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Prothrombin (F2) (NM_000506) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC208589L2V
- LentiORF®
-
Lenti ORF particles, F2 (mGFP-tagged) - Human coagulation factor II (thrombin) (F2), 200ul, >10^7 TU/mL
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CNY 9,975.00
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CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Product Name | Prothrombin (F2) (NM_000506) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | PT; RPRGL2; THPH1 |
| Vector | pLenti-C-mGFP |
| ACCN | NM_000506 |
| ORF Size | 1866 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC208589).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_000506.2 |
| RefSeq Size | 2018 bp |
| RefSeq ORF | 1869 bp |
| Locus ID | 2147 |
| Domains | KR, GLA, Tryp_SPc |
| Protein Families | Druggable Genome, Protease, Secreted Protein |
| Protein Pathways | Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Regulation of actin cytoskeleton |
| MW | 70 kDa |
| Gene Summary | This gene encodes the prothrombin protein (also known as coagulation factor II). This protein is proteolytically cleaved in multiple steps to form the activated serine protease thrombin. The activated thrombin enzyme plays an important role in thrombosis and hemostasis by converting fibrinogen to fibrin during blood clot formation, by stimulating platelet aggregation, and by activating additional coagulation factors. Thrombin also plays a role in cell proliferation, tissue repair, and angiogenesis as well as maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in this gene lead to various forms of thrombosis and dysprothrombinemia. Rapid increases in cytokine levels following coronavirus infections can dysregulate the coagulation cascade and produce thrombosis, compromised blood supply, and organ failure. [provided by RefSeq, May 2020] |
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