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Rb2 p130 (RBL2) (NM_005611) Human Untagged Clone
CAT＃: SC317004
RBL2 (untagged)-Human retinoblastoma-like 2 (p130) (RBL2)
CNY 7,936.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | P130; Rb2 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_005611 edited
TTCGCCGTTTGAATGGCTGCGGGCCCGGGCCCTCACCTCACCTGAGGTCCGGCCGCCCAG GGGTGCGCTATGCCGTCGGGAGGTGACCAGTCGCCACCGCCCCCGCCTCCCCCTCCGGCG GCGGCAGCCTCGGATGAGGAGGAGGAGGACGACGGCGAGGCGGAAGACGCCGCGCCGCCT GCCGAGTCGCCCACCCCTCAGATCCAGCAGCGGTTCGACGAGCTGTGCAGCCGCCTCAAC ATGGACGAGGCGGCGCGGGCCGAGGCCTGGGACAGCTACCGCAGCATGAGCGAAAGCTAC ACGCTGGAGGGAAATGATCTTCATTGGTTAGCATGTGCCTTATATGTGGCTTGCAGAAAA TCTGTTCCAACTGTAAGCAAAGGGACAGTGGAAGGAAACTATGTATCTTTAACTAGAATC CTGAAATGTTCAGAGCAGAGCTTAATCGAATTTTTTAATAAGATGAAGAAGTGGGAAGAC ATGGCAAATCTACCCCCACATTTCAGAGAACGTACTGAGAGATTAGAAAGAAACTTCACT GTTTCTGCTGTAATTTTTAAGAAATATGAACCCATTTTTCAGGACATCTTTAAATACCCT CAAGAGGAGCAACCTCGTCAGCAGCGAGGAAGGAAACAGCGGCGACAGCCCTGTACTGTG TCTGAAATTTTCCATTTTTGTTGGGTGCTTTTTATATATGCAAAAGGTAATTTCCCCATG ATTAGTGATGATTTGGTCAATTCTTATCACCTGCTGCTGTGTGCTTTGGACTTAGTTTAT GGAAATGCACTTCAGTGTTCTAATCGTAAAGAACTTGTGAACCCTAATTTTAAAGGCTTA TCTGAAGATTTTCATGCTAAAGATTCTAAACCTTCCTCTGACCCCCCTTGTATCATTGAG AAACTGTGTTCCTTACATGATGGCCTAGTTTTGGAAGCAAAGGGGATAAAGGAACATTTC TGGAAACCCTATATTAGGAAACTTTATGAAAAAAAGCTCCTTAAGGGAAAAGAAGAAAAT CTCACTGGGTTTCTAGAACCTGGGAACTTTGGAGAGAGTTTTAAAGCCATCAATAAGGCC TATGAGGAGTATGTTTTATCTGTTGGGAATTTAGATGAGCGGATATTTCTTGGAGAGGAT GCTGAGGAGGAAATTGGGACTCTCTCAAGGTGTCTGAACGCTGGTTCAGGAACAGAGACT GCTGAAAGGGTGCAGATGAAAAACATCTTACAGCAGCATTTTGACAAGTCCAAAGCACTT AGAATCTCCACACCACTAACTGGTGTTAGGTACATTAAGGAGAATAGCCCTTGTGTGACT CCAGTTTCTACAGCTACGCATAGCTTGAGTCGTCTTCACACCATGCTGACAGGCCTCAGG AATGCACCAAGTGAGAAACTGGAACAGATTCTCAGGACATGTTCCAGAGATCCAACCCAG GCTATTGCTAACAGACTGAAAGAAATGTTTGAAATATATTCTCAGCATTTCCAGCCAGAC GAGGATTTCAGTAATTGTGCTAAAGAAATTGCCAGCAAACATTTTCGTTTTGCGGAGATG CTTTACTATAAAGTATTAGAATCTGTTATTGAGCAGGAACAAAAAAGACTAGGAGACATG GATTTATCTGGTATTCTGGAACAAGATGCGTTCCACAGATCTCTCTTGGCCTGCTGCCTT GAGGTCGTCACTTTTTCTTATAAGCCTCCTGGGAATTTTCCATTTATTACTGAAATATTT GATGTGCCTCTTTATCATTTTTATAAGGTGATAGAAGTATTCATTAGAGCAGAAGATGGC CTTTGTAGAGAGGTGGTAAAACACCTTAATCAGATTGAAGAACAGATCTTAGATCATTTG GCATGGAAACCAGAGTCTCCACTCTGGGAAAAAATTAGAGACAATGAAAACAGAGTTCCT ACATGTGAAGAGAACCTGGAAAGGGCAGATGAAATTTGCATTGCTGGCTCCCCTTTGACT CCCAGAAGGGTGACTGAAGTTCGTGCTGATACTGGAGGACTTGGAAGGAGCATAACATCT CCAACCACATTATACGATAGGTACAGCTCCCCACCAGCCAGCACTACCAGAAGGCGGCTA TTTGTTGAGAATGATAGCCCCTCTGATGGAGGGACGCCTGGGCGCATGCCCCCACAGCCC CTAGTCAATGCTGTCCCTGTGCAGAATGTATCTGGGGAGACTGTTTCTGTCACACCAGTT CCTGGACAGACTTTGGTCACCATGGCAACCGCCACTGTCACAGCCAACAATGGGCAAACG GTAACCATTCCTGTGCAAGGTATTGCCAATGAAAATGGAGGGATAACATTCTTCCCTGTC CAAGTCAATGTTGGGGGGCAGGCACAAGCTGTGACAGGCTCCATCCAGCCCCTCAGTGCT CAGGCCCTGGCTGGAAGTCTGAGCTCTCAACAGGTGACAGGAACAACTTTGCAAGTCCCT GGTCAAGTGGCCATTCAACAGATTTCCCCAGGTGGCCAACAGCAGAAGCAAGGCCAGTCT GTAACCAGCAGTAGTAATAGACCCAGGAAGACCAGCTCTTTATCGCTTTTCTTTAGAAAG GTATACCATTTAGCAGCTGTCCGCCTTCGGGATCTCTGTGCCAAACTAGATATTTCAGAT GAATTGAGGAAAAAAATCTGGACCTGCTTTGAATTCTCCATAATTCAGTGTCCTGAACTT ATGATGGACAGACATCTGGACCAGTTATTAATGTGTGCCATTTATGTGATGGCAAAGGTC ACAAAAGAAGATAAGTCCTTCCAGAACATTATGCGTTGTTATAGGACTCAGCCGCAGGCC CGGAGCCAGGTGTATAGAAGTGTTTTGATAAAAGGGAAAAGAAAAAGAAGAAATTCTGGC AGCAGTGATAGCAGAAGCCATCAGAATTCTCCAACAGAACTAAACAAAGATAGAACCAGT AGAGACTCCAGTCCAGTTATGAGGTCAAGCAGCACCTTGCCAGTTCCACAGCCCAGCAGT GCTCCTCCCACACCTACTCGCCTCACAGGTGCCAACAGTGACATGGAAGAAGAGGAGAGG GGAGACCTCATTCAGTTCTACAACAACATCTACATCAAACAGATTAAGACATTTGCCATG AAGTACTCACAGGCAAATATGGATGCTCCTCCACTCTCTCCCTATCCATTTGTAAGAACA GGCTCCCCTCGCCGAATACAGTTGTCTCAAAATCATCCTGTCTACATTTCCCCACATAAA AATGAAACAATGCTTTCTCCTCGAGAAAAGATTTTCTATTACTTCAGCAACAGTCCTTCA AAGAGACTGAGAGAAATTAATAGTATGATACGCACAGGAGAAACTCCTACTAAAAAGAGA GGAATTCTTTTGGAAGATGGAAGTGAATCACCTGCAAAAAGAATTTGCCCAGAAAATCAT TCTGCCTTATTACGCCGTCTCCAAGATGTAGCTAATGACCGTGGTTCCCACTGAGGTTAG TCTCTTGTATTAAACTCTTCACAAAATCTGTTTAGCAGCAGCCTTTAATGCATCTAGATT ATGGAGCTTTTTTCCTTAATCCAGCTGATGAGTTACAGCCTGTTAGTAACATGAGGGGAC ATTTTGGTGAGAAATGGGACTTAACTCCTTCCAGTGTCCTTAGAACATTTTAATTCATCC CAACTGTCTTTTTTTCCCTACCATTCAGTGATTACTGTCAAGGCTGCTTACAATCCAAAC TTGGATTTTTGACTCTGGCAAAGCTTTTAGAAATACTGCAAGAAAATGATGTGTACCCAA ACGTGAGCATAGGAGGCTTCTGTTGACGTACTCCAACAGAAGAACTGTGTTTCAAGTTCA ATCCTACCTGTTTTGTGGTCAGCTGTAGTCCTCATAAAAAGCAAAACAAAAATTAGGTAT TTTGTCCTAAAACACCTGGTAGGAGTGTGTGATTTTTTGCATTCCTGACAAAGGAGAGCA CACCCAGGTTTGGAGGTCCTAGGTCATTAGCCCTCGTCTCCCGTTCCCTTTGTGCACATC TTCCCTCTCCCCATTCGGTGTGGTGCAGTGTGAAAAGTCCTTGATTGTTCGGGTGTGCAA TGTCTGAGTGAACCTGTATAAGTGGAGGCACTTTAGGGCTGTAAAATGCATGATTTTGTA ACCCAGATTTTGCTGTATATTTGTGATAGCACTTTCTACAATGTGAACTTTATTAAATAC AAAACTTCCAGGCTAAACATCCAATATTTTCTTTAATGCTTTTATATTTTTTTAAAATGT TAAAACCCCTATAGCCACCTTTTGGGAATGTTTTAAATTCTCCAGTTTTTTGTTATATAG GGATCAACCAGCTAAGAAAAGATTTTAATCAAGTTGAATTGAGGGGATTAATATGAAAAC TTATGACCTCTTCCTTTAGGAGGGAGTTATCTAAAAGAAATGTCTATTAAGGTGATATAT TTAAAAATATTTTTGGGTGTTCCTGGCAGTTTAAAAAAATTGGTTGGAGAATTTAGGTTT TTATTAGTACCATAGTACCATTTATACAAATTAGAAAATGTTATTTAACAGCTGAATTAT CTATACATATCTTTATTAATCACTATTGTTCCAGCAGTTTTCAAGTCAAATTAATAATCT TATTAGGGAGAAAATTCAATTGTAAATTGAATCAGTATAAACAAAGTTACTAGGTAACTT CATATTGCTGAGAGAAATATGGAACTTACATTGTTCAATTAGAATAGTGTTCTGCAAAAA TATTTATAAAACTTCTCAAGATACTGCTACTGTAATTTTATATGAAGATAAGTGTATTTT TCAATAAAGCATTTATAAATTAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | NotI-NotI |
| ACCN | NM_005611 |
| Insert Size | 4800 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | The open reading frame of this TrueClone was fully sequenced and found to be a good match to the protein associated to this reference except for a 12bp deletion. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_005611.2, NP_005602.2 |
| RefSeq Size | 4853 bp |
| RefSeq ORF | 3420 bp |
| Locus ID | 5934 |
| UniProt ID | Q08999 |
| Domains | RB_B, RB_A, CYCLIN |
| Protein Families | Druggable Genome, Transcription Factors |
| Protein Pathways | Cell cycle, TGF-beta signaling pathway |
| Gene Summary | Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.[UniProtKB/Swiss-Prot Function] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Peroxisome Proliferator-Activated Receptor ß/ Cross Talks with E2F and Attenuates Mitosis in HRAS-Expressing Cells
,Bokai Zhu, Combiz Khozoie, Moses T. Bility, Christina H. Ferry, Nicholas Blazanin, Adam B. Glick, Frank J. Gonzalez, and Jeffrey M. Peters,
Mol. Cell. Biol., Jun 2012; 32: 2065 - 2082.
[RBL2]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC205380 | RBL2 (Myc-DDK-tagged)-Human retinoblastoma-like 2 (p130) (RBL2) |
CNY 7,600.00 |
|
| RC205380L1 | Lenti ORF clone of Human retinoblastoma-like 2 (p130) (RBL2), Myc-DDK-tagged |
CNY 10,328.00 |
|
| RC205380L2 | Lenti ORF clone of Human retinoblastoma-like 2 (p130) (RBL2), mGFP tagged |
CNY 11,690.00 |
|
| RC205380L3 | Lenti ORF clone of Human retinoblastoma-like 2 (p130) (RBL2), Myc-DDK-tagged |
CNY 11,690.00 |
|
| RC205380L4 | Lenti ORF clone of Human retinoblastoma-like 2 (p130) (RBL2), mGFP tagged |
CNY 11,690.00 |
|
| RG205380 | RBL2 (tGFP-tagged) - Human retinoblastoma-like 2 (p130) (RBL2) |
CNY 9,528.00 |
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