TP63 Mouse Monoclonal Antibody [Clone ID: 14D5E8F12]

Specifications

Product Data
Clone Name	14D5E8F12
Applications	ELISA, IHC
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	The original antibody was generated by immunizing mice with p40 peptide comprising amino acids 4-19 (LENNAQTQFSEPQYTN) of the p63 protein (Uniprot -Q9H3D4). The p40 peptide had a sulfhydryl group at its N-terminus and a carrier protein KLH to improve its immunogenicity.
Specificity	This antibody is specific for the p40 peptide of the human p63. P63 protein acts as a sequence specific DNA binding transcriptional activator or repressor. It is also involved in notch signaling by probably inducing JAG1 and JAG2 and plays a role in the regulation of epithelial morphogenesis. The p63 molecule has a high degree of structural homology with p53 and has three similar functional domains: N-terminal transcription activation region, core DNA binding region, and C-terminal oligomerization region. This antibody is highly similar to commercially available rabbit antibody ZR8 in immunohistochemical staining of p40. This antibody does not stain lung adenocarcinoma but positively stains lung squamous cell carcinoma. This antibody can used for the differential diagnosis of lung squamous cell carcinoma and lung adenocarcinoma via immunohistochemical staining. This binding specificity and affinity of this antibody was determined using ELISA. The original IgG1 antibody is reported to bind human p40 with an affinity constant of 5.99 X 10^9 M^(-1) (CN104447994).
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C.
Database Link	UniProt ID Q9H3D4
Synonyms	chronic ulcerative stomatitis protein; CUSP; Keratinocyte transcription factor KET; p40; p51; p73L; TP63; Transformation-related protein 63; Tumor protein 63; Tumor protein p73-like; ZR8
Reference Data

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