IGF1 Receptor (IGF1R) (NM_000875) Human Mass Spec Standard

CAT#: PH314928

IGF1R MS Standard C13 and N15-labeled recombinant protein (NP_000866)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

Cited in 1 publication.

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Specifications

Product Data
Description IGF1R MS Standard C13 and N15-labeled recombinant protein (NP_000866)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC214928
Predicted MW 154.79 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_000866
RefSeq Size 4989
RefSeq ORF 4101
Synonyms CD221; IGFIR; IGFR; JTK13
Locus ID 3480
Cytogenetics 15q26.3
Summary This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways Adherens junction, Colorectal cancer, Endocytosis, Focal adhesion, Glioma, Long-term depression, Melanoma, Oocyte meiosis, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer
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Citations (1)

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