ABCG5 Mouse Monoclonal Antibody [Clone ID: 1B5E10]

Specifications

Product Data
Clone Name	1B5E10
Applications	ELISA, FC, IF, IHC, WB
Recommend Dilution	Flow Cytometry: 1:200 - 1:400, ELISA: 1:10000, Immunohistochemistry: 1:200 - 1:2000, Western Blot: 1:500 - 1:2000, Immunohistochemistry-Paraffin: 1:200 - 1:2000, ICC/IF (Negative)
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Partial recombinant human ABCG5 (between residues 300-500) expressed in E. coli [UniProt Q9H222].
Formulation	PBS, 0.03% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Ammonium sulfate precipitation
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	ATP binding cassette subfamily G member 5
Database Link	NP_071881 Entrez Gene 64240 Human UniProt ID Q9H222
Background	ABCG5 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC proteins are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). ABCG5 is a member of the White subfamily. It functions as a half-transporter to limit intestinal absorption and promote biliary excretion of sterols. ABCG5 is expressed in a tissue-specific manner in the liver, colon, and intestine. Mutations in this protein may contribute to sterol accumulation and atheroschlerosis, and they have been observed in patients with sitosterolemia (1).
Synonyms	STSL
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	ABC transporters

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.