ZAP70 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC, WB
Recommend Dilution	WB 1:500-1:2000
Reactivity	Human, Mouse, Rat
Modifications	Phospho-specific
Host	Rabbit
Clonality	Polyclonal
Immunogen	A phospho specific peptide corresponding to residues surrounding Y493 of human ZAP70
Formulation	Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	619
Gene Name	zeta chain of T cell receptor associated protein kinase 70kDa
Database Link	NP_001070 Entrez Gene 22637 MouseEntrez Gene 301348 RatEntrez Gene 7535 Human UniProt ID P43403
Background	This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Synonyms	SRK; STCD; STD; TZK; ZAP-70
Reference Data
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Natural killer cell mediated cytotoxicity, Primary immunodeficiency, T cell receptor signaling pathway

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