PPT1 Mouse Monoclonal Antibody [Clone ID: OTI1F10]

Specifications

Product Data
Clone Name	OTI1F10
Applications	IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:500
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human recombinant protein fragment corresponding to amino acids 100-306 of human PPT1 (NP_000301) produced in E.coli.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	1 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	31.2 kDa
Gene Name	palmitoyl-protein thioesterase 1
Database Link	NP_000301 Entrez Gene 5538 Human UniProt ID P50897
Background	The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Synonyms	CLN1; INCL; PPT
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Fatty acid elongation in mitochondria, Lysosome, Metabolic pathways

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