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Species
Target Symbol
- BRCA1 (395)
- BTK (295)
- BRCA2 (277)
- GCK (255)
- TSC2 (248)
- MEN1 (242)
- MLH1 (241)
- MSH2 (215)
- RET (183)
- NOTCH3 (159)
- NF2 (99)
- MSH6 (88)
- STK11 (82)
- PI 3 KINASE CATALYTIC SUBUNIT ALPHA (67)
- WT1 (64)
- FGFR1 (63)
- E4 (61)
- FH (61)
- GNAS (60)
- L2 (60)
- L1 (50)
- CREM (45)
- PTEN (45)
- EGFR (44)
- ERCC2 (40)
- E3 (39)
- VEGFA (39)
- CTNNB1 (36)
- FLT4 (36)
- BRAF (35)
- E1 (35)
- CACNA1C (34)
- CACNA1G (33)
- E6 (32)
- E7 (32)
- KCNMA1 (32)
- TERT (32)
- E2 (31)
- CDKN2A (26)
- CTNND1 (26)
- NRG1 (26)
- PCDH15 (26)
- UTY (26)
- CBL (25)
- TPM1 (25)
- L4 (24)
- PRKCG (24)
- HRAS (23)
- IKAROS (23)
- KRAS (23)
- TNNT3 (23)
- BDNF (21)
- HYPOTHETICAL PROTEIN (21)
- L3 (21)
- DISC1 (20)
- KCNJ15 (20)
- RAF1 (20)
- NRAS (19)
- PLAGL1 (19)
- ST3GAL3 (19)
- DYNC1I2 (18)
- FGFR2 (18)
- NFATC2 (18)
- PRKCBP1 (18)
- ROR2 (18)
- TRPM3 (18)
- UBE2V1 (18)
- BIM (17)
- KCNQ2 (17)
- MIER1 (17)
- PDLIM5 (17)
- RUNX1T1 (17)
- SYTL2 (17)
- ANK1 (16)
- ARPP21 (16)
- ATF2 (16)
- ATP2C1 (16)
- BORIS (16)
- EMA (16)
- HMGA1 (16)
- IFI27 (16)
- LDB3 (16)
- ODF2 (16)
- PAK3 (16)
- SORBS1 (16)
- TPD52L2 (16)
- ZNF83 (16)
- ALK (15)
- ANKS1B (15)
- CDKN1C (15)
- DNMT3B (15)
- IKZF3 (15)
- PARD3 (15)
- PRKACB (15)
- TCF7L2 (15)
- TNIP1 (15)
- VP1 (15)
- VP2 (15)
- 3C (14)
- BETA CATENIN (14)
Mutants
Families
- Druggable Genome (11378)
- Transmembrane (5679)
- Transcription Factors (3321)
- Protein Kinase (1517)
- Secreted Protein (1134)
- Stem cell - Pluripotency (634)
- ES Cell Differentiation/IPS (466)
- Protease (409)
- GPCR (320)
- Phosphatase (237)
- Ion Channels: Other (134)
- Nuclear Hormone Receptor (116)
- Adult stem cells (105)
- Ion Channels: Potassium (81)
- Cancer stem cells (69)
- Ion Channels: Calcium (68)
- Embryonic stem cells (60)
- Stem cell relevant signaling - JAK/STAT signaling pathway (56)
- Ion Channels: Cys-loop Receptors (53)
- Ion Channels: Transient receptor potential (43)
- P450 (32)
- Induced pluripotent stem cells (30)
- Ion Channels: Glutamate Receptors (30)
- Stem cell relevant signaling - DSL/Notch pathway (23)
- Ion Channels: Sodium (20)
- Stem cell relevant signaling - TGFb/BMP signaling pathway (17)
- Stem cell relevant signaling - Wnt Signaling pathway (15)
- Ion Channels: ATP Receptors (10)
- Ion Channels: Cyclic nucleotide gated (9)
Pathways
- Pathways in cancer (1981)
- Metabolic pathways (1306)
- Colorectal cancer (900)
- Insulin signaling pathway (875)
- Endometrial cancer (678)
- MAPK signaling pathway (640)
- Pancreatic cancer (614)
- Focal adhesion (604)
- Ubiquitin mediated proteolysis (598)
- Regulation of actin cytoskeleton (565)
- Mismatch repair (562)
- B cell receptor signaling pathway (552)
- Prostate cancer (533)
- Fc epsilon RI signaling pathway (527)
- mTOR signaling pathway (519)
- Endocytosis (505)
- Melanoma (489)
- Type II diabetes mellitus (437)
- ErbB signaling pathway (430)
- p53 signaling pathway (429)
- Glioma (420)
- Chemokine signaling pathway (406)
- Thyroid cancer (404)
- Natural killer cell mediated cytotoxicity (388)
- Calcium signaling pathway (382)
- Renal cell carcinoma (381)
- Non-small cell lung cancer (377)
- Chronic myeloid leukemia (367)
- Neurotrophin signaling pathway (358)
- Tight junction (351)
- Cytokine-cytokine receptor interaction (348)
- Progesterone-mediated oocyte maturation (343)
- T cell receptor signaling pathway (340)
- Primary immunodeficiency (335)
- Gap junction (320)
- Neuroactive ligand-receptor interaction (319)
- Melanogenesis (318)
- Vascular smooth muscle contraction (312)
- GnRH signaling pathway (311)
- Homologous recombination (309)
- Long-term depression (307)
- Bladder cancer (305)
- Glycolysis / Gluconeogenesis (304)
- Acute myeloid leukemia (301)
- Adherens junction (301)
- Olfactory transduction (300)
- Starch and sucrose metabolism (300)
- Amino sugar and nucleotide sugar metabolism (299)
- VEGF signaling pathway (296)
- Leukocyte transendothelial migration (291)
- Maturity onset diabetes of the young (274)
- Long-term potentiation (273)
- Galactose metabolism (272)
- Jak-STAT signaling pathway (257)
- Axon guidance (255)
- Dorso-ventral axis formation (251)
- Wnt signaling pathway (249)
- Small cell lung cancer (239)
- Fc gamma R-mediated phagocytosis (235)
- Phosphatidylinositol signaling system (213)
- Cell cycle (205)
- Apoptosis (203)
- Notch signaling pathway (202)
- Alzheimer's disease (200)
- Toll-like receptor signaling pathway (196)
- Dilated cardiomyopathy (194)
- Purine metabolism (192)
- Huntington's disease (186)
- Arrhythmogenic right ventricular cardiomyopathy (ARVC) (178)
- Inositol phosphate metabolism (171)
- Adipocytokine signaling pathway (163)
- Cell adhesion molecules (CAMs) (160)
- Oocyte meiosis (149)
- Hypertrophic cardiomyopathy (HCM) (125)
- Vibrio cholerae infection (121)
- Viral myocarditis (119)
- Lysosome (118)
- Epithelial cell signaling in Helicobacter pylori infection (110)
- Pyrimidine metabolism (109)
- Basal cell carcinoma (108)
- Taste transduction (107)
- ECM-receptor interaction (105)
- Citrate cycle (TCA cycle) (101)
- Pathogenic Escherichia coli infection (100)
- Hematopoietic cell lineage (98)
- Parkinson's disease (95)
- Oxidative phosphorylation (92)
- PPAR signaling pathway (91)
- Amyotrophic lateral sclerosis (ALS) (84)
- Spliceosome (84)
- TGF-beta signaling pathway (84)
- Cardiac muscle contraction (82)
- Nucleotide excision repair (79)
- Glycerophospholipid metabolism (76)
- NOD-like receptor signaling pathway (75)
- Drug metabolism - cytochrome P450 (70)
- ABC transporters (69)
- RIG-I-like receptor signaling pathway (68)
- Metabolism of xenobiotics by cytochrome P450 (67)
- Systemic lupus erythematosus (67)
- Glutathione metabolism (65)
- Prion diseases (62)
- RNA degradation (62)
- Retinol metabolism (58)
- Arachidonic acid metabolism (57)
- Complement and coagulation cascades (56)
- Drug metabolism - other enzymes (55)
- Cytosolic DNA-sensing pathway (53)
- N-Glycan biosynthesis (51)
- Lysine degradation (50)
- Ribosome (50)
- Arginine and proline metabolism (49)
- Tyrosine metabolism (48)
- Base excision repair (47)
- Antigen processing and presentation (45)
- Hedgehog signaling pathway (45)
- Pyruvate metabolism (43)
- Fatty acid metabolism (42)
- Glycerolipid metabolism (41)
- Sphingolipid metabolism (40)
- Cysteine and methionine metabolism (38)
- Autoimmune thyroid disease (36)
- Porphyrin and chlorophyll metabolism (35)
- Type I diabetes mellitus (35)
- Valine (35)
- Basal transcription factors (32)
- DNA replication (32)
- Tryptophan metabolism (32)
- RNA polymerase (31)
- Aminoacyl-tRNA biosynthesis (30)
- Proteasome (30)
- leucine and isoleucine degradation (30)
- Androgen and estrogen metabolism (29)
- Glycosphingolipid biosynthesis - lacto and neolacto series (29)
- Pentose and glucuronate interconversions (28)
- Phenylalanine metabolism (28)
- Propanoate metabolism (28)
- Allograft rejection (27)
- Histidine metabolism (27)
- Fructose and mannose metabolism (26)
- Selenoamino acid metabolism (26)
- Graft-versus-host disease (25)
- Nitrogen metabolism (25)
- Ether lipid metabolism (24)
- Glycine (24)
- Steroid biosynthesis (24)
- serine and threonine metabolism (24)
- SNARE interactions in vesicular transport (23)
- Ascorbate and aldarate metabolism (22)
- Glycosaminoglycan degradation (22)
- Keratan sulfate biosynthesis (22)
- Pantothenate and CoA biosynthesis (22)
- Alanine (21)
- Glycosylphosphatidylinositol(GPI)-anchor biosynthesis (21)
- One carbon pool by folate (21)
- aspartate and glutamate metabolism (21)
- Pentose phosphate pathway (20)
- Nicotinate and nicotinamide metabolism (18)
- Chondroitin sulfate biosynthesis (17)
- Linoleic acid metabolism (17)
- Non-homologous end-joining (17)
- Regulation of autophagy (17)
- Riboflavin metabolism (17)
- Biosynthesis of unsaturated fatty acids (16)
- Butanoate metabolism (16)
- Cyanoamino acid metabolism (16)
- Circadian rhythm - mammal (15)
- Heparan sulfate biosynthesis (15)
- Primary bile acid biosynthesis (15)
- Protein export (15)
- Asthma (14)
- Glycosphingolipid biosynthesis - ganglio series (14)
- Other glycan degradation (14)
- beta-Alanine metabolism (14)
- Taurine and hypotaurine metabolism (13)
- Limonene and pinene degradation (12)
- O-Glycan biosynthesis (12)
- alpha-Linolenic acid metabolism (12)
- Glycosphingolipid biosynthesis - globo series (11)
- Glyoxylate and dicarboxylate metabolism (11)
- Renin-angiotensin system (11)
- Terpenoid backbone biosynthesis (9)
- Lysine biosynthesis (8)
- Thiamine metabolism (8)
- leucine and isoleucine biosynthesis (8)
- Fatty acid biosynthesis (7)
- Folate biosynthesis (7)
- O-Mannosyl glycan biosynthesis (7)
- Biotin metabolism (6)
- Sulfur metabolism (6)
- Lipoic acid metabolism (5)
- Methane metabolism (5)
- Phenylalanine (5)
- Synthesis and degradation of ketone bodies (5)
- tyrosine and tryptophan biosynthesis (5)
- Caffeine metabolism (4)
- D-Glutamine and D-glutamate metabolism (4)
- Fatty acid elongation in mitochondria (4)
- C21-Steroid hormone metabolism (3)
- Vitamin B6 metabolism (2)
- Ubiquinone and other terpenoid-quinone biosynthesis (1)