TGIF (TGIF1) (NM_173208) Human Mass Spec Standard

CAT#: PH301549

TGIF1 MS Standard C13 and N15-labeled recombinant protein (NP_775300)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description TGIF1 MS Standard C13 and N15-labeled recombinant protein (NP_775300)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC201549
Predicted MW 29.7 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_775300
RefSeq Size 1890
RefSeq ORF 816
Synonyms HPE4; TGIF
Locus ID 7050
Cytogenetics 18p11.31
Summary The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]
Protein Families Druggable Genome, Stem cell - Pluripotency, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transcription Factors
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