ADAM17 (NM_003183) Human 3' UTR Clone

Specifications

Product Data
Product Name	ADAM17 (NM_003183) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE
ACCN	NM_003183
Insert Size	1721 bp
Sequence Data	Insert Sequence (showhide) >SC211049 3’UTR clone of NM_003183 The sequence shown below is from the reference sequence of NM_003183. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CGTGTTGACAGCAAAGAAACAGAGTGCTAATTTAGTTCTCAGCTCTTCTGACTTAAGTGTGCAAAATAT TTTTATAGATTTGACCTACAAATCAATCACAGCTTGTATTTTGTGAAGACTGGGAAGTGACTTAGCAGA TGCTGGTCATGTGTTTGAACTTCCTGCAGGTAAACAGTTCTTGTGTGGTTTGGCCCTTCTCCTTTTGAA AAGGTAAGGTGAAGGTGAATCTAGCTTATTTTGAGGCTTTCAGGTTTTAGTTTTTAAAATATCTTTTGA CCTGTGGTGCAAAAGCAGAAAATACAGCTGGATTGGGTTATGAATATTTACGTTTTTGTAAATTAATCT TTTATATTGATAACAGCACTGACTAGGGAAATGATCAGTTTTTTTTTATACACTGTAATGAACCGCTGA ATATGAGGCATTTGGCATTTATTTGTGATGACAACTGGAATAGTTTTTTTTTTTTTTTTTTTTTTTTGC CTTCAACTAAAAACAAAGGAGATAAATCTAGTATACATTGTCTCTAAATTGTGGGTCTATTTCTAGTTA TTACCCAGAGTTTTTATGTAGCAGGGAAAATATATATCTAAATTTAGAAATCATTTGGGTTAATATGGC TCTTCATAATTCTAAGACTAATGCTCTCTAGAAACCTAACCACCTACCTTACAGTGAGGGCTATACATG GTAGCCAGTTGAATTTATGGAATCTACCAACTGTTTAGGGCCCTGATTTGCTGGGCAGTTTTTCTGTAT TTTATAAGTATCTTCATGTATCCCTGTTACTGATAGGGATACATGCTCTTAGAAAATTCACTATTGGCT GGGAGTGGTGGCTCATGCCTGTAATCCCAGCACTTGGAGAGGCTGAGGTTGCGCCACTACACTCCAGCC TGGGTGACAGAGTGAGACTCTGCCTCAAAAAAAAAAAAAAAAAAAAAAAATTCACTATCTACAAACCTA GAATATTTAAAATACAAAGATTGCCTGTTTTCAAACACTATTGAATAAGAGGGTGAGATATTTCTTAAC AACAACAACAACAAAAAAAACAGGTTGTTTTGAATGTGATGAGCCAGCCAGGAGATAGAATACTACCTG CCCTTAGGGTTGGGGGCTGTCCCCACAAGACTTGATACTTCAGAAACCCTTTTTATTGACCCACAAGCA GATATTTGAATTACTTCTTACTTTATTGCTCCAGGATTCTGGATGGGCTGCATTTACTGTGTGAAGGAT AAAAATCATTAGCCTGGATTCTGATTTCTATAAATTGCCATTAAAAGCTTTTTTTCCCCTAAGAACTGA AATGTGCTCACCAGCCAAAACATTTTAACTTGTAAATTTTGAGGGCAGTTAACCAAACCTGTGACTAAT CATATCTCCTCCTACCCCCCATTTCCAAGGACATTTGTTACTCAGATACTTGTTATACTAATACTTGAA CTTGTACCTTATGGTATTTGCTATCTTTTAACTAGTCATGATATTCTTATACTTTAGTTACACTTTTGG AATTTGATACAAGGTTGAGTGGGGTGTGTGGGTGTATGTATGAGTGAAACAGTTCTCAAAAGAATGTAA GAAAAACCATTTTTATAAAATTGTGACTTTTTAAAAACATAGTCTTTGTCATTTATAGAATTAACAAGC TGCTCAGGGTATATTTTATAGCTGTAGCACTGATATCTGCATTAATAAATACTGTCGAAACACAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_003183.6
Synonyms	ADAM18; CD156B; CSVP; NISBD; NISBD1; TACE
Summary	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands, and plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. Additionally, this protease may play a role in viral infection through its cleavage of ACE2, the cellular receptor for SARS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2020]
Locus ID	6868
MW	66.8

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