p15 INK4b (CDKN2B) (NM_078487) Human Mass Spec Standard

CAT#: PH317024

CDKN2B MS Standard C13 and N15-labeled recombinant protein (NP_511042)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description CDKN2B MS Standard C13 and N15-labeled recombinant protein (NP_511042)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC217024
Predicted MW 7.9 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_511042
RefSeq Size 4001
RefSeq ORF 234
Synonyms CDK4I; INK4B; MTS2; P15; p15INK4b; TP15
Locus ID 1030
Cytogenetics 9p21.3
Summary This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome
Protein Pathways Cell cycle, Pathways in cancer, Small cell lung cancer, TGF-beta signaling pathway
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