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cDNA Clones

Expression Plasmids

Mutant ORF Clones

Human

RET

EGFR

CBL

FGFR2

NEDD4 2

HRAS

MET

BETA ARRESTIN 2

GRK1

GIT2

GRK4

LDL RECEPTOR

P21 RAS

VEGF RECEPTOR 1

FGFR3

MDM2

FGFR4

PKC ZETA

ACTIVIN A RECEPTOR TYPE IC

CBLB

CD117

ACTIVIN A RECEPTOR TYPE IB

ALIX

DNAJC6

DYNAMIN 1

EGF

ITCH

NEDD4

PIP5K1 ALPHA

PIP5K3

RAB5B

RAB5C

SH3 CONTAINING GRB 2 LIKE 1 PROTEIN

SH3KBP1

TRKA

USP8

ERBB 3

GIT1

GRK6

PHOSPHOLIPASE D2

PIP5KI GAMMA

SMURF1

AMSH

CCR5

CD71

CDC42

CLTCL1

CXCR4

DAB2

EHD1

ERBB 4

IGF1 RECEPTOR

MCSF RECEPTOR

PAR6

RAB11A

RAB11FIP1

RAB4

SRC

TGF BETA RECEPTOR I

TGF BETA RECEPTOR II

AP2B1

AP2M1

BETA 1 ADRENERGIC RECEPTOR

BETA ARRESTIN 1

CBL C

CXCR2

EPS15

GRK5

PARD6G

PDGF RECEPTOR ALPHA

PIP5K1 BETA

RAB5

TRAF6

TSG101

VEGF RECEPTOR 2

ARH

BETA 2 ADRENERGIC RECEPTOR

BETA 3 ADRENERGIC RECEPTOR

BMP2

CHMP1B

CSF1R

CXCR1

GRK2

GRK3

GRK7

HGS

IL2 RECEPTOR ALPHA

IL2 RECEPTOR BETA

IL2 RECEPTOR GAMMA

PIP5K2 BETA

PKC IOTA

RAB11

RAB22A

RAB31

SMURF 2

THROMBIN RECEPTOR

Myc-DDK

TurboGFP

DDK-His

pCMV6-Entry

pCMV6-AC-GFP

pCMV6-XL5-DDK-His

No

Yes

TrueORF

TrueClone

TrueORF Gold, TrueORF

Druggable Genome

Protein Kinase

Transmembrane

Secreted Protein

ES Cell Differentiation/IPS

Adult stem cells

Transcription Factors

Stem cell relevant signaling - JAK/STAT signaling pathway

Cancer stem cells

GPCR

Stem cell - Pluripotency

Embryonic stem cells

Protease

Induced pluripotent stem cells

Stem cell relevant signaling - TGFb/BMP signaling pathway

Pathways in cancer

Metabolic pathways

MAPK signaling pathway

Colorectal cancer

Insulin signaling pathway

Focal adhesion

Endometrial cancer

Regulation of actin cytoskeleton

Pancreatic cancer

Cytokine-cytokine receptor interaction

Neuroactive ligand-receptor interaction

Prostate cancer

Calcium signaling pathway

Ubiquitin mediated proteolysis

Melanoma

Neurotrophin signaling pathway

Chemokine signaling pathway

B cell receptor signaling pathway

p53 signaling pathway

Glioma

Fc epsilon RI signaling pathway

Endocytosis

ErbB signaling pathway

Chronic myeloid leukemia

Wnt signaling pathway

Progesterone-mediated oocyte maturation

Non-small cell lung cancer

Type II diabetes mellitus

mTOR signaling pathway

Mismatch repair

Natural killer cell mediated cytotoxicity

Thyroid cancer

T cell receptor signaling pathway

Jak-STAT signaling pathway

Renal cell carcinoma

Apoptosis

Bladder cancer

GnRH signaling pathway

Small cell lung cancer

Cell cycle

Vascular smooth muscle contraction

Adherens junction

Melanogenesis

Gap junction

VEGF signaling pathway

Axon guidance

Leukocyte transendothelial migration

Tight junction

Long-term depression

Long-term potentiation

Acute myeloid leukemia

Primary immunodeficiency

Glycolysis / Gluconeogenesis

Toll-like receptor signaling pathway

Fc gamma R-mediated phagocytosis

Alzheimer's disease

Dilated cardiomyopathy

Purine metabolism

Homologous recombination

Phosphatidylinositol signaling system

Huntington's disease

Oocyte meiosis

Arrhythmogenic right ventricular cardiomyopathy (ARVC)

Starch and sucrose metabolism

Galactose metabolism

Amino sugar and nucleotide sugar metabolism

Maturity onset diabetes of the young

Amyotrophic lateral sclerosis (ALS)

Adipocytokine signaling pathway

Basal cell carcinoma

Dorso-ventral axis formation

Hematopoietic cell lineage

Cell adhesion molecules (CAMs)

Hypertrophic cardiomyopathy (HCM)

Inositol phosphate metabolism

Olfactory transduction

Notch signaling pathway

ECM-receptor interaction

TGF-beta signaling pathway

Lysosome

NOD-like receptor signaling pathway

Epithelial cell signaling in Helicobacter pylori infection

PPAR signaling pathway

Taste transduction

Complement and coagulation cascades

Viral myocarditis

Cardiac muscle contraction

Pathogenic Escherichia coli infection

RIG-I-like receptor signaling pathway

ABC transporters

Vibrio cholerae infection

Pyrimidine metabolism

Hedgehog signaling pathway

Nucleotide excision repair

Drug metabolism - cytochrome P450

Glycerophospholipid metabolism

Arachidonic acid metabolism

Metabolism of xenobiotics by cytochrome P450

Base excision repair

Citrate cycle (TCA cycle)

Cytosolic DNA-sensing pathway

Tyrosine metabolism

Prion diseases

Arginine and proline metabolism

Parkinson's disease

Retinol metabolism

Glycerolipid metabolism

Valine

Drug metabolism - other enzymes

Antigen processing and presentation

Lysine degradation

Fatty acid metabolism

Cysteine and methionine metabolism

Autoimmune thyroid disease

leucine and isoleucine degradation

Glutathione metabolism

Pyruvate metabolism

Systemic lupus erythematosus

Sphingolipid metabolism

Tryptophan metabolism

Type I diabetes mellitus

Histidine metabolism

Fructose and mannose metabolism

SNARE interactions in vesicular transport

Propanoate metabolism

Nitrogen metabolism

Proteasome

Butanoate metabolism

Phenylalanine metabolism

Alanine

Aminoacyl-tRNA biosynthesis

aspartate and glutamate metabolism

Allograft rejection

Linoleic acid metabolism

Oxidative phosphorylation

Pentose phosphate pathway

Androgen and estrogen metabolism

Ether lipid metabolism

Renin-angiotensin system

DNA replication

Riboflavin metabolism

Selenoamino acid metabolism

Regulation of autophagy

Steroid biosynthesis

Graft-versus-host disease

Spliceosome

Non-homologous end-joining

Porphyrin and chlorophyll metabolism

Glycosaminoglycan degradation

Other glycan degradation

beta-Alanine metabolism

Circadian rhythm - mammal

Glycine

Pantothenate and CoA biosynthesis

serine and threonine metabolism

Primary bile acid biosynthesis

Ribosome

N-Glycan biosynthesis

leucine and isoleucine biosynthesis

Terpenoid backbone biosynthesis

alpha-Linolenic acid metabolism

Basal transcription factors

C21-Steroid hormone metabolism

RNA degradation

Asthma

Ascorbate and aldarate metabolism

Folate biosynthesis

Limonene and pinene degradation

Nicotinate and nicotinamide metabolism

One carbon pool by folate

Protein export

Fatty acid biosynthesis

Pentose and glucuronate interconversions

Synthesis and degradation of ketone bodies

Glycosphingolipid biosynthesis - ganglio series

Glyoxylate and dicarboxylate metabolism

Thiamine metabolism

Biosynthesis of unsaturated fatty acids

Taurine and hypotaurine metabolism

Glycosphingolipid biosynthesis - globo series

Glycosphingolipid biosynthesis - lacto and neolacto series

Phenylalanine

tyrosine and tryptophan biosynthesis

Caffeine metabolism

Heparan sulfate biosynthesis

Ubiquinone and other terpenoid-quinone biosynthesis

Fatty acid elongation in mitochondria

Sulfur metabolism

Biotin metabolism

Glycosylphosphatidylinositol(GPI)-anchor biosynthesis

Methane metabolism

Chondroitin sulfate biosynthesis

RNA polymerase

Lysine biosynthesis

O-Glycan biosynthesis

Vitamin B6 metabolism

D-Arginine and D-ornithine metabolism

D-Glutamine and D-glutamate metabolism

Keratan sulfate biosynthesis

Neomycin

None

1

Yes

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