Amyloid Precursor Protein (APP) (NM_201414) Human Mass Spec Standard

CAT#: PH315147

APP MS Standard C13 and N15-labeled recombinant protein (NP_958817)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description APP MS Standard C13 and N15-labeled recombinant protein (NP_958817)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC215147
Predicted MW 76.9 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_958817
RefSeq Size 3416
RefSeq ORF 2085
Synonyms AAA; ABETA; ABPP; AD1; alpha-sAPP; APPI; CTFgamma; CVAP; PN-II; PN2; preA4
Locus ID 351
Cytogenetics 21q21.3
Summary This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
Protein Families Druggable Genome, Transmembrane
Protein Pathways Alzheimer's disease
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