TXNL4A (NM_006701) Human Mass Spec Standard

Specifications

Product Data
Description	TXNL4A MS Standard C13 and N15-labeled recombinant protein (NP_006692)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC200266
Predicted MW	16.8 kDa
Protein Sequence	Sequence Link (showhide) >RC200266 protein sequence Red=Cloning site Green=Tags(s) MSYMLPHLHNGWQVDQAILSEEDRVVVIRFGHDWDPTCMKMDEVLYSIAEKVKNFAVIYLVDITEVPDFN KMYELYDPCTVMFFFRNKHIMIDLGTGNNNKINWAMEDKQEMVDIIETVYRGARKGRGLVVSPKDYSTKY RY TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_006692
RefSeq Size	1415
RefSeq ORF	426
Synonyms	BMKS; DIB1; DIM1; SNRNP15; TXNL4; U5-15kD
Locus ID	10907
Cytogenetics	18q23
Summary	The protein encoded by this gene is a member of the U5 small ribonucleoprotein particle (snRNP), and is involved in pre-mRNA splicing. This protein contains a thioredoxin-like fold and it is expected to interact with multiple proteins. Protein-protein interactions have been observed with the polyglutamine tract-binding protein 1 (PQBP1). Mutations in both the coding region and promoter region of this gene have been associated with Burn-McKeown syndrome, which is a rare disorder characterized by craniofacial dysmorphisms, cardiac defects, hearing loss, and bilateral choanal atresia. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Protein Families	Druggable Genome
Protein Pathways	Spliceosome

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