HIF1AN (NM_017902) Human 3' UTR Clone

Specifications

Product Data
Product Name	HIF1AN (NM_017902) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	FIH1
ACCN	NM_017902
Insert Size	2000 bp
Sequence Data	Insert Sequence (showhide) >SC222457 3’UTR clone of NM_017902 The sequence shown below is from the reference sequence of NM_017902. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC AACACAATGATCAAGGGCCGATACAACTAGCCTGCCAGGGGTCAAGGCCTCCTGCCAGGTGACTGCTAT CCCGTCCACACCGCTTCATTGATGAGGACAGGAGACTCCAAGCGCTAGTATTGCACGCTGCACTTAATG GACTGGACTCTTGCCATGGCCCAGGAGTCAGGTGTTTGGAGCGAGGCAGGGCAGTTGGCACTCCACTCC TATTTGGAGGGACTTCATACCCTTGCCTCTTGTGCCCCAGCACCTTCTCTCTCTGCCCCCCGCCTAAAG TCCTGCATTCAGTGTGTGGAGTCCCAGCTTTTGGTTGTCATCATGTCTGTGTGTATGTTAGTCTGTCAA CTTCGGAATGTGTGCGTGTGTGTGCATGCACACGCATGTATGTATCTGTTCCCTGTTCCTTCTGGGTCA GGCTGTCACTTCCGGCTCTCAGCCCTATCTCCTGCAACCTCAGTGCCTCAGCCTGAGAGAGAGATGAGA TGCTCTTGGACTCCCCACTGCATCTGGGCTGCAGGGCCAGAGCTAGTCTGACCATTAGGTCAGTCTGCC TCCTGACAGTTTTTGCGTAGTCAAGCTCTAGGCGGTATGGGAATGGCTACCGGGACTCTAATGGGGTGA AAGAGAGGGGAGGCTTGCCTTTGAGAGCCTATATAGCCTTCCTGTGAGAGAGGATTAGATAGGGTTCCA ACTGGGCCTACAAGCTCAAGCCATACATAAAAGGACCTTGGGACATAAGAACCAATGATTGTGCATAAG TTCTAAATTAGAGACACATATAGTTTCTCTCTTTCAGCACCAGCTCTTGCCCCTATGCTGGGTACCAAG GGAGTTCTCCTAGCTGTGGCTTCTCTAGGTTCTAGGGGTGCAAGCCTCTGTGTGTTTGTTTGTGTGTGT CTGTGTGTGCGTATCCACACTAGGGGTGCAAGCCTCTGGGTGTGTGTGTGTGTGTGCGTGCGTGTGTGT GTGTGTGTCCGTGTGTGTGTGTGTGTGTGTCCACACTGGCCAGCCTCCCTACTTACCAAGGTTCTCCAC TGCTTACCTTTTCCAGTGGGACAGTACAGTGTGAGCCCCCGGGAAGTACTGCCTGACCTATCCTAAGCT TTTACACTTGGATTTTAGCCATCATATGTTGGCCAGGTCTCACTGCAGCCTGCCCGAGGCTAACTGGCT AGAGCCTCCAGGCCCTATGATGCTCCCTGCCCAGGCCATATCCTTTATTCCTGCTGAGCTTCCTGGCTG AATAGATGAAATGGGGTCAAGCCCAGGCAGCTCATTCACTACCTGTGATCCACCTCAGGGCACGGGCAA ACACATAGGCTTGCGTCTTAAAGCCAGCTCCTCTGCCAGACCCCGTTGTAATGTGCCACAACACCCTCA ATAGTCAGGGCAACTGGTGGAGCATGGAAGTCGAATTTCCTTTTCTGTTAGGAGCTACTCCTGGGAACC CCTCTCAGGGCTGCAGCTTACAGGTGGGCAGCTGTGATTGCACAACTTGAAGGGCCATCATTCACATCT ATTCAGTGGGAGTGGGGTCCCTGGGATTGGGCAGTGTGGTGGCCCTGTGTCTCCTCACCTCTGCTCCTG TCTTCATCACCTTCTCTCTGGAAGGGAAGAGGAGTTGGAAGGTCTCTGGTTTTCTTTTCTTTTTTTTTT TTTTTGCCAAAGGTTTACTTCCAGCATCTGAGCTCTGGCTCTCACCCCTGAAGCTCAGTTATAGTGCAC TGATGAACTGAGAGGATGCGTGTGGATGTGTGTGCATGCCTGAGTGCGTTTTTTGGGGAGGGGTGTTTA TTTTTAGTACCCCATTCTGGGGTTCTCTGATGCAGTGTGGATGTGAAGATATGGTACCTTCTCAAGTGT AGCTCTTTCAAATATAGTCAATGCTGGGAAATGTGATTGCAGTGATCTCTATCTCTCCACTTCTTTTGG GAAAGAGGAGCACAGGAGCGGAGGAAAAACTTGGCCACAGTCACACTTGGAAAGATAGTAGATTATTT ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_017902.3
Synonyms	FIH1
Summary	Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.[UniProtKB/Swiss-Prot Function]
Locus ID	55662
MW	73.1

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