TNFRSF4 Human Recombinant Protein

Specifications

Product Data
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) OX40（Leu29-Ala216）+hFc（Glu99-Ala330）+6×His tag
Tag	C-Human Fc and 6×His
Predicted MW	47.2 kDa
Purity	> 95%
Buffer	Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose is added as protectants before lyophilization
Preparation	Affinity purification
Applications	Flow Cyt
Storage	Store the lyophilized protein at -20°C. After reconstitution, store the protein at -80°C for 12 months. Avoid repeated freezing and thawing.
Stability	12 months from date of despatch
Reference Data
Locus ID	7293
UniProt ID	P43489
Summary	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.

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