt condition (50mM NaCl

protofilaments and filament complexes are obtained by dialyzing the resulting polypeptide solution stepwise to a concentration of 4M urea and then to low salt condition (50 mM NaCl

the solution can be further dialyzed against PBS (Phosphate Buffered Saline

ELISA.
Western blotting.

Positive control for Western blot analysis.
Standard for ELISA.

Adermann K. Role of the prosequence of guanylin. Protein Sci. 1999 Sep; 8(9): 1850-9.
4. Lauber T

Cohen MB. Proguanylin secretion and the role of negative-feedback inhibition in a villous epithelial cell line. Am J Physiol Gastrointest Liver Physiol. 2002 Sep; 283(3): G695-702.
3. Schulz A

ELISA

ELISA.
Western blotting.

Forssmann WG

Hawkins JA

Hidaka Y

Ion Channels: ATP Receptors

Marx UC

Marx UC. Native and recombinant proguanylin feature identical biophysical properties and are monomeric in solution. Biochemistry. 2002 Dec 10; 41(49): 14602-12.
2. Rudolph JA

Marx UC. Solution structure of human proguanylin: the role of a hormone prosequence. J Biol Chem. 2003 Jun 27; 278(26): 24118-24. Epub 2003 Apr 21.

Neudecker P

Nourse A

Rosch P

Schulz A

Shimonishi Y

Western Blot.
Protocol: 1. Lauber T

Western Blotting.

Cytokine-cytokine receptor interaction

Pathways in cancer

Metabolic pathways

MAPK signaling pathway

Jak-STAT signaling pathway

Chemokine signaling pathway

Hematopoietic cell lineage

Focal adhesion

Regulation of actin cytoskeleton

Toll-like receptor signaling pathway

Apoptosis

Melanoma

T cell receptor signaling pathway

NOD-like receptor signaling pathway

Natural killer cell mediated cytotoxicity

Prostate cancer

Alzheimer's disease

Neurotrophin signaling pathway

TGF-beta signaling pathway

ErbB signaling pathway

Fc epsilon RI signaling pathway

Type I diabetes mellitus

Glioma

Hypertrophic cardiomyopathy (HCM)

Cell cycle

Graft-versus-host disease

Amyotrophic lateral sclerosis (ALS)

p53 signaling pathway

Oocyte meiosis

RIG-I-like receptor signaling pathway

Wnt signaling pathway

Renal cell carcinoma

Cytosolic DNA-sensing pathway

Dilated cardiomyopathy

Colorectal cancer

Pancreatic cancer

Prion diseases

Adipocytokine signaling pathway

Small cell lung cancer

Chronic myeloid leukemia

Gap junction

Allograft rejection

B cell receptor signaling pathway

Melanogenesis

Acute myeloid leukemia

Asthma

Bladder cancer

Huntington's disease

Hedgehog signaling pathway

Insulin signaling pathway

Parkinson's disease

Ubiquitin mediated proteolysis

Base excision repair

Progesterone-mediated oocyte maturation

Axon guidance

Endocytosis

Systemic lupus erythematosus

Type II diabetes mellitus

Calcium signaling pathway

mTOR signaling pathway

VEGF signaling pathway

Autoimmune thyroid disease

Basal cell carcinoma

Epithelial cell signaling in Helicobacter pylori infection

GnRH signaling pathway

Leukocyte transendothelial migration

Long-term potentiation

Adherens junction

Endometrial cancer

Nitrogen metabolism

Purine metabolism

Vascular smooth muscle contraction

Arginine and proline metabolism

Neuroactive ligand-receptor interaction

Pyrimidine metabolism

Regulation of autophagy

ECM-receptor interaction

Long-term depression

PPAR signaling pathway

Complement and coagulation cascades

Glycolysis / Gluconeogenesis

Non-small cell lung cancer

Primary immunodeficiency

Antigen processing and presentation

Metabolism of xenobiotics by cytochrome P450

Porphyrin and chlorophyll metabolism

Glutathione metabolism

Tryptophan metabolism

Tyrosine metabolism

Cell adhesion molecules (CAMs)

Fc gamma R-mediated phagocytosis

Phenylalanine metabolism

ABC transporters

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

Fructose and mannose metabolism

Glycine

serine and threonine metabolism

Amino sugar and nucleotide sugar metabolism

Olfactory transduction

Pyruvate metabolism

Cardiac muscle contraction

Cysteine and methionine metabolism

Mismatch repair

Nucleotide excision repair

SNARE interactions in vesicular transport

Thyroid cancer

Tight junction

Drug metabolism - cytochrome P450

Retinol metabolism

Ribosome

Dorso-ventral axis formation

Homologous recombination

Pathogenic Escherichia coli infection

Propanoate metabolism

Viral myocarditis

Butanoate metabolism

Citrate cycle (TCA cycle)

Drug metabolism - other enzymes

Fatty acid metabolism

Lysine degradation

Phosphatidylinositol signaling system

Androgen and estrogen metabolism

Galactose metabolism

Methane metabolism

Notch signaling pathway

Renin-angiotensin system

Synthesis and degradation of ketone bodies

Ubiquinone and other terpenoid-quinone biosynthesis

Aminoacyl-tRNA biosynthesis

Glyoxylate and dicarboxylate metabolism

Inositol phosphate metabolism

Lysosome

Oxidative phosphorylation

Proteasome

Valine

leucine and isoleucine degradation

Alanine

Arachidonic acid metabolism

Basal transcription factors

DNA replication

Riboflavin metabolism

Terpenoid backbone biosynthesis

Vibrio cholerae infection

aspartate and glutamate metabolism

C21-Steroid hormone metabolism

Glycerophospholipid metabolism

Histidine metabolism

Nicotinate and nicotinamide metabolism

Pentose and glucuronate interconversions

Pentose phosphate pathway

Primary bile acid biosynthesis

RNA degradation

Circadian rhythm - mammal

D-Arginine and D-ornithine metabolism

Ether lipid metabolism

Folate biosynthesis

Maturity onset diabetes of the young

One carbon pool by folate

Selenoamino acid metabolism

Taste transduction

beta-Alanine metabolism

Linoleic acid metabolism

N-Glycan biosynthesis

Non-homologous end-joining

Pantothenate and CoA biosynthesis

Phenylalanine

Sphingolipid metabolism

Starch and sucrose metabolism

alpha-Linolenic acid metabolism

tyrosine and tryptophan biosynthesis

Ascorbate and aldarate metabolism

Fatty acid elongation in mitochondria

Glycosphingolipid biosynthesis - lacto and neolacto series

Heparan sulfate biosynthesis

Keratan sulfate biosynthesis

Other glycan degradation

Protein export

RNA polymerase

Spliceosome

Steroid biosynthesis

leucine and isoleucine biosynthesis

1

2

Yes

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