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Qrich1 (NM_175143) Mouse Untagged Clone
CAT＃: MC221500
Qrich1 (untagged) - Mouse glutamine-rich 1 (Qrich1), transcript variant 2, (10ug)
CNY 9,980.00
Product images
Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Synonyms | 2610028H07Rik; b2b2404Clo |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC221500 representing NM_175143
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGAATAATTCTCTAGAGAACACCATCTCATTTGAAGAGTACATCCGAGTAAAGGCGAGGTCTGTCCCGC AACACAGGATGAAGGAATTTCTGGACTCACTGGCTTCTAAGGGACCAGAAGCTCTTCAGGAGTTCCAGCA GACTGCCACCACCACCATGGTGTACCAGCAGGGTGGGAACTGCATTTATACAGACAGCACTGAAGTGGCT GGGTCTTTGCTTGAACTTGCTTGTCCAGTCACAACCAGTGTTCAACCACAAACTCAGCAAGAGCAGCAGA TCCAGGTTCAGCAGCCACAGCAGGTTCAGGTACAGGTGCAGGTGCAGCAGTCTCCACAACAGGTCTCAGC TCAGCAACTTTCCCCACAGTTCACCGTTCACCAGCCTGCTGAGCAACCCATCCAGGTCCAGGTGCAGATC CAGGGCCAAGCACCACAGTCCGCAGCCCCCTCCATTCAGACTCCATCTCTGCAGAGCCCCAGCCCCTCAC AGCTGCAAGCAGCTCAGATCCAGGTGCAGCACGTCCAGGCGGCCCAACAGATCCAGGCTGCAGAAATCCC AGAGGAGCATATCCCACATCAACAAATCCAGGCTCAGTTGGTAGCTGGCCAATCTCTTGCTGGGGGCCAG CAAATTCAAATTCAGACTGTGGGTGCTCTTTCCCCACCACCATCCCAGCAGGGCTCACCCAGGGAAGGGG AACGGAGGGTTGGCACAGCCAGTGTCCTTCAGCCAGTGAAGAAACGCAAAGTGGACATGCCTATCACCGT GTCCTACGCCATCTCAGGGCAGCCAGTGGCCACTGTGCTGGCCATTCCACAAGGCCAGCAACAGAGTTAT GTGTCTTTGAGGCCAGACTTACTGACAGTAGACAGTGCCCACCTGTACAGTGCCACTGGGACCATAACTA GCCCTACAGGAGAAACTTGGACCATCCCTGTTTATTCTGCCCAGCCCCGCGGGGATCCTCAGCAGCAGAG CATTACGCACATTGCCATTCCCCAGGAAGCCTACAATGCGGTTCATGTCAGTGGCTCACCTACGGCCCTG GCAGCTGTAAAGCTGGAGGATGACAAGGAGAAGATGGTGGGCACCACATCTGTAGTGAAAAACTCCCATG AAGAGGTAGTGCAGACCCTTGCAAACTCTCTCTTTCCAGCACAGTTCATGAATGGCAACATCCACATTCC AGTGGCTGTGCAGGCTGTAGCAGGCACATACCAGAATACGGCTCAGACTGTACATATATGGGACCCACAG CAGCAGCCACAACAGCAAACTGCACAAGAGCAGACACCACCACCACAACAGCAGCAGCAGCAGCTGCAGG TCACTTGTTCAGCACAGACTGTTCAGGTTGCTGAAGTTGAGCCACAGTCACAACCACAGCCTTCACCAGA GCTTTTGCTTCCAAATTCTTTGAAGCCAGAAGAAGGGCTTGAAGTATGGAAAAACTGGGCTCAGACCAAG AATGCTGAACTAGAAAAGGATGCTCAAAACAGATTGGCCCCCATTGGGAGGCGACAGTTGCTACGATTTC AGGAAGATCTGATCTCCTCTGCTGTGGCTGAATTGAATTATGGCCTTTGTTTAATGACACGAGAAGCTCG GAATGGAGAAGGTGAACCCTATGACCCAGATGTACTCTACTACATTTTCCTGTGTATACAGAAGTATCTT TTTGAAAATGGAAGAGTAGATGACATATTTTCTGATCTTTACTATGTTCGTTTCACCGAATGGCTACATG AAGTTCTGAAGGATGTACAGCCTCGGGTCACTCCACTTGGCTATGTGTTGCCCAGTCACGTGACTGAAGA GATGCTGTGGGAATGTAAGCAGCTTGGGGCACATTCCCCTTCCACACTGCTGACCACCCTCATGTTCTTT AACACCAAGTACTTCCTGTTGAAGACTGTAGATCAGCACATGAAGCTGGCTTTCTCTAAGGTCCTCCGAC AGACAAAGAAGAGCCCCTCGAATCCTAAGGATAAAAGCACGAGCATCCGCTACCTGAAGGCCCTCGGAAT ACACCAGACTGGCCAGAAAGTTACAGATGACATGTATGCAGAGCAAACAGAGAATCCAGAGAATCCACTA AGGTGTCCCATCAAGCTCTACGATTTCTACCTCTTTAAATGCCCTCAGAGTGTGAAAGGCCGAAATGACA CCTTTTACCTGACACCTGAGCCAGTTGTAGCTCCCAACAGCCCAATCTGGTACTCAGTCCAGCCTATCAG CAGAGAACAGATGGGACAGATGCTGACCCGGATCCTGGTTATACGAGAAATCCAAGAAGCCATTGCCGTG GCCAATGCAACCACCATGCACTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_175143 |
| Insert Size | 2334 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_175143.5, NP_780352.2 |
| RefSeq Size | 3238 bp |
| RefSeq ORF | 2334 bp |
| Locus ID | 69232 |
| UniProt ID | Q3UA37 |
| Gene Summary | Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352). Controls the outcome of the unfolded protein response (UPR), an ER-stress response pathway that either promotes recovery of ER homeostasis and cell survival, or triggers the terminal UPR which elicits programmed cell death when ER stress is prolonged and unresolved (PubMed:33384352). ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (By similarity). May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (By similarity). Upregulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (PubMed:33384352). Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant lacks an exon in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein. |
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| MG216623 | Qrich1 (tGFP-tagged) - Mouse glutamine-rich 1 (Qrich1) transcript variant 2, (10ug) |
CNY 8,550.00 |
|
| MR216623 | Qrich1 (Myc-DDK-tagged) - Mouse glutamine-rich 1 (Qrich1), transcript variant 2 |
CNY 5,688.00 |
|
| MR216623L3 | Lenti ORF clone of Qrich1 (Myc-DDK-tagged) - Mouse glutamine-rich 1 (Qrich1), transcript variant 2 |
CNY 9,690.00 |
|
| MR216623L4 | Lenti ORF clone of Qrich1 (mGFP-tagged) - Mouse glutamine-rich 1 (Qrich1), transcript variant 2 |
CNY 9,690.00 |
