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cDNA Clones

Expression Plasmids

Mutant ORF Clones

Human

ERCC2

GTF2H3

RFC2

RFC5

CUL4A

DNA LIGASE I

ERCC6

HHR23A

HHR23B

POLE2

RFC1

RPA34

XPB

XPC

CDK7

CULLIN 4B

CYCLIN H

DDB1

DDB2

DNA POLYMERASE DELTA P50

DNA POLYMERASE EPSILON

ERCC1

ERCC8

POLD1

POLD3

POLD4

POLE

XPD

Myc-DDK

TurboGFP

pCMV6-Entry

No

Yes

TrueORF

TrueORF Gold, TrueORF

Druggable Genome

Transcription Factors

Stem cell - Pluripotency

Protein Kinase

Pathways in cancer

Metabolic pathways

Colorectal cancer

Insulin signaling pathway

Endometrial cancer

MAPK signaling pathway

Pancreatic cancer

Prostate cancer

Focal adhesion

Ubiquitin mediated proteolysis

Melanoma

Regulation of actin cytoskeleton

Mismatch repair

B cell receptor signaling pathway

Fc epsilon RI signaling pathway

p53 signaling pathway

mTOR signaling pathway

Glioma

Endocytosis

Thyroid cancer

Non-small cell lung cancer

Chronic myeloid leukemia

Neurotrophin signaling pathway

Type II diabetes mellitus

ErbB signaling pathway

Chemokine signaling pathway

Bladder cancer

Natural killer cell mediated cytotoxicity

Calcium signaling pathway

Renal cell carcinoma

Cytokine-cytokine receptor interaction

Tight junction

Progesterone-mediated oocyte maturation

Wnt signaling pathway

T cell receptor signaling pathway

Primary immunodeficiency

Small cell lung cancer

Neuroactive ligand-receptor interaction

Gap junction

Melanogenesis

GnRH signaling pathway

Vascular smooth muscle contraction

Homologous recombination

Long-term depression

Glycolysis / Gluconeogenesis

Acute myeloid leukemia

Adherens junction

Olfactory transduction

Starch and sucrose metabolism

Amino sugar and nucleotide sugar metabolism

Cell cycle

Apoptosis

VEGF signaling pathway

Leukocyte transendothelial migration

Huntington's disease

Long-term potentiation

Maturity onset diabetes of the young

Galactose metabolism

Jak-STAT signaling pathway

Axon guidance

Dorso-ventral axis formation

Fc gamma R-mediated phagocytosis

Phosphatidylinositol signaling system

Alzheimer's disease

Basal cell carcinoma

Notch signaling pathway

Dilated cardiomyopathy

Toll-like receptor signaling pathway

Purine metabolism

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

Amyotrophic lateral sclerosis (ALS)

Inositol phosphate metabolism

Adipocytokine signaling pathway

Cell adhesion molecules (CAMs)

Oocyte meiosis

Hypertrophic cardiomyopathy (HCM)

Vibrio cholerae infection

Lysosome

Viral myocarditis

Epithelial cell signaling in Helicobacter pylori infection

Taste transduction

ECM-receptor interaction

Pyrimidine metabolism

Citrate cycle (TCA cycle)

Pathogenic Escherichia coli infection

Hematopoietic cell lineage

Parkinson's disease

Oxidative phosphorylation

PPAR signaling pathway

Spliceosome

Cardiac muscle contraction

TGF-beta signaling pathway

Nucleotide excision repair

Glycerophospholipid metabolism

NOD-like receptor signaling pathway

ABC transporters

Drug metabolism - cytochrome P450

RIG-I-like receptor signaling pathway

Metabolism of xenobiotics by cytochrome P450

Systemic lupus erythematosus

Prion diseases

RNA degradation

Glutathione metabolism

Retinol metabolism

Complement and coagulation cascades

Drug metabolism - other enzymes

Cytosolic DNA-sensing pathway

N-Glycan biosynthesis

Arachidonic acid metabolism

Lysine degradation

Ribosome

Arginine and proline metabolism

Tyrosine metabolism

Base excision repair

Antigen processing and presentation

Hedgehog signaling pathway

Pyruvate metabolism

Fatty acid metabolism

Glycerolipid metabolism

Sphingolipid metabolism

Cysteine and methionine metabolism

Autoimmune thyroid disease

Porphyrin and chlorophyll metabolism

Type I diabetes mellitus

Valine

DNA replication

Basal transcription factors

Tryptophan metabolism

RNA polymerase

Aminoacyl-tRNA biosynthesis

Proteasome

leucine and isoleucine degradation

Androgen and estrogen metabolism

Glycosphingolipid biosynthesis - lacto and neolacto series

Pentose and glucuronate interconversions

Phenylalanine metabolism

Propanoate metabolism

Histidine metabolism

Allograft rejection

Fructose and mannose metabolism

Graft-versus-host disease

Nitrogen metabolism

Selenoamino acid metabolism

Ether lipid metabolism

Glycine

Steroid biosynthesis

serine and threonine metabolism

SNARE interactions in vesicular transport

Ascorbate and aldarate metabolism

Glycosaminoglycan degradation

Keratan sulfate biosynthesis

Pantothenate and CoA biosynthesis

Alanine

Glycosylphosphatidylinositol(GPI)-anchor biosynthesis

One carbon pool by folate

aspartate and glutamate metabolism

Pentose phosphate pathway

Nicotinate and nicotinamide metabolism

Chondroitin sulfate biosynthesis

Linoleic acid metabolism

Non-homologous end-joining

Regulation of autophagy

Riboflavin metabolism

Biosynthesis of unsaturated fatty acids

Butanoate metabolism

Cyanoamino acid metabolism

Heparan sulfate biosynthesis

Primary bile acid biosynthesis

Protein export

Circadian rhythm - mammal

Glycosphingolipid biosynthesis - ganglio series

Other glycan degradation

beta-Alanine metabolism

Asthma

Taurine and hypotaurine metabolism

Limonene and pinene degradation

O-Glycan biosynthesis

Renin-angiotensin system

alpha-Linolenic acid metabolism

Glycosphingolipid biosynthesis - globo series

Glyoxylate and dicarboxylate metabolism

Terpenoid backbone biosynthesis

Lysine biosynthesis

Thiamine metabolism

leucine and isoleucine biosynthesis

Fatty acid biosynthesis

O-Mannosyl glycan biosynthesis

Biotin metabolism

Folate biosynthesis

Sulfur metabolism

Lipoic acid metabolism

Methane metabolism

Phenylalanine

Synthesis and degradation of ketone bodies

tyrosine and tryptophan biosynthesis

Caffeine metabolism

D-Glutamine and D-glutamate metabolism

Fatty acid elongation in mitochondria

C21-Steroid hormone metabolism

Vitamin B6 metabolism

Ubiquinone and other terpenoid-quinone biosynthesis

Neomycin

1

Yes

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