SH2B3 Mutant (R262W) Human Recombinant Protein

Specifications

Product Data
Description	Purified mutant recombinant protein of Human SH2B adaptor protein 3 (SH2B3), mutation at（R262W)
Species	Human
Expression Host	HEK293T
Expression cDNA Clone or AA Sequence	A DNA sequence from TrueORF clone, RC218359, encoding the full-length of SH2B3(R262W)
Tag	Myc-DDK
Predicted MW	63 kDa
Concentration	>0.05 µg/µL as determined by microplate Bradford method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Note	For culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage	Store at -80°C after receiving vials.
Stability	Stable for at least 12 months from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq	NP_005466.1
Locus ID	10019
Refseq Size	5423
Cytogenetics	12q24.12
Refseq ORF	1725
Synonyms	IDDM20; LNK
Summary	This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Protein Pathways	Neurotrophin signaling pathway

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