Hirudo medicinalis Recombinant Protein

Specifications

Product Data
Species	Hirudo medicinalis
Protein Source	Pichia pastoris
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Y3-Q65
Tag	C-6His
Buffer	Supplied as a 0.2 um filtered solution of PBS pH7.4
Note	Recombinant Hirudo medicinalis Hirudin-1 is produced by Pichia pastoris. The target gene encoding Y3-Q65 is expressed with a 6His tag at the C terminus.
Stability	12 months from date of despatch
Reference Data
Summary	Hirudin is a secreted protein that belongs to the protease inhibitor I14 (hirudin) family. Hirudin is a potent thrombin-specific protease inhibitor. It forms a stable non-covalent complex with alpha-thrombin, thereby abolishing its ability to cleave fibrinogen. In nature, Hirudin is found in the salivary glands of Hirudo medicinalis that has a blood anticoagulant property. Hirudin can be used to treat heparin-induced thrombocytopenia.

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