Dehydrodolichyl Diphosphate Synthase (DHDDS) (NM_024887) Human Mass Spec Standard

Specifications

Product Data
Description	DHDDS MS Standard C13 and N15-labeled recombinant protein (NP_079163)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC201430
Predicted MW	38.7 kDa
Protein Sequence	Sequence Link (showhide) >RC201430 protein sequence Red=Cloning site Green=Tags(s) MSWIKEGELSLWERFCANIIKAGPMPKHIAFIMDGNRRYAKKCQVERQEGHSQGFNKLAETLRWCLNLGI LEVTVYAFSIENFKRSKSEVDGLMDLARQKFSRLMEEKEKLQKHGVCIRVLGDLHLLPLDLQELIAQAVQ ATKNYNKCFLNVCFAYTSRHEISNAVREMAWGVEQGLLDPSDISESLLDKCLYTNRSPHPDILIRTSGEV RLSDFLLWQTSHSCLVFQPVLWPEYTFWNLFEAILQFQMNHSMLQKARDMYAEERKRQQLERDQATVTEQ LLREGLQASGDAQLRRTRLHKLSARREERVQGFLQALELKRADWLARLGTASA TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_079163
RefSeq Size	3343
RefSeq ORF	909
Synonyms	CIT; CPT; DEDSM; DS; hCIT; HDS; RP59
Locus ID	79947
Cytogenetics	1p36.11
Summary	The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Protein Pathways	Terpenoid backbone biosynthesis

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