SIGLEC6 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: A549 cell lysate IHC: 50-300 Positive control: Human liver cancer Predicted cell location: Secreted and Cell membrane
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide of human SIGLEC6
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	50 kDa
Gene Name	sialic acid binding Ig like lectin 6
Database Link	NP_942142 Entrez Gene 946 Human UniProt ID O43699
Background	The SIGLEC6 gene to 19q13.3, which is where the CD33 gene is located. Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine.
Synonyms	CD33L; CD33L1; CD33L2; CD327; CDW327; OBBP1
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane

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