PEN2 (PSENEN) (NM_172341) Human Mass Spec Standard

CAT#: PH303272

PSENEN MS Standard C13 and N15-labeled recombinant protein (NP_758844)



  View other "PEN2" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description PSENEN MS Standard C13 and N15-labeled recombinant protein (NP_758844)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC203272
Predicted MW 12 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_758844
RefSeq Size 834
RefSeq ORF 303
Synonyms ACNINV2; MDS033; MSTP064; PEN-2; PEN2
Locus ID 55851
Cytogenetics 19q13.12
Summary Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. Mutations resulting in haploinsufficiency for this gene cause familial acne inversa-2 (ACNINV2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Protein Families Druggable Genome, Transmembrane
Protein Pathways Alzheimer's disease, Notch signaling pathway
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