AKIP (AURKAIP1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 500-2000 WB positive control: Human testis tissue
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human AURKAIP1
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	22 kDa
Gene Name	aurora kinase A interacting protein 1
Database Link	NP_060370 Entrez Gene 54998 Human UniProt ID Q9NWT8
Background	AKIP (AURKA-interacting protein), also known as AURKAIP1 (aurora kinase A interacting protein 1) or AIP, is a 199 amino acid protein that localizes to the nucleus and is ubiquitously expressed, with highest levels present in testis, heart and skeletal muscle. Interacting specifically with ARK-1 (aurora kinase 1), AKIP functions to induce the proteasomal-dependent degradation of ARK-1, thereby acting as a negative regulator of ARK-1 activity. AKIP is encoded by a gene which maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson?s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
Synonyms	AIP; AKIP; MRP-S38
Reference Data
Protein Families	Druggable Genome

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