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Species
- Human (44260)
- Mouse (7899)
- Escherichia coli (164)
- SARS-CoV-2 (89)
- Rat (85)
- Cynomolgus (80)
- Rhesus (22)
- Bovine (18)
- Staphylococcus aureus (13)
- Rabbit (11)
- Blomia tropicalis (10)
- Chicken (7)
- viral (7)
- 2019-nCoV (6)
- Dermatophagoides pteronyssinus (6)
- Orf Virus (5)
- Saccharomyces cerevisiae (5)
- Streptococcus Pyogenes (5)
- Protozoan (4)
- Schistosoma (4)
- Streptococcus (4)
- Hepatitis B Virus (3)
- Mycobacteria (3)
- A. victoria (2)
- Adenovirus 6 (2)
- C. elegans (2)
- Cavia porcellus (2)
- Dermatophagoides farinae (2)
- Drosophila (2)
- HIV (2)
- High Gc Gram+ (2)
- Human, Rat (2)
- Monkey (2)
- Photinus Pyr. (2)
- Porcine (2)
- Streptococcus sp. (2)
- Yeast (2)
- Alternaria alternata (1)
- Apicomplexan (1)
- B.subtilis (1)
- Bacterial (1)
- Betula pendula (1)
- Borrelia burgdorferi (1)
- Campylobacter jejuni (1)
- Canine (1)
- Carassiusauratus (1)
- Chlorocebus aethiops (1)
- D. aromatica (1)
- Drosophila melanogaster (1)
- E.coli (1)
- Enterobacteria phage T4 (1)
- Escherichia phage T7 (1)
- Feline (1)
- Hamster (1)
- Hirudo medicinalis (1)
- Human herpesvirus (1)
- Human papillomavirus (1)
- Humon (1)
- Humulus japonicus (1)
- Klebsiella pneumoniae (1)
- Lachnospiraceae bacterium ND2006 (1)
- Lepidoglyphus destructor (1)
- Leptotrichia wadei (1)
- Macaca fascicularis (1)
- Marmoset (1)
- Mucor hiemalis (1)
- Mus musculus (1)
- Pig (1)
- Proteobacteria (1)
- S. hygroscopicus (1)
- SIV (1)
- Serratia marcescens (1)
- Sheep (1)
- Spirochetes (1)
- Staphylococcus aureus subsp. (1)
- Streptomyces avidinii (1)
- Streptomyces plicatus (1)
- T. fusca (1)
- TEV (1)
- Tobacco etch virus (1)
- Vaccinia virus (1)
- Vacciniavirus (1)
- Vibrio cholerae (1)
Target Symbol
- VEGFA (58)
- PD-L1 (40)
- MESOTHELIN (34)
- PD1 (34)
- EPCAM (33)
- ALPHA 1 ANTITRYPSIN (32)
- NCALD (32)
- IL6 (30)
- FGF1 (29)
- TACD2 (29)
- HER2 (28)
- IL2 (27)
- SNCA (27)
- IRF5 (25)
- NDRG2 (25)
- S PROTEIN (25)
- FGF2 (24)
- CD22 (23)
- FGFR1 (22)
- IGF1 (22)
- IL4 (22)
- ISOCITRATE DEHYDROGENASE (22)
- PQBP1 (22)
- UBE2D3 (22)
- ALKALINE PHOSPHATASE (21)
- ALPHA SYNUCLEIN (21)
- CPNE1 (21)
- CSF2 (21)
- HMGA1 (21)
- MAX (21)
- RIBONUCLEASE INHIBITOR (21)
- TNF ALPHA (21)
- TPM1 (21)
- CD19 (20)
- CD7 (20)
- CTLA4 (20)
- EGFR (20)
- FSTL1 (20)
- ICAM2 (20)
- IL22 (20)
- IL33 (20)
- M-CSF (20)
- MIF (20)
- MORTALITY FACTOR 4 LIKE 2 (20)
- BCMA (19)
- CD38 (19)
- MTH1 (19)
- PRKAR1B (19)
- UBE2I (19)
- AURORA A (18)
- CD30 (18)
- CD36 (18)
- CD3E (18)
- CD47 (18)
- EGF (18)
- FGL1 (18)
- IL12B (18)
- MYOSIN (18)
- S100A8 (18)
- ADIPOQ (17)
- CD137 (17)
- CD70 (17)
- CNTF (17)
- FHL1 (17)
- GALE (17)
- IL8 (17)
- LIF (17)
- PCBP2 (17)
- PCSK9 (17)
- PGF (17)
- RNA5-8SN2 (17)
- S100 CALCIUM BINDING PROTEIN A13 (17)
- SOD2 (17)
- SULT1A1 (17)
- TNF (17)
- ALDOLASE (16)
- ARSA (16)
- B3GALT5 (16)
- BETA 2 MICROGLOBULIN (16)
- CATHEPSIN B (16)
- CD83 (16)
- CUTA (16)
- DYNLL1 (16)
- FHL2 (16)
- FKBP2 (16)
- GLUTAMINE SYNTHETASE (16)
- GM CSF (16)
- HMG1 (16)
- IL1B (16)
- MBNL1 (16)
- MICA (16)
- MYELIN BASIC PROTEIN (16)
- NDUF3 (16)
- TROPOMYOSIN 3 (16)
- 14-3-3 ZETA (15)
- ACRV1 (15)
- AKT1 (15)
- ASPARTATE BETA HYDROXYLASE (15)
- BDNF (15)
- CD16 (15)
Expression Hosts
Tags
- C-Myc/DDK (27882)
- C-MYC/DDK (6899)
- His-tag (5792)
- C-His (3786)
- N-His (2908)
- Tag Free (840)
- C-Fc (452)
- N-GST and C-His (441)
- C-6His (298)
- C-Human Fc (269)
- C-DDK (201)
- C-6×His (175)
- N-GST and C-HIS (150)
- N-GST (112)
- C-DDK/His (104)
- C-His-Avi (68)
- Myc-DDK (67)
- C-Fc&His (60)
- C-FLAG (58)
- N-6His (55)
- C-Mouse Fc (54)
- N-His-ABP (Albumin-Binding Protein) (52)
- N-Human Fc (51)
- C-mFc (50)
- C-HIS (49)
- N-His-SUMO (49)
- C-Fc-Avi (48)
- His-Tag (44)
- N-His&C-His (42)
- C-6His-Avi (37)
- C-8His (33)
- C-Mouse Fc and 6×His (32)
- T7-tag (30)
- C-hFc (24)
- N-T7&C-His (24)
- N-Trx&His (24)
- C-Avi-6His (18)
- N-His-Trx (18)
- C-Human Fc and 6×His (16)
- C-10His (14)
- N-Fc (13)
- N-GST, C-His (13)
- hIgG-His-Tag (12)
- N-HIS (10)
- N-His&SUMO (10)
- hIgG-His-tag (10)
- C- 6×His (8)
- N-6×His (8)
- N-GST&His (8)
- Tag-free (8)
- C-6xHis (7)
- C-Avi&6His (7)
- hIgG-Tag (6)
- C-AVI&His (5)
- C-Fc&AVI (5)
- N-8His (5)
- N-Avi (5)
- N-His PDCD1(Pro21-Val170) (5)
- N-His/DDK (5)
- N-Mouse Fc and C-6×His (5)
- C-6×His tag and C-Human Fc (4)
- C-TEV-8His (4)
- C-mouse Fc (4)
- His-Cam-tag (4)
- His-MBP-tag (4)
- N-6His-Avi (4)
- N-His&C-Fc (4)
- N-His&T7 (4)
- N-His-GST (4)
- N-MARI (4)
- N-Trx (4)
- C-Fc/His (3)
- C-Flag (3)
- C-hFc&His (3)
- His-tagged, myc-tagged (3)
- N-DDK (3)
- N-His&Flag (3)
- N-mFc (3)
- C-3×Flag Tag (2)
- C-6xHis/AVI (2)
- C-7×His (2)
- C-Avi&His (2)
- C-DDK-His (2)
- C-FC (2)
- C-Fc-Flag&C-Fc-6His (2)
- C-HUMAN (2)
- CaM-tag (2)
- Calmodulin-tag (2)
- Fc chimera (2)
- Myc-His-tag (2)
- N-6His-Flag (2)
- N-6xHis/AVI (2)
- N-8His&N-FLAG (2)
- N-FC (2)
- N-FLAG (2)
- N-Fc-FLAG (2)
- N-GFP (2)
- N-His-PDCD1(Pro21-Val170) (2)
- N-Mouse Fc (2)
- N-TrxA (2)
- N-terminal His (2)
- N-terminal His-PDCD1(Pro21-Val170) tag (2)
- TrxA (2)
- C-AVI (1)
- C-AVI-PLUS (1)
- C-Avi (1)
- C-Avi-10His (1)
- C-Avi-His (1)
- C-DDK/10xHis (1)
- C-DDK/6xHis (1)
- C-FC-6HIS&C-FC-Flag (1)
- C-FC/6xHis (1)
- C-FLAG-6His (1)
- C-FLAG-Fc (1)
- C-Fc Human (1)
- C-Fc Mouse (1)
- C-Flag,C-6His (1)
- C-GST (1)
- C-HIS/C (1)
- C-HIS/DDK (1)
- C-His&AVI (1)
- C-His&Flag (1)
- C-His&HA&AVI (1)
- C-His/AVIplus (1)
- C-His/DDK (1)
- C-Human Fc, Avi (1)
- C-Human Fc-Avi (1)
- C-MIgG2a (1)
- C-hIgG1 Fc (1)
- C-hIgG2 Fc (1)
- C-hIgG4 Fc (1)
- C-hIgG4P Fc (1)
- C-mFC (1)
- C-mFc&His (1)
- C-mIgG2AFc (1)
- C-mIgG2a Fc (1)
- C-mIgG2aFc (1)
- C-terminal DDK (1)
- DDK-tag (1)
- His tag (1)
- N-10*His (1)
- N-10His (1)
- N-10His-Flag (1)
- N-6His&Avi (1)
- N-6His, C-6His (1)
- N-6His-FLAG (1)
- N-6xHis (1)
- N-8His-Flag (1)
- N-AVI (1)
- N-AVI&His (1)
- N-Avi&6His (1)
- N-BBP&His (1)
- N-DDK/His (1)
- N-FUSION (1)
- N-Flag&C-His (1)
- N-Flag&His (1)
- N-GST(CKM) and N-His(CKB) (1)
- N-HIS and C-AVIPLUS (1)
- N-His&MBP (1)
- N-PROTEIN (1)
- N-T7 (1)
- N-TRX (1)
- N-TRXA (1)
- N-Trx-His (1)
- N-hFc (1)
- N-terminal His-tag (1)
- N-terminal murine Fc Tag (1)
- No (1)
- Tag free (1)
Conjugates
Mutants
Brands
QC Levels
Families
- Druggable Genome (19889)
- Transmembrane (7937)
- Secreted Protein (4762)
- Transcription Factors (4109)
- Protein Kinase (1695)
- ES Cell Differentiation/IPS (1557)
- Protease (1306)
- Stem cell - Pluripotency (1218)
- Phosphatase (546)
- Adult stem cells (348)
- Ion Channels: Other (262)
- Embryonic stem cells (261)
- Cancer stem cells (179)
- Nuclear Hormone Receptor (171)
- Induced pluripotent stem cells (153)
- P450 (134)
- GPCR (122)
- Stem cell relevant signaling - JAK/STAT signaling pathway (119)
- Stem cell relevant signaling - TGFb/BMP signaling pathway (83)
- Stem cell relevant signaling - Wnt Signaling pathway (71)
- Stem cell relevant signaling - DSL/Notch pathway (64)
- Ion Channels: Potassium (40)
- Ion Channels: Cys-loop Receptors (19)
- Ion Channels: Glutamate Receptors (19)
- Ion Channels: ATP Receptors (13)
- Ion Channels: Transient receptor potential (13)
- Ion Channels: Sodium (10)
- ELISA (3)
- Ion Channels: Cyclic nucleotide gated (3)
- 000) and Immunohistochemistry (1/200-1/1 (1)
-
000) as well as other phosphatase-Biotin/biotin based enzymatic assays.
Assay by Immunoelectrophoresis resulted in a single precipitin arc against anti-Alkaline Phosphatase (calf intestine) and anti-Biotin. (1) - 000-1/32 (1)
- 1/500-1/2 (1)
- 10 mM Tris-HCl (1)
- 2 mM dithiothreitol (1)
- 500) (1)
-
Protein standard in 1D and 2D SDS gelelectrophoresis.
Immunoassays.
Immunization.
Protocol: Reconstitution to filaments is performed by mixing equimolar amounts of keratins of type I and type II at concentrations of approx. 0.5 mg/ml (1) - ELISA (1/8 (1)
- FACS (1)
- Suitable for Immunoblotting (Western or Dot blot (1)
- The DYKDDDDK peptide (Flag) is used as a fusion tag for immunoaffinity chromatography. (1)
- both dissolved in 9.5 M urea buffer (see above). Protofilaments and filament complexes are obtained by dialyzing the resulting polypeptide solution stepwise to a concentration of 4 M urea and then to low salt condition (50 mM NaCl (1)
- e.g. Dulbecco's PBS). (1)
-
pH 7.4).
For immunization purposes (1) - the solution can be further dialyzed against PBS (phosphate buffered saline (1)
Pathways
- Metabolic pathways (3768)
- Cytokine-cytokine receptor interaction (1645)
- Pathways in cancer (1585)
- MAPK signaling pathway (1275)
- Focal adhesion (892)
- Regulation of actin cytoskeleton (881)
- Chemokine signaling pathway (806)
- Jak-STAT signaling pathway (776)
- Endocytosis (727)
- Natural killer cell mediated cytotoxicity (656)
- Neurotrophin signaling pathway (621)
- T cell receptor signaling pathway (621)
- Hematopoietic cell lineage (605)
- Purine metabolism (586)
- Toll-like receptor signaling pathway (579)
- Alzheimer's disease (567)
- Ubiquitin mediated proteolysis (543)
- Cell adhesion molecules (CAMs) (541)
- Insulin signaling pathway (541)
- Axon guidance (487)
- Huntington's disease (487)
- Cell cycle (478)
- Wnt signaling pathway (477)
- Leukocyte transendothelial migration (467)
- ErbB signaling pathway (465)
- Prostate cancer (462)
- Apoptosis (455)
- Pancreatic cancer (443)
- Melanoma (428)
- Pyrimidine metabolism (426)
- Tight junction (424)
- Progesterone-mediated oocyte maturation (416)
- Fc epsilon RI signaling pathway (409)
- Oocyte meiosis (403)
- Spliceosome (403)
- Renal cell carcinoma (400)
- Colorectal cancer (392)
- Adherens junction (391)
- GnRH signaling pathway (386)
- TGF-beta signaling pathway (378)
- NOD-like receptor signaling pathway (373)
- Lysosome (371)
- Antigen processing and presentation (370)
- Parkinson's disease (368)
- Calcium signaling pathway (365)
- Fc gamma R-mediated phagocytosis (361)
- RIG-I-like receptor signaling pathway (361)
- Hypertrophic cardiomyopathy (HCM) (356)
- B cell receptor signaling pathway (354)
- Chronic myeloid leukemia (351)
- Glioma (348)
- VEGF signaling pathway (346)
- Glycolysis / Gluconeogenesis (344)
- Dilated cardiomyopathy (338)
- Epithelial cell signaling in Helicobacter pylori infection (324)
- Systemic lupus erythematosus (323)
- p53 signaling pathway (318)
- Adipocytokine signaling pathway (317)
- Bladder cancer (313)
- Small cell lung cancer (313)
- PPAR signaling pathway (311)
- Gap junction (307)
- Complement and coagulation cascades (296)
- Melanogenesis (288)
- Cytosolic DNA-sensing pathway (287)
- Acute myeloid leukemia (282)
- Vascular smooth muscle contraction (278)
- Arginine and proline metabolism (274)
- Type I diabetes mellitus (269)
- Endometrial cancer (268)
- Long-term potentiation (268)
- Non-small cell lung cancer (268)
- Oxidative phosphorylation (265)
- Amyotrophic lateral sclerosis (ALS) (261)
- Pathogenic Escherichia coli infection (257)
- Autoimmune thyroid disease (256)
- mTOR signaling pathway (256)
- Viral myocarditis (248)
- Glutathione metabolism (240)
- Long-term depression (240)
- Metabolism of xenobiotics by cytochrome P450 (238)
- Phosphatidylinositol signaling system (237)
- Amino sugar and nucleotide sugar metabolism (236)
- Drug metabolism - cytochrome P450 (227)
- Allograft rejection (222)
- Graft-versus-host disease (218)
- ECM-receptor interaction (212)
- Fructose and mannose metabolism (202)
- Cardiac muscle contraction (201)
- Type II diabetes mellitus (198)
- Tyrosine metabolism (196)
- Ribosome (195)
- Valine (195)
- Proteasome (194)
- Arrhythmogenic right ventricular cardiomyopathy (ARVC) (192)
- Inositol phosphate metabolism (191)
- Prion diseases (191)
- Neuroactive ligand-receptor interaction (187)
- Drug metabolism - other enzymes (184)
- leucine and isoleucine degradation (182)
- Thyroid cancer (181)
- Glycerophospholipid metabolism (179)
- RNA degradation (176)
- Cysteine and methionine metabolism (173)
- Pyruvate metabolism (173)
- Tryptophan metabolism (168)
- Alanine (166)
- Hedgehog signaling pathway (166)
- Regulation of autophagy (166)
- aspartate and glutamate metabolism (166)
- Retinol metabolism (165)
- Fatty acid metabolism (164)
- Starch and sucrose metabolism (162)
- Vibrio cholerae infection (159)
- Pentose phosphate pathway (158)
- Base excision repair (156)
- Primary immunodeficiency (156)
- Arachidonic acid metabolism (151)
- Nitrogen metabolism (149)
- Asthma (146)
- Porphyrin and chlorophyll metabolism (144)
- Androgen and estrogen metabolism (139)
- Glycerolipid metabolism (138)
- Nucleotide excision repair (136)
- SNARE interactions in vesicular transport (133)
- Galactose metabolism (131)
- Butanoate metabolism (130)
- Citrate cycle (TCA cycle) (128)
- Propanoate metabolism (121)
- Basal cell carcinoma (117)
- DNA replication (115)
- Glycine (115)
- serine and threonine metabolism (115)
- Aminoacyl-tRNA biosynthesis (114)
- Lysine degradation (113)
- Histidine metabolism (112)
- beta-Alanine metabolism (107)
- Nicotinate and nicotinamide metabolism (106)
- Sphingolipid metabolism (105)
- Phenylalanine metabolism (101)
- Olfactory transduction (100)
- Notch signaling pathway (96)
- Dorso-ventral axis formation (94)
- RNA polymerase (94)
- Selenoamino acid metabolism (87)
- Ether lipid metabolism (86)
- Maturity onset diabetes of the young (86)
- Sulfur metabolism (86)
- Glyoxylate and dicarboxylate metabolism (82)
- Homologous recombination (80)
- Linoleic acid metabolism (77)
- Mismatch repair (77)
- Riboflavin metabolism (77)
- Pentose and glucuronate interconversions (76)
- Terpenoid backbone biosynthesis (75)
- Pantothenate and CoA biosynthesis (72)
- Basal transcription factors (71)
- Renin-angiotensin system (71)
- Other glycan degradation (70)
- Glycosaminoglycan degradation (69)
- N-Glycan biosynthesis (64)
- One carbon pool by folate (62)
- Ascorbate and aldarate metabolism (61)
- Glycosphingolipid biosynthesis - lacto and neolacto series (57)
- Folate biosynthesis (53)
- Primary bile acid biosynthesis (50)
- Taste transduction (50)
- C21-Steroid hormone metabolism (48)
- Limonene and pinene degradation (47)
- alpha-Linolenic acid metabolism (45)
- Glycosphingolipid biosynthesis - globo series (43)
- Synthesis and degradation of ketone bodies (43)
- O-Glycan biosynthesis (40)
- Thiamine metabolism (40)
- Biosynthesis of unsaturated fatty acids (37)
- Methane metabolism (37)
- Non-homologous end-joining (35)
- Heparan sulfate biosynthesis (33)
- Keratan sulfate biosynthesis (32)
- Circadian rhythm - mammal (31)
- Steroid biosynthesis (31)
- ABC transporters (29)
- Fatty acid elongation in mitochondria (28)
- Taurine and hypotaurine metabolism (28)
- Glycosphingolipid biosynthesis - ganglio series (26)
- Ubiquinone and other terpenoid-quinone biosynthesis (25)
- Chondroitin sulfate biosynthesis (24)
- Phenylalanine (24)
- leucine and isoleucine biosynthesis (24)
- tyrosine and tryptophan biosynthesis (24)
- Glycosylphosphatidylinositol(GPI)-anchor biosynthesis (23)
- Protein export (22)
- Caffeine metabolism (20)
- Vitamin B6 metabolism (20)
- Fatty acid biosynthesis (15)
- Cyanoamino acid metabolism (14)
- Lysine biosynthesis (14)
- D-Glutamine and D-glutamate metabolism (13)
- D-Arginine and D-ornithine metabolism (8)
- Biotin metabolism (6)
- O-Mannosyl glycan biosynthesis (4)
- Lipoic acid metabolism (1)