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Species
Target Symbol
- BRCA1 (401)
- BTK (297)
- BRCA2 (279)
- GLUCOKINASE (252)
- MENIN (249)
- MLH1 (249)
- TUBERIN (245)
- MSH2 (218)
- RET (187)
- NOTCH3 (160)
- P53 (115)
- NF2 (110)
- MSH6 (90)
- LKB1 (83)
- CREM (78)
- FGFR1 (77)
- WILMS TUMOR PROTEIN (72)
- PI 3 KINASE CATALYTIC SUBUNIT ALPHA (69)
- CACNA1G (65)
- VEGFA (63)
- FH (62)
- E4 (61)
- CACNA1C (60)
- L2 (60)
- G PROTEIN ALPHA S (58)
- CTNND1 (53)
- PCDH15 (52)
- UTY (52)
- EGFR (50)
- L1 (50)
- BETA CATENIN (49)
- PTEN (48)
- B RAF (45)
- DISC1 (45)
- NRG1 (45)
- TPM1 (42)
- KCNMA1 (41)
- BDNF (40)
- E3 (39)
- FLT4 (39)
- ST3GAL3 (39)
- XPD (39)
- EMA (36)
- HMGA1 (36)
- IKAROS (36)
- TCF7L2 (36)
- TRPM3 (36)
- BIM (35)
- E1 (35)
- RUNX1T1 (35)
- TNNT3 (35)
- KCNQ2 (34)
- PDE9A (34)
- PDLIM5 (34)
- TELOMERASE REVERSE TRANSCRIPTASE (34)
- ARPP21 (33)
- ANKS1B (32)
- BORIS (32)
- E6 (32)
- E7 (32)
- DYSTROPHIN (31)
- E2 (31)
- FGFR2 (31)
- ODF2 (31)
- SYTL2 (31)
- ESTROGEN RELATED RECEPTOR GAMMA (30)
- KCNJ15 (30)
- MORTALITY FACTOR 4 LIKE 2 (30)
- PARD3 (30)
- IKZF3 (29)
- LDB3 (29)
- MIER1 (29)
- P16INK4A (29)
- SORBS1 (29)
- SYNTABULIN (29)
- TCF4 (29)
- ATP2C1 (28)
- DYSFERLIN (28)
- DYSTROBREVIN ALPHA (28)
- FGF1 (28)
- GLUCOCORTICOID RECEPTOR (28)
- P21 RAS (28)
- PRKACB (28)
- CBL (27)
- EDA (27)
- MBD1 (27)
- PAK3 (27)
- PDE1C (27)
- PDE4DIP (27)
- PLAGL1 (27)
- UBE2V1 (27)
- ALPHA DYSTROGLYCAN (26)
- ANK1 (26)
- CD44 (26)
- CD46 (26)
- DNMT3B (26)
- DYNC1I2 (26)
- KRAS (26)
- MU OPIOID RECEPTOR (26)
- OXR1 (26)
Mutants
Families
- Druggable Genome (25059)
- Transmembrane (14398)
- Transcription Factors (7097)
- Secreted Protein (3316)
- Protein Kinase (2559)
- Stem cell - Pluripotency (1327)
- Protease (1216)
- ES Cell Differentiation/IPS (1164)
- GPCR (848)
- Phosphatase (591)
- Ion Channels: Other (386)
- Nuclear Hormone Receptor (290)
- Adult stem cells (259)
- Ion Channels: Potassium (226)
- Embryonic stem cells (198)
- Cancer stem cells (143)
- Ion Channels: Cys-loop Receptors (141)
- Ion Channels: Calcium (139)
- P450 (109)
- Ion Channels: Transient receptor potential (105)
- Induced pluripotent stem cells (104)
- Stem cell relevant signaling - JAK/STAT signaling pathway (99)
- Ion Channels: Glutamate Receptors (71)
- Stem cell relevant signaling - DSL/Notch pathway (56)
- Stem cell relevant signaling - TGFb/BMP signaling pathway (55)
- Ion Channels: Sodium (54)
- Stem cell relevant signaling - Wnt Signaling pathway (44)
- Ion Channels: ATP Receptors (30)
- Ion Channels: Cyclic nucleotide gated (22)
Pathways
- Metabolic pathways (3283)
- Pathways in cancer (2850)
- MAPK signaling pathway (1413)
- Colorectal cancer (1182)
- Insulin signaling pathway (1153)
- Focal adhesion (1031)
- Regulation of actin cytoskeleton (1029)
- Ubiquitin mediated proteolysis (911)
- Endometrial cancer (905)
- Pancreatic cancer (885)
- Endocytosis (883)
- Neuroactive ligand-receptor interaction (856)
- Prostate cancer (851)
- Cytokine-cytokine receptor interaction (847)
- Calcium signaling pathway (804)
- Chemokine signaling pathway (766)
- Melanoma (757)
- Neurotrophin signaling pathway (753)
- Olfactory transduction (729)
- B cell receptor signaling pathway (723)
- p53 signaling pathway (705)
- Fc epsilon RI signaling pathway (672)
- Wnt signaling pathway (670)
- Natural killer cell mediated cytotoxicity (661)
- Glioma (659)
- ErbB signaling pathway (646)
- mTOR signaling pathway (644)
- Tight junction (637)
- Chronic myeloid leukemia (621)
- Progesterone-mediated oocyte maturation (617)
- Huntington's disease (611)
- Mismatch repair (611)
- Type II diabetes mellitus (592)
- Non-small cell lung cancer (588)
- Thyroid cancer (586)
- T cell receptor signaling pathway (576)
- Jak-STAT signaling pathway (572)
- Vascular smooth muscle contraction (557)
- Cell cycle (552)
- Renal cell carcinoma (551)
- Alzheimer's disease (546)
- Leukocyte transendothelial migration (540)
- Axon guidance (536)
- GnRH signaling pathway (532)
- Purine metabolism (531)
- Melanogenesis (524)
- Apoptosis (522)
- Small cell lung cancer (521)
- Adherens junction (519)
- Bladder cancer (505)
- Gap junction (482)
- VEGF signaling pathway (481)
- Acute myeloid leukemia (461)
- Long-term depression (451)
- Fc gamma R-mediated phagocytosis (450)
- Long-term potentiation (444)
- Glycolysis / Gluconeogenesis (430)
- Dilated cardiomyopathy (427)
- Cell adhesion molecules (CAMs) (420)
- Primary immunodeficiency (404)
- Toll-like receptor signaling pathway (401)
- Oocyte meiosis (393)
- Amino sugar and nucleotide sugar metabolism (387)
- Arrhythmogenic right ventricular cardiomyopathy (ARVC) (387)
- Starch and sucrose metabolism (384)
- Homologous recombination (362)
- Lysosome (359)
- Phosphatidylinositol signaling system (353)
- Hypertrophic cardiomyopathy (HCM) (340)
- Galactose metabolism (322)
- Maturity onset diabetes of the young (319)
- Adipocytokine signaling pathway (312)
- Basal cell carcinoma (311)
- Amyotrophic lateral sclerosis (ALS) (307)
- Viral myocarditis (300)
- Dorso-ventral axis formation (299)
- Hematopoietic cell lineage (297)
- Pyrimidine metabolism (295)
- Parkinson's disease (289)
- Oxidative phosphorylation (285)
- Spliceosome (281)
- Notch signaling pathway (280)
- Inositol phosphate metabolism (269)
- ECM-receptor interaction (263)
- Systemic lupus erythematosus (252)
- PPAR signaling pathway (248)
- TGF-beta signaling pathway (243)
- Epithelial cell signaling in Helicobacter pylori infection (236)
- Cardiac muscle contraction (235)
- Vibrio cholerae infection (232)
- NOD-like receptor signaling pathway (221)
- Glycerophospholipid metabolism (211)
- Pathogenic Escherichia coli infection (207)
- RIG-I-like receptor signaling pathway (205)
- Taste transduction (199)
- Antigen processing and presentation (196)
- Ribosome (193)
- Complement and coagulation cascades (190)
- Drug metabolism - cytochrome P450 (188)
- Metabolism of xenobiotics by cytochrome P450 (182)
- Arachidonic acid metabolism (160)
- Cytosolic DNA-sensing pathway (157)
- Glutathione metabolism (157)
- RNA degradation (157)
- Citrate cycle (TCA cycle) (155)
- Drug metabolism - other enzymes (154)
- Nucleotide excision repair (154)
- Retinol metabolism (151)
- ABC transporters (148)
- Arginine and proline metabolism (148)
- Hedgehog signaling pathway (144)
- N-Glycan biosynthesis (138)
- Tyrosine metabolism (135)
- Glycerolipid metabolism (130)
- Lysine degradation (127)
- Pyruvate metabolism (126)
- Base excision repair (125)
- Prion diseases (125)
- Valine (125)
- Fatty acid metabolism (123)
- Sphingolipid metabolism (119)
- Autoimmune thyroid disease (116)
- Type I diabetes mellitus (112)
- Cysteine and methionine metabolism (110)
- Proteasome (108)
- Tryptophan metabolism (106)
- leucine and isoleucine degradation (104)
- Porphyrin and chlorophyll metabolism (96)
- Glycosphingolipid biosynthesis - lacto and neolacto series (94)
- Aminoacyl-tRNA biosynthesis (91)
- Basal transcription factors (91)
- Graft-versus-host disease (91)
- DNA replication (90)
- Androgen and estrogen metabolism (89)
- Propanoate metabolism (89)
- Ether lipid metabolism (87)
- SNARE interactions in vesicular transport (87)
- Fructose and mannose metabolism (86)
- Allograft rejection (84)
- Alanine (82)
- Histidine metabolism (82)
- aspartate and glutamate metabolism (82)
- Glycine (77)
- serine and threonine metabolism (77)
- Selenoamino acid metabolism (76)
- Phenylalanine metabolism (75)
- Nitrogen metabolism (74)
- Butanoate metabolism (71)
- Glycosaminoglycan degradation (68)
- RNA polymerase (68)
- Pentose phosphate pathway (67)
- Keratan sulfate biosynthesis (64)
- Pentose and glucuronate interconversions (64)
- Linoleic acid metabolism (62)
- Glycosylphosphatidylinositol(GPI)-anchor biosynthesis (61)
- Nicotinate and nicotinamide metabolism (61)
- Regulation of autophagy (60)
- Ascorbate and aldarate metabolism (58)
- One carbon pool by folate (56)
- O-Glycan biosynthesis (55)
- Biosynthesis of unsaturated fatty acids (52)
- Steroid biosynthesis (52)
- Asthma (51)
- Pantothenate and CoA biosynthesis (51)
- beta-Alanine metabolism (50)
- Chondroitin sulfate biosynthesis (49)
- Heparan sulfate biosynthesis (48)
- Primary bile acid biosynthesis (48)
- Riboflavin metabolism (46)
- Other glycan degradation (45)
- alpha-Linolenic acid metabolism (42)
- Renin-angiotensin system (41)
- Limonene and pinene degradation (40)
- Non-homologous end-joining (40)
- Protein export (39)
- Glycosphingolipid biosynthesis - ganglio series (38)
- Glyoxylate and dicarboxylate metabolism (37)
- Terpenoid backbone biosynthesis (37)
- Cyanoamino acid metabolism (35)
- Glycosphingolipid biosynthesis - globo series (35)
- Sulfur metabolism (35)
- Circadian rhythm - mammal (34)
- Taurine and hypotaurine metabolism (34)
- leucine and isoleucine biosynthesis (31)
- Thiamine metabolism (26)
- Folate biosynthesis (23)
- C21-Steroid hormone metabolism (22)
- Caffeine metabolism (20)
- Fatty acid biosynthesis (20)
- Synthesis and degradation of ketone bodies (19)
- Fatty acid elongation in mitochondria (17)
- Methane metabolism (16)
- O-Mannosyl glycan biosynthesis (14)
- Lipoic acid metabolism (13)
- Lysine biosynthesis (13)
- Phenylalanine (13)
- tyrosine and tryptophan biosynthesis (13)
- Ubiquinone and other terpenoid-quinone biosynthesis (11)
- Biotin metabolism (10)
- D-Glutamine and D-glutamate metabolism (9)
- Vitamin B6 metabolism (8)
- D-Arginine and D-ornithine metabolism (1)
