CD38 Human Recombinant Protein

Specifications

Product Data
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Val43-Ile300
Tag	C-His-Avi
Predicted MW	The protein has a predicted molecular weight of 33 kDa and migrates at approximately 35-45 kDa on SDS-PAGE with DTT-reduced conditions.
Concentration	25µg size is bottled at 0.2mg/mL concentration. 100 µg size is bottled at lot specific concentration.
Purity	>90%
Buffer	1xPBS buffer, pH7.4
Preparation	Affinity Ni-NTA
Applications	ELISA
Storage	An unopened vial can be stored at 4°C for 2 weeks or at -20°C and below for six months. This stock solution should be aliquoted and stored at ≤ -70°C to minimize the freeze/thaw cycles.
Stability	6 Months
Bioactivity	Positive The definition of the active protein (purified and biotinylated) is defined as the protein that can bind to its biological receptor/ligand. For conjugated protein, it is defined with its function to bind to the ScFv of the active CAR-transfected cells in flow cytometry test.
Reference Data
RefSeq	NP_001766.2
Locus ID	952
UniProt ID	P28907
Summary	Cluster of differentiation 38 (CD38) is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed in many immune cells including  B cells, T lymphocytes, and NK cells. CD38 is expressed at high levels in some organs like pancreas, liver, kidney, brain, testis, ovary. CD38 can function as either a cell surface receptor or as an enzyme. As the receptor, CD38 can activate T cells and promote cytokine production. As the multifunctional enzyme, CD38 can regulating calcium mediated signal transduction through the production of cyclic ADP-ribose (cADPR) in many types of cells. Clinically, elevated CD38 expression is prognostic marker in chronic lymphocytic leukemia.

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