Over-expression Lysates

Proteins

Over-expression Lysates

Human

CDC25C

CDC7

PCNA

MCM4

P53

TP53

CHEK1

CHK1

CDK1

CDK7

CHEK2

CHK2

GADD45A

HDAC1

HDAC2

MCM2

MCM3

MCM5

MCM6

ORC1

ORC2

WEE1

BUB1B

BUBR1

C-MYC

CCNA2

CCNB2

CCND1

CCNE1

CDC45

CDC45L

CYCLIN A2

CYCLIN B2

CYCLIN D1

CYCLIN E1

MYC

ORC6

ORC6L

HEK293T

C-Myc/DDK

Druggable Genome

Transcription Factors

Stem cell - Pluripotency

Protein Kinase

Phosphatase

Stem cell relevant signaling - JAK/STAT signaling pathway

Embryonic stem cells

Stem cell relevant signaling - TGFb/BMP signaling pathway

Cancer stem cells

ES Cell Differentiation/IPS

Secreted Protein

Stem cell relevant signaling - DSL/Notch pathway

Transmembrane

Stem cell relevant signaling - Wnt Signaling pathway

Adult stem cells

Induced pluripotent stem cells

Cell cycle

Pathways in cancer

Metabolic pathways

DNA replication

Spliceosome

Base excision repair

Nucleotide excision repair

Mismatch repair

p53 signaling pathway

MAPK signaling pathway

Colorectal cancer

Homologous recombination

RNA degradation

Small cell lung cancer

Purine metabolism

Pyrimidine metabolism

Oocyte meiosis

Pancreatic cancer

Amyotrophic lateral sclerosis (ALS)

Prostate cancer

Focal adhesion

Apoptosis

Chronic myeloid leukemia

Huntington's disease

Wnt signaling pathway

Neurotrophin signaling pathway

Regulation of actin cytoskeleton

Endocytosis

Endometrial cancer

T cell receptor signaling pathway

Cytosolic DNA-sensing pathway

Jak-STAT signaling pathway

Non-small cell lung cancer

Progesterone-mediated oocyte maturation

Chemokine signaling pathway

Antigen processing and presentation

Bladder cancer

Proteasome

Thyroid cancer

ErbB signaling pathway

Glioma

Melanoma

Natural killer cell mediated cytotoxicity

Systemic lupus erythematosus

VEGF signaling pathway

B cell receptor signaling pathway

RNA polymerase

Acute myeloid leukemia

Basal cell carcinoma

Calcium signaling pathway

Drug metabolism - other enzymes

Glycerophospholipid metabolism

Leukocyte transendothelial migration

Notch signaling pathway

Primary immunodeficiency

Ubiquitin mediated proteolysis

Viral myocarditis

NOD-like receptor signaling pathway

Alzheimer's disease

Cytokine-cytokine receptor interaction

Fc gamma R-mediated phagocytosis

Gap junction

Insulin signaling pathway

Non-homologous end-joining

One carbon pool by folate

Parkinson's disease

Pathogenic Escherichia coli infection

SNARE interactions in vesicular transport

Adipocytokine signaling pathway

RIG-I-like receptor signaling pathway

Adherens junction

Axon guidance

Cysteine and methionine metabolism

Fructose and mannose metabolism

Glycolysis / Gluconeogenesis

Hematopoietic cell lineage

Melanogenesis

Pentose phosphate pathway

Selenoamino acid metabolism

Type I diabetes mellitus

Basal transcription factors

Cardiac muscle contraction

Dilated cardiomyopathy

ECM-receptor interaction

Epithelial cell signaling in Helicobacter pylori infection

Ether lipid metabolism

Folate biosynthesis

Glycerolipid metabolism

Glycine

Glyoxylate and dicarboxylate metabolism

Hypertrophic cardiomyopathy (HCM)

Nicotinate and nicotinamide metabolism

Prion diseases

Renal cell carcinoma

Sphingolipid metabolism

Steroid biosynthesis

TGF-beta signaling pathway

Type II diabetes mellitus

serine and threonine metabolism

1

Yes