AMACR (NM_014324) Human Mass Spec Standard

CAT#: PH313437

AMACR MS Standard C13 and N15-labeled recombinant protein (NP_055139)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description AMACR MS Standard C13 and N15-labeled recombinant protein (NP_055139)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC213437
Predicted MW 42.7 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_055139
RefSeq Size 2534
RefSeq ORF 1155
Synonyms AMACRD; CBAS4; P504S; RACE; RM
Locus ID 23600
Cytogenetics 5p13.2
Summary This gene encodes a racemase. The encoded enzyme interconverts pristanoyl-CoA and C27-bile acylCoAs between their (R)- and (S)-stereoisomers. The conversion to the (S)-stereoisomers is necessary for degradation of these substrates by peroxisomal beta-oxidation. Encoded proteins from this locus localize to both mitochondria and peroxisomes. Mutations in this gene may be associated with adult-onset sensorimotor neuropathy, pigmentary retinopathy, and adrenomyeloneuropathy due to defects in bile acid synthesis. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the upstream neighboring C1QTNF3 (C1q and tumor necrosis factor related protein 3) gene. [provided by RefSeq, Mar 2011]
Protein Families Druggable Genome
Protein Pathways Metabolic pathways, Primary bile acid biosynthesis
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