Kallikrein-3 / PSA / KLK3 (PSA-ACT Complex) Human Protein

Specifications

Product Data
Description	Kallikrein-3 / PSA / KLK3 (PSA-ACT Complex) human protein, 50 µg
Species	Human
Protein Source	Seminal Fluid
Purity	>95% purity by SDS Page
Buffer	Presentation State: Purified State: Liquid purified fraction Buffer System: 10 mM Sodium Acetate, 0.15M Sodium Chloride, pH 5.6, 0.05% (w/v) Sodium Azide
Preparation	Liquid purified fraction
Note	Caution: Status: Starting material was tested and found negative for antibodies to HIV and HBsAg. How ever, all human derived materila should be treated as potentially infectious.
Storage	Store at 2-8°C for up to 3 weeks. For long term storage, aliquot and store at -20°C for up to one year.
Reference Data
RefSeq	NP_001025218
Locus ID	354
Cytogenetics	19q13.33
Synonyms	APS; hK3; KLK2A1; PSA
Summary	Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. It encodes a single-chain glycoprotein, a protease which is synthesized in the epithelial cells of the prostate gland, and is present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. The serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Dec 2019]
Protein Families	Druggable Genome, Protease, Secreted Protein
Protein Pathways	Pathways in cancer, Prostate cancer

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