CD10 (MME) Mouse Monoclonal Antibody [Clone ID: 56C6]

Specifications

Product Data
Clone Name	56C6
Applications	IHC
Recommend Dilution	1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant fusion protein corresponding to the external domain of the human CD10 glycoprotein
Specificity	Human CD10 molecule, also known as common acute lymphocytic leukemia antigen (CALLA)
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	membrane metallo-endopeptidase
Database Link	Entrez Gene 4311 Human UniProt ID P08473
Background	CD10 antigen, also called neprilysin, is a 100 kD cell surface metalloendopeptidase which inactivates a variety of biologically active peptides. It was initially identified as the common acute lymphoblastic leukemia antigen (CALLA) and was thought to be tumor-specific. Subsequent studies, however, have shown that CD10 antigen is expressed on the surface of a wide variety of normal and neoplastic cells. In other lymphoid malignancies, CD10 antigen is reported to be expressed on cells of lymphoblastic, Burkitt's and follicular lymphomas. CD10 antigen has been identified on the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue. It is also expressed in various non-lymphoid cells and tissues, such as breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells. (G. McIntosh et al. American Journal of Pathology. 154(1): 77-82 (1999)).
Synonyms	atriopeptidase; CALLA; CD10; DKFZp686O16152; Enkephalinase; EPN; MGC126681; MGC126707; NEP; neprilysin
Reference Data

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