GABA B Receptor 2 (GABBR2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1:200-1:2000; IHC: 1:100-1:3000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide CKDPIEDINSPEHIQRRLSL, corresponding to amino acid residues 875-894 of human GABA(B) R2. Intracellular, C-terminus.
Formulation	Lyophilized. Concentration before lyophilization ~0.8mg/ml (lot dependent, please refer to CoA along with shipment for actual concentration). Buffer before lyophilization: phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.
Reconstitution Method	Add 50 ul double distilled water (DDW) to the lyophilized powder.
Purification	Affinity purified on immobilized antigen.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	gamma-aminobutyric acid type B receptor subunit 2
Database Link	NP_005449 Entrez Gene 83633 RatEntrez Gene 242425 MouseEntrez Gene 9568 Human UniProt ID O75899
Background	GABA (gamma-aminobutyric acid) is the major inhibitory neurotransmitter in the central nervous system and plays a crucial role in the modulation of neuronal activity.The GABA transmitter interacts with three types of receptors: the ionotropic receptors, GABA (A) R and GABA (C) R, and the metabotropic GABA (B) receptor, [GABA (B) R].The latter belongs to the G-protein-coupled receptor (GPCR) superfamily and mediates slow synaptic inhibition in the brain and spinal cord.The functional GABA (B) receptor [GABA (B)R] is a heterodimer consisting of two subunits, the GABA (B) R1 and the GABA (B) R2. These subunits were demonstrated to have complementary roles essential for the functional receptor.GABA (B) R2 has been shown to be essential for trafficking and for G-protein binding while the GABA (B) R1 subunit has been demonstrated to be important for agonist and antagonist binding. GABA (B) R2 is highly expressed in brain, especially in the cerebral cortex, thalamus, and hippocampus, spinal cord, and, to a lesser extent, in testis.
Synonyms	GABABR2; GPR51; GPRC3B; HG20; HRIHFB2099
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction

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