Inpp5f (NM_178641) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) >MR224434 protein sequence Red=Cloning site Green=Tags(s) MELFQAKDHYILQQGERALWCSRRDGGLQLRPATDLLLAWNPICLGLVEGVIGKIQLHSDLPWWLILIRQ KALVGKLPGDHEVCKVTKIAVLSLSEMEPQELELELCKKHHFGINKPEKIIPSPDDSKFLLKTFTNIKSN VSAPNKKKVKESKEKEKLERRLLEELLKMFMDSESFYYSLTYDLTNSVQRQSTGERDGRPLWQKVDDRFF WNKYMIQALTEIGTPDVDFWIIPIIQGFVQIEELVVNYNESSDDDKSSPETPPQDSTCVDDIHPRFLVAL ISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHHHTLSFIQTRGSVPVFWSQVGYRYNPRPRLDKS EKETVDCFCAHFEEQLKIYKKQVIVNLVDQAGREKIIGDAYLKQVLLFNNPKLTYVSFDFHEHCRGMKFE NVQTLTDAIHDIIIDMKWCWVDQAGVICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPE QPLPVKCNRTYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLSRFKDAYRQA VIDLMQGVPVTEDLYSIFTKEKEHEALHKESQRSHQELISQLLQSYMQLLLPGDEKFHGGWALVDCDPSL TDAAHRDVEVLLLLSNAAYYVAYYDDEVDKVNQYQRLGLEDLERIEIGPEPTLFGKPKFSCMRLHYRCKE AGGYFHTLRAVPRSPEEDGKDTLQCIAEMLQITKQAMGLDVPIIEKKLERKSSKPHEDIIGIRSQNQGSL AQGKSFLMSKFSSLNQKVKQTKSNVNIGNLRKLGNFTKPEMKVNFLKPNLKVNLWKSDSSLETMENPGVM GNKVQGESDGDISSDNDSYHSDEFLTNSKSEEDKQLANSLESVGPIDYILPSCGIIVSAPRLGSRSQSAS SIDVSTHAPSEAAAGPGSELGKGLESPLKKSPSADSIHTRTGFTKPMDVYCQRFVQDAQNKMNDLSEIRS VAQKSEEGSHKTNRVSNEETQSEPMGQTPPRPSQLNVSCSVAGPPFLSVEPVHSVLSQKTPSSGSSLLEL EAGLCVTPSSESSSSRAVSPFAKIRSSMVQVANITQAGLTHGINLAVAKVQKSPAEPEAVNEIQQNELKN MFTQCQTRIIQI TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-MYC/DDK
Predicted MW	127.6 kDa
Concentration	>0.05 µg/µL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note	For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_848756
Locus ID	101490
UniProt ID	Q8CDA1, B2RQ14
Refseq Size	4740
Cytogenetics	7 F3
Refseq ORF	3399
Synonyms	5830435P03Rik; AI115354; AW561896; cI-27; hSAC2; mKIAA0966; SAC2
Summary	Inositol 4-phosphatase which mainly acts on phosphatidylinositol 4-phosphate. May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol, for a sequential dephosphorylation of phosphatidylinositol 4,5-bisphosphate at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869668, PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (By similarity). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (By similarity). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (PubMed:19875726). May play a role as negative regulator of axon regeneration after central nervous system injuries (PubMed:26203138).[UniProtKB/Swiss-Prot Function]

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