Human Amino terminal enhancer of split (AES) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TLE5
Locus ID	166
Kit Components	GA100119G1, Amino terminal enhancer of split gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100119G2, Amino terminal enhancer of split gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100119G3, Amino terminal enhancer of split gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001130, NM_198969, NM_198970, N23852
Synonyms	AES-1; AES-2; ESP1; GRG; Grg-5; GRG5; TLE5
Summary	The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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