PIK3C2B (NM_002646) Human Mass Spec Standard

CAT#: PH318354

PIK3C2B MS Standard C13 and N15-labeled recombinant protein (NP_002637)



  View other "PIK3C2B" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
Transient overexpression lysate of phosphoinositide-3-kinase, class 2, beta polypeptide (PIK3C2B)
    • 100 ug

CNY 4,840.00


PIK3C2B mouse monoclonal antibody, clone OTI2G3 (formerly 2G3)
    • 100 ul

CNY 1,999.00
CNY 2,700.00

Specifications

Product Data
Description PIK3C2B MS Standard C13 and N15-labeled recombinant protein (NP_002637)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC218354
Predicted MW 184.6 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_002637
RefSeq Size 7618
RefSeq ORF 4902
Synonyms C2-PI3K
Locus ID 5287
Cytogenetics 1q32.1
Summary The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome
Protein Pathways Inositol phosphate metabolism, Metabolic pathways, Phosphatidylinositol signaling system
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