CD22 Human Protein

Specifications

Product Data
Species	Human
Expression Host	CHO
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) SKWVFEHPET LYAWEGACVW IPCTYRALDG DLESFILFHN PEYNKN TSKF DGTRLYESTK DGKVPSEQKR VQFLGDKNKN CTLSIHPVHL N DSGQLGLRM ESKTEKWMER IHLNVSERPF PPHIQLPPEI QESQEVT LTC LLNFSCYGYP IQLQWLLEGV PMRQAAVTST SLTIKSVFTR SE LKFSPQWS HHGKIVTCQL QDADGKFLSN DTVQLNVKHT PKLEIKVT PS DAIVREGDSV TMTCEVSSSN PEYTTVSWLK DGTSLKKQNT FTL NLREVTK DQSGKYCCQV SNDVGPGRSE EVFLQVQYAP EPSTVQILH S PAVEGSQVEF LCMSLANPLP TNYTWYHNGK EMQGRTEEKV HIPK ILPWHA GTYSCVAENI LGTGQRGPGA ELDVQYPPKK VTTVIQNPMP IREGDTVTLS CNYNSSNPSV TRYEWKPHGA WEEPSLGVLK IQNVG WDNTT IACARCNSWC SWASPVALNV QYAPRDVRVR KIKPLSEIHS GNSVSLQCDF SSSHPKEVQF FWEKNGRLLG KESQLNFDSI SPEDAG SYSC WVNNSIGQTA SKAWTLEVLY APRRLRVSMS PGDQVMEGKS A TLTCESDAN PPVSHYTWFD WNNQSLPHHS QKLRLEPVKV QHSGAYW CQG TNSVGKGRSP LSTLTVYYSP ETIGRR
Predicted MW	75 kDa
Purity	>98% by SDS-PAGE & HPLC analysis
Buffer	Presentation State: Purified State: Lyophilized purified protein Buffer System: PBS without stabilizers
Preparation	Lyophilized purified protein
Protein Description	Recombinant Human CD22 is a soluble 75.0 kDa (666 amino acid residues) protein which corresponds to the extracellular domain of CD22.
Note	Centrifuge vials before opening!
Storage	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month  or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Bioactivity	Biological: Determined by its ability to inhibit the proliferation of Raji cells. The expected ED50 for this effect is 10-17 μg/ml.
Reference Data
Locus ID	79978
Cytogenetics	19q13.13
Synonyms	SIGLEC-2; SIGLEC2
Summary	CD22 is a 135 kDa B-cell restricted sialoglycoprotein that binds to oligosaccharides containing 2-6-linked sialic acid residues. It is present in the cytoplasm of nearly all B-lineage cells and is also expressed on the surface of B-cells during advance stages of differentiation. Although the exact physiological function of CD22 is unclear, it appears to play a role in B-cell activation and to act as an adhesion molecule. The potential therapeutic use of CD22 and anti-CD22 may be useful in diagnostic and/or treatment of leukemia, lymphoma, non-Hodgkin's lymphoma and certain autoimmune conditions. (Cesano A. and Gayko U. Semin. Oncol. Apr. 2003 (2): 253-257).

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