TIAM1 (NM_003253) Human 3' UTR Clone

Specifications

Product Data
Product Name	TIAM1 (NM_003253) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	TIAM-1
ACCN	NM_003253
Insert Size	1980 bp
Sequence Data	Insert Sequence (showhide) >SC217254 3’UTR clone of NM_003253 The sequence shown below is from the reference sequence of NM_003253. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CCCTCCAGGAAACTGAACACTGAGATCTGACTGCGTCACCTGCCCCGTAGAGAATGTGTGTAGATACTT CCTGCCCTAACTCTGCCCACCCTCCTGTACCGTCGACAAGAATGTCCCCTTAGGTCGCGCTCTTGCACA CACGGTTTTGGCAGCTGACTTGGTTCTGAAGCCATGTAGCCACCCAACTTTGTCATTTTCAACAACATC AGAAAGAATTGATCAGAATCCCAAATAAGCTTGAGTCCTATCTTCTGTATATTACTAAGGGCTTTTATT TATTCTCAATAAATCAGGGCCTGAACAATTAAAAGAAAAAAGATTCTATAGCACTGGAAAGCAAATCAC CCCAGGAGTTAACGGATGTACAACAGATTAATTTAAGGGATAGTAGCACACACACGATCCTTCTATCTG AAATCAGTCTCCTAGCTGGGGAAACCTCTTTCACACACAAAATGAAATGTGTACAGCTTGCCGTGTTCT GACTGTACCCTTCCCTCTTCCATGTCTGAGAATCTCCGTGTATTTTAAGAATGTGTGAGGAGAGGGTGG CGATTCATGTTTCAATGAGCCTCTTTTTTTTTTTCCTTCCTGTTTTGGTCTATGGCTGGTCTTACTCTG TGTCCATGTTCGGAAGCTCTAGTTTTGCATAGAATTATAGAGATGCCAAACTCTTTGAAAAGAGATCCA AATTTATCGCTTGAGAGAAAGAAAAGAAACACTATTTTTTGTATTTTACCTGAGATACAGGGGCACAAA TAGATGAGAATTTTACAGTGTTAGTGTATGTATCCCTGAGCCTAAAAAATGAGGATATAACCTTTTACA GAGAGAGTGAGGCGTGGTGGTTTTATATTTATATATGAAAGGCCAGCAAGCTCATGCGAAGGATATACT TTTCTTCCAAAAAGCGGATTTTTTTTTTTTAATGTTTGAATCTATATTTGAGATGGGAGTTTGGTTGGA TTAAACATGACACCCCGGTGGGCGGTGTGTGTGTCTGTTGCACATGGCAGGGAGGGGAGCCTCCTTCTC ATGGGGTTGCCATGGTGATCATTGGTTTTTCCATCAAAATTGCATCTTCATCCATAGATTACCTTCCCC TTCCCTGACAGTCCATAACCAAACCTTTAAACAGAACAACCTCTTTAAAAACTTCTCTTGTGTTTAACA CTTTCTTCATGCCAACGAAACAGGGTAAACATGCTCAAAACATTAACAGTCTAAACAGATATCCAAATA CTAAGAAGAAAAACAAGTTATAGCACTTTCAATTTTTTTTTTTTTTTTAAAAAAAGGTTTATAGCTTTT TCTTTTCCCATGTCACAATGTCCACTTCCTAAGAAGGGTTTAAAATACTATGAAAACTTTCTTTTTGGG GAAAATATCTATTTGGTGTTTGACACATCAGTAGGTACTTTAAAGACCTGAATTTTATAGTAGCTTTAG GAGTTATATTTTATAAAAATCAGTTATGACTTTATATTTCCAGACAATAGAGAGTTCAGTACATCATGC TCTTGTGCCTCTGCCTGCTTTTCCTGCGTTCCCACCCTGTATTCCCCCCGCCTTTCGGGTTTCCAGGGC TTCGAGCTTGATCTTTTGAAAGTTTTATTCTATTAAATTTTTGCTATATCTTCTGGTTTTCTGAAAAAG CTTTAGAATGGTTTCTATACCCTTTGTATCACTGCATTTTTCCATATCATCTCCGGTTCGATCGCGTCC AGATGGAAAACGGAAGCAGAGGCTTCTAATCGTCGCATTTACTGGCTCCAGTGCAACACATCCATCTGA AAACACTCGGAAGTCTGGTGCTTGGAGAGGGTGCCATTGTCTCTTGTACATAAGGTCATGACGTGTCTA TGTCAAAAGTTCTTATATATTTCTTTTATAAGCTGAAAGAAGGTCTATTTTTATGTTTTTAGGTCTATG AATGGAACGTTGTAAATGCTTGTCAAACAATAAAAATAACGAAAAGTG ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_003253.3
Synonyms	TIAM-1
Summary	This gene encodes a RAC1-specific guanine nucleotide exchange factor (GEF). GEFs mediate the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP). The binding of GTP induces a conformational change in RAC1 that allows downstream effectors to bind and transduce a signal. This gene thus regulates RAC1 signaling pathways that affect cell shape, migration, adhesion, growth, survival, and polarity, as well as influencing actin cytoskeletal formation, endocytosis, and membrane trafficking. This gene thus plays an important role in cell invasion, metastasis, and carcinogenesis. In addition to RAC1, the encoded protein activates additional Rho-like GTPases such as CDC42, RAC2, RAC3 and RHOA. This gene encodes multiple protein isoforms that experience a diverse array of intramolecular, protein-protein, and phosphorylation interactions as well as phosphoinositide binding. Both the longer and shorter isoforms have C-terminal Dbl homology (DH) and pleckstrin homology (PH) domains while only the longer isoforms of this gene have the N-terminal myristoylation site and the downstream N-terminal PH domain, ras-binding domain (RBD), and PSD-95/DlgA/ZO-1 (PDZ) domain. [provided by RefSeq, Jul 2017]
Locus ID	7074
MW	76.7

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