Pig Recombinant Protein

Specifications

Product Data
Species	Pig
Protein Source	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) G23-L199
Tag	N-6His
Buffer	Supplied as a 0.2 um filtered solution of 2umM Tris-HCl, 30umM NaCl, 10% Glycerol, pH8.0
Note	Recombinant Pig Interleukin-11 is produced by E.coli. The target gene encoding G23-L199 is expressed with a 6His tag at the N terminus.
Stability	12 months from date of despatch
Reference Data
Summary	Interleukin 11 (IL-11) is a pleiotropic cytokine that belongs to the IL-6 family. As a thrombopoietic growth factor, IL-11 directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. IL-11 also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2, it activates a signaling cascade that promotes cell proliferation. The signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. IL-11 is found to improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute-phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation, and could be used as a therapeutic for osteoporosis.

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.