A2ML1 Rabbit Monoclonal Antibody [Clone ID: OTIR2E11]

Specifications

Product Data
Clone Name	OTIR2E11
Applications	SISCAPA
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human A2ML1 (NP_653271). The exact sequence is proprietary.
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	Lot dependent; please refer to CoA along with shipment
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	161 kDa
Gene Name	alpha-2-macroglobulin like 1
Database Link	NP_653271 Entrez Gene 144568 Human UniProt ID A8K2U0
Background	This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interactions with proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID:20805888). Mutations in these gene have also been associated with some cases of Noonan syndrome (NS; PMID:24939586) as well as some cases of otitis media (PMID:26121085). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Synonyms	CPAMD9; OMS; p170
Reference Data

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