hnRNP core protein A1 / HNRNPA1 (1-320, His-tag) Human Protein
CAT#: AR50236PU-N
hnRNP core protein A1 / HNRNPA1 (1-320, His-tag) human recombinant protein, 0.5 mg
Size: 100 ug
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CNY 17,930.00
货期*
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规格
Cited in 7 publications. |
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Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MGSSHHHHHH SSGLVPRGSH MGSMSKSESP KEPEQLRKLF IGGLSFETTD ESLRSHFEQW GTLTDCVVMR DPNTKRSRGF GFVTYATVEE VDAAMNARPH KVDGRVVEPK RAVSREDSQR PGAHLTVKKI FVGGIKEDTE EHHLRDYFEQ YGKIEVIEIM TDRGSGKKRG FAFVTFDDHD SVDKIVIQKY HTVNGHNCEV RKALSKQEMA SASSSQRGRS GSGNFGGGRG GGFGGNDNFG RGGNFSGRGG FGGSRGGGGY GGSGDGYNGF GNDGSNFGGG GSYNDFGNYN NQSSNFGPMK GGNFGGRSSG PYGGGGQYFA KPRNQGGYGG SSSSSSYGSG RRF
|
Tag | His-tag |
Predicted MW | 36.6 kDa |
Concentration | lot specific |
Purity | >85% by SDS - PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 40% glycerol, 0.15M NaCl, 1 mM DTT |
Preparation | Liquid purified protein |
Protein Description | Recombinant human HNRNPA1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography. |
Storage | Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_002127 |
Locus ID | 3178 |
UniProt ID | P09651, A0A024RB53 |
Cytogenetics | 12q13.13 |
Synonyms | ALS19; ALS20; hnRNP-A1; hnRNP A1; HNRPA1; HNRPA1L3; IBMPFD3; UP 1 |
Summary | This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport. The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing. Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20. Multiple alternatively spliced transcript variants have been found. There are numerous pseudogenes of this gene distributed throughout the genome. [provided by RefSeq, Feb 2016] |
Protein Pathways | Spliceosome |
Citations (7)
The use of this Proteins has been cited in the following citations: |
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Small molecules inhibitors of the heterogeneous ribonuclear protein A18 (hnRNP A18): a regulator of protein translation and an immune checkpoint
,null,
Nucleic Acids Research
,PubMed ID 33398344
[HNRNPA1]
|
Blocking of an intronic splicing silencer completely rescues IKBKAP exon 20 splicing in familial dysautonomia patient cells
,null,
Nucleic Acids Research
,PubMed ID 29762696
[HNRNPA1]
|
Heterogeneous nuclear ribonucleoprotein A1 post-transcriptionally regulates Drp1 expression in neuroblastoma cells
,null,
Biochimica et Biophysica Acta
,PubMed ID 26518267
[HNRNPA1]
|
Regulation of oncogenic KRAS signaling via a novel KRAS-integrin-linked kinase-hnRNPA1 regulatory loop in human pancreatic cancer cells.
,null,
Oncogene
,PubMed ID 26616862
[HNRNPA1]
|
hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling
,null,
Nucleic Acids Research
,PubMed ID 25324306
[HNRNPA1]
|
A three-state model for the regulation of telomerase by TERRA and hnRNPA1
,null,
Nucleic Acids Research
,PubMed ID 23935072
[HNRNPA1]
|
HNRNPA1 interacts with a 5? flanking distal element of interleukin 6 and up-regulates its basal transcription
,null,
Genes and immunity
,PubMed ID 23985572
[HNRNPA1]
|
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