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PAPP A (PAPPA) (NM_002581) Human Untagged Clone
CAT＃: SC309898
PAPPA (untagged)-Human pregnancy-associated plasma protein A, pappalysin 1 (PAPPA)
CNY 16,704.00
| Cited in 2 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | ASBABP2; DIPLA1; IGFBP-4ase; PAPA; PAPP-A; PAPPA1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_002581 edited
AACCGTCGGACATGCGGCTCTGGAGTTGGGTGCTGCACCTGGGGCTGCTGAGCGCCGCGC TGGGCTGCGGGCTGGCCGAGCGTCCCCGCCGGGCCCGGAGAGACCCGCGGGCCGGCCGAC CCCCGCGCCCCGCCGCCGGCCCGGCCACCTGCGCCACCCGGGCGGCCCGCGGCCGCCGCG CCTCGCCGCCGCCGCCGCCGCCGCCGGGCGGTGCCTGGGAAGCCGTGCGCGTCCCCCGGC GGCGGCAGCAGCGGGAGGCGAGGGGCGCCACCGAGGAGCCGAGCCCGCCGAGCCGGGCGC TCTATTTCAGCGGGCGAGGCGAGCAGCTGCGCCTCCGGGCCGACCTCGAGCTGCCCCGGG ACGCGTTCACGCTGCAAGTGTGGCTGCGAGCGGAGGGGGGCCAGAGGTCTCCGGCAGTGA TCACAGGGCTGTATGACAAATGTTCTTATATCTCACGTGACCGAGGATGGGTCGTGGGCA TTCACACCATCAGTGACCAAGACAACAAAGACCCACGCTACTTTTTCTCCTTGAAGACAG ACCGAGCCCGGCAAGTGACCACCATCAATGCCCACCGCAGCTACCTCCCAGGCCAGTGGG TATACCTAGCTGCCACCTATGATGGGCAGTTCATGAAGCTCTATGTGAATGGTGCCCAGG TGGCCACCTCTGGGGAACAAGTGGGTGGCATATTCAGCCCACTGACCCAGAAGTGCAAAG TGCTCATGTTAGGGGGCAGTGCCCTGAATCACAACTACCGGGGCTACATCGAGCACTTCA GTCTGTGGAAGGTGGCCAGGACTCAGCGGGAGATACTGTCTGACATGGAAACCCATGGCG CCCACACTGCTCTACCTCAGCTCCTCCTCCAGGAGAACTGGGACAATGTGAAGCATGCCT GGTCCCCCATGAAGGATGGCAGCAGCCCCAAAGTGGAATTCAGCAATGCCCACGGCTTTC TGCTGGACACGAGTCTGGAGCCTCCTCTGTGTGGACAGACATTGTGTGACAACACAGAGG TCATTGCCAGCTACAATCAGCTCTCAAGTTTCCGCCAGCCCAAGGTGGTGCGCTACCGCG TGGTCAACCTCTATGAAGATGATCATAAGAACCCGACGGTGACGCGCGAGCAGGTGGACT TCCAGCACCATCAGCTGGCTGAGGCCTTCAAGCAATACAACATCTCCTGGGAGCTGGACG TGCTGGAGGTGAGCAACTCCTCTCTTCGCCGCCGCCTCATCCTGGCCAACTGTGACATCA GCAAGATTGGGGATGAGAACTGTGACCCCGAGTGCAACCACACGCTGACGGGCCACGACG GCGGGGATTGCCGCCACCTGCGCCACCCTGCCTTCGTGAAGAAGCAGCACAACGGGGTGT GTGACATGGACTGCAACTATGAACGGTTCAACTTTGATGGTGGAGAGTGCTGTGACCCTG AAATCACCAATGTCACTCAGACTTGCTTTGACCCCGACTCTCCACACAGAGCCTACTTGG ATGTTAATGAGCTGAAGAACATTCTTAAATTGGATGGATCAACACATCTCAATATTTTCT TTGCAAAATCCTCAGAGGAGGAGTTGGCAGGAGTAGCAACTTGGCCATGGGACAAGGAGG CCCTGATGCACTTAGGTGGCATTGTCTTGAACCCATCTTTCTATGGCATGCCTGGGCACA CCCACACCATGATCCATGAGATTGGTCACAGCCTGGGCCTCTATCACGTCTTCCGAGGCA TCTCAGAAATCCAGTCCTGCAGTGACCCCTGCATGGAGACAGAGCCCTCCTTCGAGACTG GAGACCTCTGCAATGATACCAACCCAGCCCCTAAACACAAGTCCTGTGGTGACCCAGGGC CAGGAAATGACACCTGTGGCTTTCATAGCTTCTTCAACACTCCTTACAACAACTTCATGA GCTATGCAGATGACGACTGTACGGACTCCTTCACGCCCAATCAAGTCGCCAGAATGCACT GTTACCTGGACCTGGTCTACCAGGGCTGGCAGCCCTCCAGGAAACCAGCGCCTGTTGCCC TCGCCCCCCAAGTTCTGGGCCACACAACGGACTCTGTGACACTGGAGTGGTTCCCACCTA TAGATGGCCATTTCTTTGAAAGAGAATTGGGATCAGCATGTCATCTTTGCCTGGAAGGGA GAATCCTGGTGCAGTATGCTTCCAACGCTTCCTCCCCAATGCCCTGCAGCCCATCAGGAC ACTGGAGCCCTCGTGAAGCAGAAGGTCATCCTGATGTTGAACAGCCCTGTAAGTCCAGTG TCCGCACCTGGAGCCCAAATTCAGCTGTCAACCCACACACGGTTCCTCCAGCCTGCCCTG AGCCTCAAGGCTGCTACCTCGAGCTGGAGTTCCTCTACCCCTTGGTCCCTGAGTCTCTGA CCATTTGGGTGACCTTTGTCTCCACTGACTGGGACTCTAGTGGAGCTGTCAATGACATCA AACTGTTGGCTGTCAGTGGGAAGAACATCTCCCTGGGTCCTCAGAATGTCTTCTGTGATG TCCCACTGACCATCAGACTCTGGGACGTGGGCGAGGAGGTGTATGGCATCCAAATCTACA CGCTGGATGAGCACCTGGAGATCGATGCTGCCATGTTGACCTCCACTGCAGACACCCCAC TCTGTCTACAGTGTAAGCCCCTGAAGTATAAGGTGGTCCGGGACCCTCCTCTCCAGATGG ATGTGGCCTCCATCCTACATCTCAATAGGAAATTCGTAGACATGGATCTAAATCTTGGCA GTGTGTACCAGTATTGGGTCATAACTATTTCAGGAACTGAAGAGAGTGAGCCATCACCTG CTGTCACATACATCCATGGAAGTGGGTACTGTGGCGATGGCATTATACAAAAAGACCAAG GTGAACAATGCGACGACATGAATAAGATCAATGGTGATGGCTGCTCCCTTTTCTGCCGAC AAGAAGTCTCCTTCAATTGTATTGATGAACCCAGCCGGTGCTATTTCCATGATGGTGATG GGGTATGTGAGGAGTTTGAACAAAAAACCAGCATTAAGGACTGTGGTGTCTACACGCCCC AGGGATTCCTGGATCAGTGGGCATCCAATGCTTCAGTATCTCATCAAGACCAGCAATGCC CAGGCTGGGTCATCATCGGACAGCCAGCAGCATCCCAGGTGTGTCGAACCAAGGTGATAG ATCTCAGTGAAGGCATTTCCCAGCATGCCTGGTACCCTTGCACCATCAGCTACCCATATT CCCAGCTGGCTCAGACCACTTTTTGGCTCCGGGCGTATTTTTCTCAACCAATGGTTGCCG CAGCTGTCATTGTCCACCTGGTGACGGATGGGACATATTATGGGGACCAAAAGCAGGAGA CCATCAGCGTGCAGCTGCTTGATACCAAAGATCAGAGCCACGATCTAGGCCTCCATGTCC TGAGCTGCAGGAACAATCCCCTGATTATCCCTGTGGTCCATGACCTCAGCCAGCCCTTCT ACCACAGCCAGGCGGTACGTGTGAGCTTCAGTTCGCCCCTGGTCGCCATCTCGGGGGTGG CCCTCCGTTCCTTCGACAACTTTGACCCCGTCACCCTGAGCAGCTGCCAGAGAGGGGAGA CCTACAGCCCTGCCGAGCAGAGCTGCGTGCACTTCGCATGTGAGAAAACTGACTGTCCAG AGCTGGCTGTGGAGAATGCTTATCTCAATTGCTCCAGCAGCGACCGCTACCACGGTGCCC AGTGTACTGTGAGCTGCCGGACAGGCTACGTGCTCCAGATACGGCGGGATGATGAGCTGA TCAAGAGCCAGACGGGACCCAGCGTCACAGTGACCTGTACAGAGGGCAAGTGGAATAAGC AGGTGGCCTGTGAGCCAGTCGACTGCAGCATCCCAGATCACCATCAAGTCTATGCTGCCT CCTTCTCCTGCCCTGAGGGCACCACCTTTGGCAGTCAATGTTCCTTCCAGTGCCGTCACC CTGCACAATTGAAAGGCAACAACAGCCTCCTGACCTGCATGGAGGATGGGCTGTGGTCCT TCCCAGAGGCCCTGTGTGAGCTCATGTGCCTCGCTCCACCCCCTGTGCCCAATGCAGACC TCCAGACCGCCCGGTGCCGAGAGAATAAGCACAAGGTGGGCTCCTTCTGCAAATACAAAT GCAAGCCTGGATACCATGTGCCTGGATCCTCTCGGAAGTCAAAGAAACGGGCCTTCAAGA CTCAGTGTACCCAGGATGGCAGCTGGCAGGAGGGAGCTTGTGTTCCTGTGACCTGTGACC CACCTCCACCAAAATTCCATGGGCTCTACCAGTGTACTAATGGCTTCCAGTTCAACAGTG AGTGTAGGATCAAGTGTGAAGACAGTGATGCCTCCCAGGGACTTGGGAGCAATGTCATTC ATTGCCGGAAAGATGGCACCTGGAACGGCTCCTTCCATGTCTGCCAGGAGATGCAAGGCC AGTGCTCGGTTCCAAACGAGCTCAACAGCAACCTCAAACTGCAGTGCCCTGATGGCTATG CCATAGGGTCGGAGTGTGCCACCTCGTGCCTGGACCACAACAGCGAGTCCATCATCCTGC CAATGAACGTGACCGTGCGTGACATCCCCCACTGGCTGAACCCCACACGGGTAGAGAGAG TTGTCTGCACTGCTGGTCTCAAGTGGTATCCTCACCCTGCTCTGATTCACTGTGTCAAAG GCTGTGAGCCCTTCATGGGAGACAATTATTGTGATGCCATCAACAACCGAGCCTTTTGCA ACTATGACGGTGGGGATTGCTGCACCTCCACAGTGAAGACCAAAAAGGTCACCCCATTCC CTATGTCCTGTGACCTACAAGGTGACTGTGCTTGTCGGGACCCCCAGGCCCAAGAACACA GCCGGAAAGACCTCCAGGGATACAGCCATGGCTAAGGAAGGACAAGAAGTTGTCAAAGAA TTCCCAACGCCAGGACCCACATCCCTTTGGTATTGATTTCACAGTCAGCTGCTCAACGGA ATGGCCTCTCCACACCAGGGATCCTTAGCACCCAACCGGTCTGCCCTTAATTTTACCCAG GAAGGACTCACATTGGGGCGAATGAACCAAGTTTCGCCATGCTGGATGATGAAATGGATT CCCATCCCAAAGTCTGAGATGGATTGCATATACAGTGTGCAGTCCCAGAGCCTCCTAAAA TTCTAGCCATTTGTCACACAACCACAGCAAGAAACGTGTTCTATATCTAGAGTGTGCCCA TCTGTGTTTAGTACACATGCATGCATACACACCCATACAAACATCTGTGTGAGGGCAGTT CTGGAGATGAGCAGAGAGAGACCGGAATAAACTCAATCTTTTCTTTCCCAAGCTCCTAGC CAACACTATCCTTGGGAGAAAGGAATTTGCAGAAACTGCTAAGACCAAGTGTGGAGATGT CAAGCTAGTTCACACTCTGAGGCTCAGAATATGTAGGACATGCACAATTGTGCAGTCCTT TGGGATTGGAAGTGAAACAGTCTGTGATCCCCTACCTTCTAGGGAACTAGGACCTAGGAA GAGGTAAAGATTATCAGGTATGCAAAGCGCCCCAATTCTTCTGCTGCCATGGGGGATTTT ACCCCAACTCCAGGGTTCGAGGCCAATCTGAGAATGGCTTAGGATTGCAATGTCAAGGTA TTATATCAGCCCCTTGCTTGAGGCTTGAGGTCATAATATCCCTCTAGGACTTACCTGTTC CCCCAGATCTTGCCTTGGGACCACATTTGCTGCTACTTTTCCTGCTGCTCTATCCTATAC ATTGAATAATCCAAGATGGTAGAACTAGGTTAGGAAAAATTCCACACAACCAAACAGTCT GCCTTAAAAGTGACCCACATTTTTCCATAGCTCCTCACTTTTTAGCCCTTCTGCAAGAGA AAAACCCTCATGGGTCCACATGGTGAGAAGTTAAGTTTCCTGTAAGTGGGCCTCTCACCC TGGAAAGGAGTTGAGGGACATCAGATGCTGGAACCCTCACTGAAAGTCCAGAATGTCTAA GCCAGTGTTAGATTTTGTAAACAAGTGGAACAGTGTTAAATTTCTATGATGTTGGAGCCA TCCAGAGACTACTGGAATTGTCGAGACTTTTGGATTATTATCCTTATCCTTATCCTAATC TTCCTAGCCCTTCAGGCTAGAGTAGGCTTCGATCCTGAGAACCTTGCTGTTGCTCTGAGG AGATATAATTCTGGGAGAAAGAATCTTTTATAAGAACAGTACAGATTGTTCTCAAGAGGG CCATCAGAAGGAAGCCAAAGAGTTCACAGCCTCAGCACCAACAACTCAACATGGTCATCA TGTTTTCTATATGGTTTTTCCAGCTAGCAGTACTCCCTTCCATACCTGTGACTGGGCAGT GCTTTTCTCTCTCCCATGTCTAGCCTCCAAAAGTTAAGTGAAAATTAGTCAACTGCACGT GGAAGCCCCCACCACTTTGGGGATCTCTTTATTTCTTTTCAGCCAGGGACCTGTCCACTC CCTTTGAATTAATATGGGAAGAAATTAATACAGGATGAACTGGAGAGAAGGGTTGAGTGT GGCATACTTTCTGAAACCTGGAGCTGGGAATTGCGGAGAAGGGAAGGTCTAGACTAGTTA CATCACATAGGGATTACTGTAAATCAAGTCATCTCAAGTCTAGTGAAGACAGCCAACAGA AACAAAACCTAGCATAGGGATAGAAAATACCATGCACGTGTGCAGCCCCACCTAATTCCT GCATCCAAGGCAGGTGTTGTTAATCTATCATAGCACCAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_002581 |
| Insert Size | 6800 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | The ORF of this clone has been fully sequenced and found to contain 2 SNPs compared with NM_002581.3. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_002581.3, NP_002572.2 |
| RefSeq Size | 11025 bp |
| RefSeq ORF | 4884 bp |
| Locus ID | 5069 |
| UniProt ID | Q13219 |
| Protein Families | Druggable Genome, Protease, Secreted Protein |
| Gene Summary | This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
MiR-490-3p modulates the proliferation of vascular smooth muscle cells induced by ox-LDL through targeting PAPP-A
,Yufa Sun, Deyou Chen, Lijuan Cao, Rongrong Zhang, Jie Zhou, Haiyan Chen, Yinyin Li, Minglong Li, Jian Cao, and Zhe Wang,
Cardiovasc Res, Jul 2013; 10.1093/cvr/cvt172.
,PubMed ID 23821525
[PAPPA]
|
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MiR-490-3p modulates proliferation of vascular smooth muscle cells induced by ox-LDL through targeting PAPP-A
,Sun, Y;Chen, D;Cao, L;Zhang, R;Zhou, J;Chen, H;,
Cardiovascular Research Advance Access
[PAPPA]
|
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209767 | PAPPA (Myc-DDK-tagged)-Human pregnancy-associated plasma protein A, pappalysin 1 (PAPPA) |
CNY 16,696.00 |
|
| RC209767L1 | Lenti-ORF clone of PAPPA (Myc-DDK-tagged)-Human pregnancy-associated plasma protein A, pappalysin 1 (PAPPA) |
CNY 19,096.00 |
|
| RC209767L2 | Lenti-ORF clone of PAPPA (mGFP-tagged)-Human pregnancy-associated plasma protein A, pappalysin 1 (PAPPA) |
CNY 19,096.00 |
|
| RC209767L3 | Lenti-ORF clone of PAPPA (Myc-DDK-tagged)-Human pregnancy-associated plasma protein A, pappalysin 1 (PAPPA) |
CNY 13,970.00 |
|
| RC209767L4 | Lenti-ORF clone of PAPPA (mGFP-tagged)-Human pregnancy-associated plasma protein A, pappalysin 1 (PAPPA) |
CNY 19,096.00 |
|
| RG209767 | PAPPA (tGFP-tagged) - Human pregnancy-associated plasma protein A, pappalysin 1 (PAPPA) |
CNY 18,296.00 |
