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Species
Target Symbol
- P53 (99)
- EGFR (31)
- KRAS (22)
- VEGFA (22)
- PLAGL1 (20)
- CD44 (19)
- CD46 (17)
- KCNJ15 (16)
- MET (16)
- BETA CATENIN (15)
- DISC1 (15)
- ALPHA DYSTROGLYCAN (14)
- BDNF (14)
- HNF 4 ALPHA (14)
- MORTALITY FACTOR 4 LIKE 2 (14)
- NRAS (14)
- SLC16A3 (14)
- SPHK1 (14)
- CEACAM1 (13)
- MYADM (13)
- PI 3 KINASE CATALYTIC SUBUNIT ALPHA (13)
- RHOH (13)
- RUNX1T1 (13)
- TFEB (13)
- FGFR1 (12)
- FGFR2 (12)
- HEXIM2 (12)
- MU OPIOID RECEPTOR (12)
- PTGER3 (12)
- SYNTABULIN (12)
- YAP1 (12)
- B RAF (11)
- BHLHB9 (11)
- CCR6 (11)
- DNMT3B (11)
- EIF5A (11)
- ESTROGEN RELATED RECEPTOR GAMMA (11)
- ISLR2 (11)
- MID1 (11)
- NRG1 (11)
- PAX6 (11)
- PEX2 (11)
- RNF146 (11)
- STEAP2 (11)
- BIN1 (10)
- CAMK2G (10)
- CD36 (10)
- CD82 (10)
- FGFR3 (10)
- FIGNL1 (10)
- GAPDH (10)
- IGF2 (10)
- IL1RAP (10)
- KCNE1 (10)
- LAMP2 (10)
- MAX (10)
- MEF2C (10)
- MUSK (10)
- PMP22 (10)
- RAB23 (10)
- RET (10)
- RUNX2 (10)
- SLITRK2 (10)
- SOCS2 (10)
- TGIF (10)
- TJAP1 (10)
- TMEM9 (10)
- ANO6 (9)
- C11ORF51 (9)
- C19ORF48 (9)
- CAMK2B (9)
- CAMK2D (9)
- CARHSP1 (9)
- CTNND1 (9)
- DAG1 (9)
- FAM156A (9)
- FGF1 (9)
- FUT7 (9)
- GLUCOCORTICOID RECEPTOR (9)
- GPR19 (9)
- GROWTH HORMONE RECEPTOR (9)
- HHAT (9)
- KCNJ1 (9)
- KCNK2 (9)
- LY6E (9)
- MIER1 (9)
- MITF (9)
- NF2 (9)
- NRP2 (9)
- NUMB (9)
- P21 RAS (9)
- P311 (9)
- PITX2 (9)
- SIRT3 (9)
- SSH3BP1 (9)
- TAU (9)
- TOR1AIP2 (9)
- TRP63 (9)
- TXNRD1 (9)
- 5HT4 RECEPTOR (8)
Vectors
Mutants
Families
- Druggable Genome (10044)
- Transmembrane (6680)
- Transcription Factors (2729)
- Secreted Protein (1641)
- Protein Kinase (916)
- ES Cell Differentiation/IPS (659)
- Protease (571)
- GPCR (564)
- Stem cell - Pluripotency (544)
- Phosphatase (242)
- Ion Channels: Other (190)
- Adult stem cells (173)
- Nuclear Hormone Receptor (137)
- Ion Channels: Potassium (126)
- Embryonic stem cells (123)
- Cancer stem cells (101)
- Ion Channels: Cys-loop Receptors (75)
- P450 (68)
- Induced pluripotent stem cells (65)
- Stem cell relevant signaling - JAK/STAT signaling pathway (58)
- Ion Channels: Transient receptor potential (42)
- Stem cell relevant signaling - DSL/Notch pathway (40)
- Stem cell relevant signaling - TGFb/BMP signaling pathway (34)
- Ion Channels: Glutamate Receptors (33)
- Ion Channels: Sodium (27)
- Stem cell relevant signaling - Wnt Signaling pathway (26)
- Ion Channels: Calcium (22)
- Ion Channels: Cyclic nucleotide gated (13)
- Ion Channels: ATP Receptors (12)
Pathways
- Metabolic pathways (1362)
- Pathways in cancer (853)
- MAPK signaling pathway (655)
- Neuroactive ligand-receptor interaction (489)
- Cytokine-cytokine receptor interaction (469)
- Focal adhesion (415)
- Regulation of actin cytoskeleton (415)
- Neurotrophin signaling pathway (401)
- Prostate cancer (382)
- Wnt signaling pathway (367)
- Olfactory transduction (357)
- Colorectal cancer (354)
- Chemokine signaling pathway (352)
- Calcium signaling pathway (345)
- Melanoma (334)
- Huntington's disease (333)
- Endocytosis (332)
- Pancreatic cancer (317)
- Glioma (308)
- Endometrial cancer (298)
- Chronic myeloid leukemia (295)
- Cell cycle (291)
- Apoptosis (287)
- Natural killer cell mediated cytotoxicity (286)
- Insulin signaling pathway (277)
- ErbB signaling pathway (274)
- Non-small cell lung cancer (274)
- Jak-STAT signaling pathway (271)
- Axon guidance (266)
- Bladder cancer (265)
- Alzheimer's disease (247)
- Small cell lung cancer (245)
- Tight junction (244)
- T cell receptor signaling pathway (243)
- GnRH signaling pathway (239)
- Melanogenesis (238)
- p53 signaling pathway (235)
- Progesterone-mediated oocyte maturation (233)
- Thyroid cancer (225)
- Cell adhesion molecules (CAMs) (221)
- Ubiquitin mediated proteolysis (221)
- Purine metabolism (218)
- Renal cell carcinoma (217)
- Gap junction (212)
- Leukocyte transendothelial migration (211)
- Adherens junction (209)
- Amyotrophic lateral sclerosis (ALS) (203)
- VEGF signaling pathway (203)
- Oocyte meiosis (199)
- Basal cell carcinoma (198)
- Toll-like receptor signaling pathway (193)
- Vascular smooth muscle contraction (192)
- Acute myeloid leukemia (186)
- B cell receptor signaling pathway (186)
- Fc epsilon RI signaling pathway (177)
- Long-term potentiation (174)
- Fc gamma R-mediated phagocytosis (173)
- Hematopoietic cell lineage (165)
- Long-term depression (165)
- Dilated cardiomyopathy (159)
- Parkinson's disease (155)
- Systemic lupus erythematosus (151)
- Lysosome (150)
- Arrhythmogenic right ventricular cardiomyopathy (ARVC) (144)
- Epithelial cell signaling in Helicobacter pylori infection (140)
- Hypertrophic cardiomyopathy (HCM) (138)
- Pyrimidine metabolism (137)
- ECM-receptor interaction (134)
- Spliceosome (134)
- TGF-beta signaling pathway (134)
- mTOR signaling pathway (134)
- Oxidative phosphorylation (133)
- Viral myocarditis (133)
- Adipocytokine signaling pathway (127)
- NOD-like receptor signaling pathway (124)
- Type II diabetes mellitus (119)
- Antigen processing and presentation (118)
- PPAR signaling pathway (115)
- Complement and coagulation cascades (113)
- RIG-I-like receptor signaling pathway (110)
- Phosphatidylinositol signaling system (101)
- Pathogenic Escherichia coli infection (100)
- Cardiac muscle contraction (93)
- Ribosome (89)
- Glycerophospholipid metabolism (86)
- Glycolysis / Gluconeogenesis (86)
- Dorso-ventral axis formation (83)
- Cytosolic DNA-sensing pathway (82)
- Inositol phosphate metabolism (82)
- ABC transporters (81)
- Vibrio cholerae infection (81)
- Drug metabolism - cytochrome P450 (79)
- Glutathione metabolism (79)
- Hedgehog signaling pathway (77)
- Taste transduction (76)
- Arachidonic acid metabolism (75)
- Metabolism of xenobiotics by cytochrome P450 (72)
- Notch signaling pathway (72)
- Type I diabetes mellitus (72)
- Autoimmune thyroid disease (71)
- Retinol metabolism (70)
- RNA degradation (69)
- N-Glycan biosynthesis (68)
- Arginine and proline metabolism (67)
- Primary immunodeficiency (65)
- Graft-versus-host disease (64)
- Tyrosine metabolism (64)
- Valine (62)
- Lysine degradation (61)
- Prion diseases (60)
- Sphingolipid metabolism (60)
- Allograft rejection (58)
- Drug metabolism - other enzymes (58)
- Maturity onset diabetes of the young (58)
- Pyruvate metabolism (57)
- Cysteine and methionine metabolism (56)
- Fatty acid metabolism (56)
- Glycerolipid metabolism (56)
- leucine and isoleucine degradation (53)
- Base excision repair (52)
- Starch and sucrose metabolism (50)
- SNARE interactions in vesicular transport (49)
- Amino sugar and nucleotide sugar metabolism (48)
- Ether lipid metabolism (48)
- Homologous recombination (48)
- Nucleotide excision repair (48)
- Proteasome (47)
- Tryptophan metabolism (47)
- Alanine (45)
- Androgen and estrogen metabolism (45)
- aspartate and glutamate metabolism (45)
- Citrate cycle (TCA cycle) (43)
- Aminoacyl-tRNA biosynthesis (42)
- Fructose and mannose metabolism (42)
- Porphyrin and chlorophyll metabolism (41)
- Nicotinate and nicotinamide metabolism (40)
- Propanoate metabolism (38)
- Asthma (37)
- Galactose metabolism (37)
- Regulation of autophagy (37)
- DNA replication (36)
- RNA polymerase (36)
- Glycosphingolipid biosynthesis - lacto and neolacto series (35)
- Butanoate metabolism (34)
- Glycine (34)
- serine and threonine metabolism (34)
- Glycosaminoglycan degradation (33)
- Phenylalanine metabolism (33)
- Selenoamino acid metabolism (33)
- Basal transcription factors (32)
- Linoleic acid metabolism (30)
- Mismatch repair (30)
- Pentose phosphate pathway (30)
- Histidine metabolism (29)
- Nitrogen metabolism (28)
- Non-homologous end-joining (28)
- O-Glycan biosynthesis (28)
- Renin-angiotensin system (27)
- Heparan sulfate biosynthesis (26)
- Chondroitin sulfate biosynthesis (25)
- Riboflavin metabolism (23)
- Biosynthesis of unsaturated fatty acids (22)
- Circadian rhythm - mammal (22)
- Glycosphingolipid biosynthesis - globo series (22)
- Keratan sulfate biosynthesis (22)
- beta-Alanine metabolism (22)
- Glycosphingolipid biosynthesis - ganglio series (21)
- Glycosylphosphatidylinositol(GPI)-anchor biosynthesis (21)
- Pentose and glucuronate interconversions (21)
- Primary bile acid biosynthesis (20)
- Steroid biosynthesis (20)
- One carbon pool by folate (19)
- Other glycan degradation (19)
- Pantothenate and CoA biosynthesis (19)
- alpha-Linolenic acid metabolism (18)
- Ascorbate and aldarate metabolism (17)
- C21-Steroid hormone metabolism (16)
- Glyoxylate and dicarboxylate metabolism (16)
- Sulfur metabolism (16)
- Terpenoid backbone biosynthesis (16)
- Limonene and pinene degradation (14)
- Taurine and hypotaurine metabolism (14)
- Synthesis and degradation of ketone bodies (13)
- leucine and isoleucine biosynthesis (13)
- Cyanoamino acid metabolism (12)
- Caffeine metabolism (11)
- Fatty acid biosynthesis (11)
- Folate biosynthesis (9)
- Phenylalanine (9)
- tyrosine and tryptophan biosynthesis (9)
- Fatty acid elongation in mitochondria (8)
- Protein export (8)
- Lipoic acid metabolism (7)
- Thiamine metabolism (7)
- Methane metabolism (6)
- Ubiquinone and other terpenoid-quinone biosynthesis (6)
- Vitamin B6 metabolism (6)
- Biotin metabolism (5)
- D-Glutamine and D-glutamate metabolism (3)
- Lysine biosynthesis (3)
- O-Mannosyl glycan biosynthesis (3)