ITM2B (NM_021999) Human Recombinant Protein

Specifications

Product Data
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Tyr76-Ser266
Tag	C-His
Predicted MW	23.3 kDa
Purity	>95% as determined by SDS-PAGE and Coomassie blue staining
Buffer	Filtered solution of a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Storage	Store at ≤-70°C, stable for 6 months after receipt.Store at ≤-70°C, stable for 3 months under sterile conditions after opening.Please minimize freeze-thaw cycles.
Stability	Stable for at least 3 months from date of receipt under proper storage and handling conditions.
Endotoxin	Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Reference Data
RefSeq	NP_068839
Locus ID	9445
UniProt ID	Q9Y287, A0A384MDP7
Refseq Size	1896
Cytogenetics	13q14.2
Refseq ORF	798
Synonyms	ABRI; BRI; BRI2; BRICD2B; E3-16; E25B; FBD; imBRI2; RDGCA
Summary	Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq, Oct 2009]
Protein Families	Druggable Genome, Transmembrane

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