TSH Receptor (TSHR) (NM_000369) Human Recombinant Protein

Specifications

Product Data
Species	Human
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) A DNA sequence from TrueORF clone, RC220499, encoding the region(Met22-Gly413) of TSHR
Tag	C-HUMAN
Predicted MW	74.6 kDa
Concentration	>0.05 µg/µL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	PBS, pH 7.4, 10% glycerol
Note	For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_000360
Locus ID	7253
UniProt ID	P16473, A0A0A0MTJ0
Refseq Size	4410
Cytogenetics	14q31.1
Refseq ORF	2292
Synonyms	CHNG1; hTSHR-I; LGR3
Summary	The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Autoimmune thyroid disease, Neuroactive ligand-receptor interaction

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