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ORC1 (NM_004153) Human Untagged Clone
CAT＃: SC126369
ORC1 (untagged)-Human origin recognition complex, subunit 1 (ORC1), transcript variant 1
CNY 2,950.00
| Cited in 1 publication. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HSORC1; ORC1L; PARC1 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_004153 edited
CTTTGGTCCTGGCTTTCGGCCCGTAGTTGTAGAAGGAGCCCTGCTGGTGCAGGTTAGAGG TGCCGCATCCCCCGGAGCTCTCGAAGTGGAGGCGGTAGGAAACGGAGGGCTTGCGGCTAG CCGGAGGAAGCTTTGGAGCCGGCCATGGCACACTACCCCACAAGGCTGACTACCAGAAAA ACTTATTCATGGGTTGGCAGGCCCTTGTTGGATCGAAAACTGCACTACCAAACCTATAGA GAAATGTGTGTGAAAACAGAAGGTTGTTCCACCGAGATTCACATCCAGATTGGACAGTTT GTGTTGATTGAAGGGGATGATGATGAAAACCCGTATGTTGCTAAATTGCTTGAGTTGTTC GAAGATGACTCTGATCCTCCTCCTAAGAAACGTGCTCGAGTACAGTGGTTTGTCCGATTC TGTGAAGTCCCTGCCTGTAAACGGCATTTGTTGGGCCGGAAGCCTGGTGCACAGGAAATA TTCTGGTATGATTACCCGGCCTGTGACAGCAACATTAATGCGGAGACCATCATTGGCCTT GTTCGGGTGATACCTTTAGCCCCAAAGGATGTGGTACCGACGAATCTGAAAAATGAGAAG ACACTCTTTGTGAAACTATCCTGGAATGAGAAGAAATTCAGGCCACTTTCCTCAGAACTA TTTGCGGAGTTGAATAAACCACAAGAGAGTGCAGCCAAGTGCCAGAAACCCGTGAGAGCC AAGAGTAAGAGTGCAGAGAGCCCTTCTTGGACCCCAGCAGAACATGTGGCCAAAAGGATT GAATCAAGGCACTCCGCCTCCAAATCTCGCCAAACTCCTACCCATCCTCTTACCCCAAGA GCCAGAAAGAGGCTGGAGCTTGGCAACTTAGGTAACCCTCAGATGTCCCAGCAGACTTCA TGTGCCTCCTTGGATTCTCCAGGAAGAATAAAACGGAAAGTGGCCTTCTCGGAGATCACC TCACCTTCTAAGAGATCTCAGCCTGATAAACTTCAAACCTTGTCTCCAGCTCTGAAAGCC CCAGAGAAAACCAGAGAGACTGGACTCTCTTATACTGAGGATGACAAGAAGGCTTCACCT GAACATCGCATAATCCTGAGAACCCGAATTGCAGCTTCGAAAACCATAGACATTAGAGAG GAGAGAACACTTACCCCTATCAGTGGGGGACAGAGATCTTCAGTGGTGCCATCCGTGATT CTGAAACCAGAAAACATCAAAAAGAGGGATGCAAAAGAAGCAAAAGCCCAGAATGAAGCG ACCTCTACTCCCCATCGTATCCGCAGAAAGAGTTCTGTCTTGACTATGAATCGGATTAGG CAGCAGCTTCGGTTTCTAGGTAATAGTAAAAGTGACCAAGAAGAGAAAGAGATTCTGCCA GCAGCAGAGATTTCAGACTCTAGCAGTGACGAAGAAGAGGCTTCCACACCGCCCCTTCCA AGGAGAGCACCCAGAACTGTGTCCAGGAACCTGCGATCTTCCTTGAAGTCATCCTTACAT ACCCTCACGAAGGTGCCAAAGAAGAGTCTCAAGCCTAGAACGCCACGTTGTGCCGCTCCT CAGATCCGTAGTCGAAGCCTGGCTGCCCAGGAGCCAGCCAGTGTGCTGGAGGAAGCCCGA CTGAGGCTGCATGTTTCTGCTGTACCTGAGTCTCTTCCCTGTCGGGAACAGGAATTCCAA GACATCTACAATTTTGTGGAAAGCAAACTCCTTGACCATACCGGAGGGTGCATGTACATC TCCGGTGTCCCTGGGACAGGGAAGACTGCCACTGTTCATGAAGTGATACGCTGCCTGCAG CAGGCAGCCCAAGCCAATGATGTTCCTCCCTTTCAATACATTGAGGTCAATGGCATGAAG CTGACGGAGCCCCACCAAGTCTATGTGCAAATCTTGCAGAAGCTAACAGGCCAAAAAGCA ACAGCCAACCATGCGGCAGAACTGCTGGCAAAGCAATTCTGCACCCGAGGGTCACCTCAG GAAACCACCGTCCTGCTTGTGGATGAGCTCGACCTTCTGTGGACTCACAAACAAGACATA ATGTACAATCTCTTTGACTGGCCCACTCATAAGGAGGCCCGGCTTGTGGTCCTGGCAATT GCCAACACAATGGACCTGCCAGAGCGAATCATGATGAACCGGGTGTCCAGCCGACTGGGT CTTACCAGGATGTGCTTCCAGCCCTATACATATAGCCAGCTGCAGCAGATCCTAAGGTCC CGGCTCAAGCATCTAAAGGCCTTTGAAGATGATGCCATCCAGCTGGTAGCCAGGAAGGTA GCAGCACTGTCTGGAGATGCACGACGGTGCCTGGACATCTGCAGGCGTGCCACAGAGATC TGTGAGTTCTCCCAGCAGAAGCCTGACTCCCCTGGCCTGGTCACCATAGCCCACTCAATG GAAGCTGTGGATGAGATGTTTTCATCATCATACATCACGGCCATCAAAAATTCCTCTGTT CTGGAACAGAGCTTCCTGAGAGCCATCCTCGCAGAGTTCCGTCGATCAGGACTGGAGGAA GCCACGTTTCAACAGATATATAGTCAACATGTGGCACTGTGCAGAATGGAGGGACTGCCG TACCCCACCATGTCAGAGACCATGGCCGTGTGTTCTCACCTGGGCTCCTGTCGCCTCCTG CTTGTGGAGCCCAGCAGGAACGATCTGCTCCTTCGGGTGCGGCTCAACGTCAGCCAGGAT GATGTGCTGTATGCGCTGAAAGACGAGTAAAGGGGCTTCACAAGTTAAAAGACTGGGGTC TTGCTGGGTTTTGTTTTTTGAGACGGGGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTG GCACGATCATGGCTCACTGCAGCCTTGACTTCTCAGGCTTAGGTGACCCCCCAACCTCAT CCTCCCGGGTGGCTGAAACTACAGGCACATGCCACCATGCCCAGCTGATTTTTTGTAGAG ACAGGGCTTCACCATGTTGCCAAGCTAGTCTACAAAGCATCTGATTTTGGAAGTACATGG AATTGTTGTAACAAAGTATATTGAATGGAAATGGCTCTCATGTATTTTGGAATTTTCCAT TAAATAATTTGCTTTTTCCTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAA >OriGene 5' read for NM_004153 unedited
GTTTTTATTTTGTATACCACTCATATAGGCGGCCGCGTATTCACATGCTGGTACCGGCTC CGGTAATTCCCGGGATATCGTCGACCCACGCGTCCGCTTTGGTCCTGGCTTTCGGCCCGT AGTTGTAGAAGGAGCCCTGCTGGTGCAGGTTAGAGGTGCCGCATCCCCCGGAGCTCTCGA AGTGGAGGCGGTAGGAAACGGAGGGCTTGCGGCTAGCCGGAGGAAGCTTTGGAGCCGGCC ATGGCACACTACCCCACAAGGCTGAAGACCAGAAAAACTTATTCATGGGTTGGCAGGCCC TTGTTGGATCGAAAACTGCACTACCAAACCTATAGAGAAATGTGTGTGAAAACAGAAGGT TGTTCCACCGAGATTCACATCCAGATTGGACAGTTTGTGTTGATTGAAGGGGATGATGAT GAAAACCCGTATGTTGCTAAATTGCTTGAGTTGTTCGAAGATGACTCTGATCCTCCTCCT AAGACACGTGCTCGAGTACAGTGGTTTGTCCGATTCTGTGAAGTCCCTGCCTGTAAACGG CATTTGTTGGGCCGGAAGCCTGGTGCACAGGAAATATTCTGGTATGATTACCCGGCCTGT GACAGCCACATTAATGCGGAGACCATCATTGGCCTTGTTCGGGTGATACCTTTAGCCCCA AAGGATGTGGTACCGACGAATCTGAAAATGAGAAGACACTCTTTGTGAAACTATCCTGGA ATGAGAAGAATTCAGGCCCCTTTTCTCAGAACTATTTTGCGGGTTGAATAAACCACAAGA GAGTGCAGCCCAGTGCCAAAAACCCTGAGAGCCAGGATTAAAGTGCAAAGAGCCTTCTTG GACCCCCCAAAACTGGTGCCCAAGGATGGATCAAGGCACTCCGCTTCAAATTTGGCCAAA TTCTACCCATCCTTTACCCAAGA |
| Restriction Sites | Please inquire |
| ACCN | NM_004153 |
| Insert Size | 3100 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_004153.2, NP_004144.2 |
| RefSeq Size | 3180 bp |
| RefSeq ORF | 2586 bp |
| Locus ID | 4998 |
| UniProt ID | Q13415 |
| Protein Families | Stem cell - Pluripotency |
| Protein Pathways | Cell cycle |
| Gene Summary | The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010] Transcript Variant: This variant (1) is the longest transcript and encodes the longer isoform (1). |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
SCFFbxw15 Mediates Histone Acetyltransferase Binding to Origin Recognition Complex (HBO1) Ubiquitin-Proteasomal Degradation to Regulate Cell Proliferation
,Chunbin Zou, Yan Chen, Rebecca M. Smith, Courtney Snavely, Jin Li, Tiffany A. Coon, Bill B. Chen, Yutong Zhao, and Rama K. Mallampalli,
J. Biol. Chem., Mar 2013; 288: 6306 - 6316.
[ORC1]
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC202058 | ORC1 (Myc-DDK-tagged)-Human origin recognition complex, subunit 1 (ORC1), transcript variant 1 |
CNY 6,304.00 |
|
| RC202058L3 | Lenti ORF clone of Human origin recognition complex, subunit 1 (ORC1), transcript variant 1, Myc-DDK-tagged |
CNY 9,030.00 |
|
| RC202058L4 | Lenti ORF clone of Human origin recognition complex, subunit 1 (ORC1), transcript variant 1, mGFP tagged |
CNY 9,030.00 |
|
| RG202058 | ORC1 (tGFP-tagged) - Human origin recognition complex, subunit 1 (ORC1), transcript variant 1 |
CNY 7,890.00 |
