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Species
Target Symbol
- BRCA1 (395)
- BTK (296)
- BRCA2 (277)
- GCK (255)
- TSC2 (248)
- MEN1 (242)
- MLH1 (242)
- MSH2 (216)
- RET (185)
- NOTCH3 (159)
- P53 (110)
- NF2 (103)
- MSH6 (88)
- STK11 (82)
- FGFR1 (68)
- PI 3 KINASE CATALYTIC SUBUNIT ALPHA (67)
- WT1 (64)
- FH (62)
- E4 (61)
- GNAS (60)
- L2 (60)
- CREM (50)
- L1 (50)
- EGFR (46)
- PTEN (46)
- ERCC2 (40)
- VEGFA (40)
- E3 (39)
- BDNF (37)
- FLT4 (37)
- CTNNB1 (36)
- BRAF (35)
- E1 (35)
- CACNA1C (34)
- CACNA1G (33)
- NRG1 (33)
- E6 (32)
- E7 (32)
- KCNMA1 (32)
- TERT (32)
- E2 (31)
- TPM1 (31)
- CTNND1 (28)
- PCDH15 (27)
- CBL (26)
- CDKN2A (26)
- DISC1 (26)
- TNNT3 (26)
- UTY (26)
- IKAROS (24)
- KRAS (24)
- L4 (24)
- PRKCG (24)
- HMGA1 (23)
- HRAS (23)
- PDE9A (23)
- ST3GAL3 (23)
- PLAGL1 (22)
- TCF7L2 (22)
- HYPOTHETICAL PROTEIN (21)
- L3 (21)
- RAF1 (21)
- SYTL2 (21)
- EMA (20)
- KCNJ15 (20)
- NDRG2 (20)
- NRAS (20)
- UBE2V1 (20)
- ARPP21 (19)
- FGFR2 (19)
- KCNQ2 (19)
- MU OPIOID RECEPTOR (19)
- PDLIM5 (19)
- ROR2 (19)
- RUNX1T1 (19)
- TRPM3 (19)
- ANKS1B (18)
- BIM (18)
- DYNC1I2 (18)
- DYSTROPHIN (18)
- FHL1 (18)
- IKZF3 (18)
- LDB3 (18)
- NFATC2 (18)
- PRKCBP1 (18)
- SORBS1 (18)
- TPD52L2 (18)
- BETA CATENIN (17)
- DYSTROBREVIN ALPHA (17)
- EEF1D (17)
- MIER1 (17)
- MYADM (17)
- ODF2 (17)
- PRKACB (17)
- TMEM176B (17)
- ABLIM2 (16)
- ALK (16)
- ANK1 (16)
- ATF2 (16)
- ATP2C1 (16)
Vectors
Mutants
Families
- Druggable Genome (18911)
- Transmembrane (10102)
- Transcription Factors (5296)
- Secreted Protein (2483)
- Protein Kinase (2092)
- Stem cell - Pluripotency (1107)
- Protease (895)
- ES Cell Differentiation/IPS (885)
- GPCR (596)
- Phosphatase (442)
- Ion Channels: Other (289)
- Adult stem cells (217)
- Nuclear Hormone Receptor (201)
- Ion Channels: Potassium (156)
- Embryonic stem cells (154)
- Cancer stem cells (123)
- Ion Channels: Cys-loop Receptors (94)
- Stem cell relevant signaling - JAK/STAT signaling pathway (86)
- Induced pluripotent stem cells (85)
- P450 (82)
- Ion Channels: Calcium (71)
- Ion Channels: Transient receptor potential (62)
- Stem cell relevant signaling - TGFb/BMP signaling pathway (48)
- Ion Channels: Glutamate Receptors (44)
- Stem cell relevant signaling - Wnt Signaling pathway (40)
- Stem cell relevant signaling - DSL/Notch pathway (37)
- Ion Channels: Sodium (32)
- Ion Channels: ATP Receptors (22)
- Ion Channels: Cyclic nucleotide gated (14)
Pathways
- Metabolic pathways (2551)
- Pathways in cancer (2510)
- Colorectal cancer (1098)
- MAPK signaling pathway (1092)
- Insulin signaling pathway (1036)
- Endometrial cancer (845)
- Focal adhesion (823)
- Regulation of actin cytoskeleton (819)
- Pancreatic cancer (803)
- Ubiquitin mediated proteolysis (768)
- Prostate cancer (744)
- Endocytosis (721)
- Melanoma (679)
- Neurotrophin signaling pathway (650)
- B cell receptor signaling pathway (649)
- Cytokine-cytokine receptor interaction (636)
- Chemokine signaling pathway (620)
- Fc epsilon RI signaling pathway (619)
- p53 signaling pathway (613)
- Glioma (601)
- Mismatch repair (587)
- Neuroactive ligand-receptor interaction (583)
- mTOR signaling pathway (579)
- Calcium signaling pathway (563)
- Chronic myeloid leukemia (555)
- Thyroid cancer (555)
- ErbB signaling pathway (550)
- Non-small cell lung cancer (543)
- Wnt signaling pathway (540)
- Natural killer cell mediated cytotoxicity (531)
- Tight junction (498)
- Progesterone-mediated oocyte maturation (484)
- Type II diabetes mellitus (482)
- T cell receptor signaling pathway (475)
- Huntington's disease (468)
- Renal cell carcinoma (468)
- Cell cycle (457)
- Bladder cancer (447)
- Olfactory transduction (442)
- Melanogenesis (439)
- Small cell lung cancer (438)
- Jak-STAT signaling pathway (433)
- Leukocyte transendothelial migration (433)
- GnRH signaling pathway (428)
- Vascular smooth muscle contraction (426)
- Apoptosis (416)
- Gap junction (413)
- Adherens junction (403)
- Axon guidance (400)
- Glycolysis / Gluconeogenesis (390)
- Purine metabolism (389)
- VEGF signaling pathway (389)
- Acute myeloid leukemia (386)
- Long-term depression (385)
- Primary immunodeficiency (379)
- Alzheimer's disease (375)
- Amino sugar and nucleotide sugar metabolism (352)
- Long-term potentiation (352)
- Fc gamma R-mediated phagocytosis (351)
- Starch and sucrose metabolism (348)
- Homologous recombination (337)
- Toll-like receptor signaling pathway (316)
- Dilated cardiomyopathy (305)
- Galactose metabolism (305)
- Maturity onset diabetes of the young (302)
- Oocyte meiosis (301)
- Phosphatidylinositol signaling system (292)
- Cell adhesion molecules (CAMs) (287)
- Dorso-ventral axis formation (277)
- Arrhythmogenic right ventricular cardiomyopathy (ARVC) (276)
- Basal cell carcinoma (266)
- Lysosome (261)
- Adipocytokine signaling pathway (252)
- Notch signaling pathway (247)
- Amyotrophic lateral sclerosis (ALS) (240)
- Hypertrophic cardiomyopathy (HCM) (234)
- Inositol phosphate metabolism (228)
- Hematopoietic cell lineage (220)
- Spliceosome (216)
- Pyrimidine metabolism (215)
- Parkinson's disease (213)
- Oxidative phosphorylation (210)
- Systemic lupus erythematosus (198)
- Viral myocarditis (190)
- Epithelial cell signaling in Helicobacter pylori infection (187)
- Vibrio cholerae infection (187)
- TGF-beta signaling pathway (184)
- PPAR signaling pathway (183)
- Pathogenic Escherichia coli infection (179)
- ECM-receptor interaction (176)
- Cardiac muscle contraction (166)
- Antigen processing and presentation (160)
- NOD-like receptor signaling pathway (155)
- Glycerophospholipid metabolism (153)
- Taste transduction (150)
- Complement and coagulation cascades (147)
- RIG-I-like receptor signaling pathway (147)
- Ribosome (145)
- Drug metabolism - cytochrome P450 (143)
- Metabolism of xenobiotics by cytochrome P450 (141)
- Citrate cycle (TCA cycle) (138)
- Nucleotide excision repair (129)
- RNA degradation (122)
- Arginine and proline metabolism (117)
- Cytosolic DNA-sensing pathway (116)
- Glutathione metabolism (115)
- Drug metabolism - other enzymes (113)
- Retinol metabolism (111)
- Hedgehog signaling pathway (108)
- Arachidonic acid metabolism (105)
- Valine (103)
- Prion diseases (98)
- Tyrosine metabolism (96)
- N-Glycan biosynthesis (95)
- Pyruvate metabolism (95)
- Fatty acid metabolism (93)
- Glycerolipid metabolism (90)
- Base excision repair (89)
- Lysine degradation (89)
- ABC transporters (87)
- leucine and isoleucine degradation (87)
- Autoimmune thyroid disease (86)
- Proteasome (86)
- Sphingolipid metabolism (83)
- Cysteine and methionine metabolism (79)
- Type I diabetes mellitus (79)
- Tryptophan metabolism (77)
- Porphyrin and chlorophyll metabolism (73)
- DNA replication (71)
- Fructose and mannose metabolism (69)
- Aminoacyl-tRNA biosynthesis (68)
- Glycosphingolipid biosynthesis - lacto and neolacto series (68)
- Graft-versus-host disease (68)
- Androgen and estrogen metabolism (67)
- Propanoate metabolism (67)
- Alanine (65)
- SNARE interactions in vesicular transport (65)
- aspartate and glutamate metabolism (65)
- Basal transcription factors (63)
- Allograft rejection (62)
- Ether lipid metabolism (62)
- Histidine metabolism (61)
- RNA polymerase (59)
- Glycine (58)
- Pentose phosphate pathway (58)
- Selenoamino acid metabolism (58)
- serine and threonine metabolism (58)
- Butanoate metabolism (56)
- Nitrogen metabolism (56)
- Regulation of autophagy (54)
- Phenylalanine metabolism (52)
- Glycosaminoglycan degradation (50)
- Pentose and glucuronate interconversions (49)
- Linoleic acid metabolism (48)
- Glycosylphosphatidylinositol(GPI)-anchor biosynthesis (45)
- Nicotinate and nicotinamide metabolism (45)
- O-Glycan biosynthesis (45)
- Asthma (42)
- Keratan sulfate biosynthesis (42)
- Pantothenate and CoA biosynthesis (42)
- beta-Alanine metabolism (41)
- Ascorbate and aldarate metabolism (40)
- One carbon pool by folate (40)
- Steroid biosynthesis (40)
- Biosynthesis of unsaturated fatty acids (39)
- Heparan sulfate biosynthesis (39)
- Primary bile acid biosynthesis (38)
- Riboflavin metabolism (37)
- Chondroitin sulfate biosynthesis (36)
- Other glycan degradation (33)
- Non-homologous end-joining (32)
- Sulfur metabolism (32)
- alpha-Linolenic acid metabolism (32)
- Glycosphingolipid biosynthesis - ganglio series (30)
- Glycosphingolipid biosynthesis - globo series (30)
- Glyoxylate and dicarboxylate metabolism (29)
- Renin-angiotensin system (29)
- Terpenoid backbone biosynthesis (29)
- Circadian rhythm - mammal (27)
- Cyanoamino acid metabolism (27)
- Limonene and pinene degradation (27)
- Taurine and hypotaurine metabolism (27)
- Protein export (24)
- leucine and isoleucine biosynthesis (24)
- Folate biosynthesis (20)
- Thiamine metabolism (20)
- C21-Steroid hormone metabolism (19)
- Caffeine metabolism (17)
- Fatty acid elongation in mitochondria (15)
- Synthesis and degradation of ketone bodies (14)
- Fatty acid biosynthesis (13)
- Lysine biosynthesis (12)
- Methane metabolism (12)
- Lipoic acid metabolism (11)
- O-Mannosyl glycan biosynthesis (10)
- Ubiquinone and other terpenoid-quinone biosynthesis (10)
- Phenylalanine (9)
- tyrosine and tryptophan biosynthesis (9)
- Biotin metabolism (8)
- D-Glutamine and D-glutamate metabolism (8)
- Vitamin B6 metabolism (6)
- D-Arginine and D-ornithine metabolism (1)